EIF5B | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	43 studies	34% ± 14%	Explore
fibroblast	39 studies	29% ± 11%	Explore
pericyte	34 studies	32% ± 11%	Explore
B cell	32 studies	26% ± 7%	Explore
natural killer cell	32 studies	26% ± 6%	Explore
smooth muscle cell	31 studies	30% ± 10%	Explore
CD8-positive, alpha-beta T cell	31 studies	26% ± 8%	Explore
T cell	30 studies	25% ± 7%	Explore
macrophage	30 studies	25% ± 9%	Explore
CD4-positive, alpha-beta T cell	29 studies	25% ± 9%	Explore
conventional dendritic cell	22 studies	27% ± 11%	Explore
endothelial cell of lymphatic vessel	21 studies	32% ± 11%	Explore
basal cell	21 studies	35% ± 15%	Explore
epithelial cell	20 studies	36% ± 18%	Explore
regulatory T cell	20 studies	25% ± 8%	Explore
mast cell	19 studies	23% ± 6%	Explore
plasma cell	19 studies	35% ± 13%	Explore
memory B cell	18 studies	24% ± 8%	Explore
ciliated cell	17 studies	39% ± 16%	Explore
naive B cell	17 studies	24% ± 8%	Explore
gamma-delta T cell	17 studies	30% ± 12%	Explore
mature NK T cell	16 studies	24% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	23% ± 6%	Explore
capillary endothelial cell	14 studies	27% ± 11%	Explore
myofibroblast cell	14 studies	27% ± 10%	Explore
connective tissue cell	14 studies	31% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	27% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	27% ± 8%	Explore
non-classical monocyte	13 studies	24% ± 7%	Explore
endothelial cell of vascular tree	13 studies	31% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	25% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	27% ± 7%	Explore
vein endothelial cell	12 studies	33% ± 10%	Explore
type I pneumocyte	11 studies	29% ± 11%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	23% ± 6%	Explore
secretory cell	11 studies	35% ± 13%	Explore
classical monocyte	11 studies	22% ± 8%	Explore
mucosal invariant T cell	11 studies	24% ± 3%	Explore
plasmacytoid dendritic cell	11 studies	26% ± 10%	Explore
monocyte	10 studies	26% ± 8%	Explore
type II pneumocyte	10 studies	27% ± 14%	Explore
plasmablast	10 studies	44% ± 17%	Explore
club cell	10 studies	26% ± 11%	Explore
oligodendrocyte	10 studies	25% ± 8%	Explore
endothelial cell of artery	10 studies	33% ± 10%	Explore
myeloid cell	10 studies	25% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	30% ± 9%	Explore
progenitor cell	9 studies	24% ± 7%	Explore
abnormal cell	9 studies	33% ± 12%	Explore
astrocyte	9 studies	28% ± 12%	Explore
goblet cell	9 studies	33% ± 15%	Explore
oligodendrocyte precursor cell	9 studies	26% ± 7%	Explore
neuron	8 studies	36% ± 16%	Explore
mesothelial cell	8 studies	27% ± 14%	Explore
dendritic cell	8 studies	34% ± 16%	Explore
alveolar macrophage	7 studies	22% ± 4%	Explore
respiratory goblet cell	7 studies	29% ± 12%	Explore
leukocyte	7 studies	28% ± 9%	Explore
glutamatergic neuron	7 studies	41% ± 17%	Explore
microglial cell	7 studies	27% ± 9%	Explore
adipocyte	7 studies	20% ± 4%	Explore
T follicular helper cell	7 studies	21% ± 3%	Explore
GABAergic neuron	7 studies	32% ± 16%	Explore
hematopoietic precursor cell	6 studies	36% ± 16%	Explore
ionocyte	6 studies	25% ± 8%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	30% ± 6%	Explore
mononuclear phagocyte	6 studies	26% ± 12%	Explore
kidney loop of Henle epithelial cell	6 studies	23% ± 6%	Explore
transit amplifying cell	6 studies	33% ± 15%	Explore
lymphocyte	6 studies	31% ± 14%	Explore
precursor B cell	6 studies	29% ± 8%	Explore
innate lymphoid cell	6 studies	27% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	30% ± 11%	Explore
interneuron	6 studies	32% ± 19%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	26% ± 4%	Explore
enteroendocrine cell	5 studies	34% ± 12%	Explore
IgA plasma cell	5 studies	27% ± 7%	Explore
IgG plasma cell	5 studies	27% ± 3%	Explore
glial cell	5 studies	25% ± 16%	Explore
erythroblast	5 studies	48% ± 24%	Explore
mucus secreting cell	5 studies	26% ± 6%	Explore
cardiac muscle cell	5 studies	23% ± 4%	Explore
deuterosomal cell	4 studies	31% ± 6%	Explore
duct epithelial cell	4 studies	25% ± 4%	Explore
pancreatic A cell	4 studies	49% ± 19%	Explore
type B pancreatic cell	4 studies	47% ± 22%	Explore
exhausted T cell	4 studies	26% ± 10%	Explore
retinal ganglion cell	4 studies	55% ± 28%	Explore
brush cell	4 studies	29% ± 18%	Explore
immature B cell	4 studies	27% ± 7%	Explore
pro-B cell	4 studies	26% ± 10%	Explore
amacrine cell	4 studies	41% ± 18%	Explore
retina horizontal cell	4 studies	35% ± 16%	Explore
retinal rod cell	4 studies	25% ± 9%	Explore
acinar cell	4 studies	41% ± 26%	Explore
erythrocyte	4 studies	39% ± 20%	Explore
muscle cell	4 studies	33% ± 16%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	47% ± 10%	Explore
hepatocyte	4 studies	56% ± 25%	Explore
luminal cell of prostate epithelium	4 studies	37% ± 7%	Explore
hematopoietic stem cell	4 studies	33% ± 15%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	50% ± 11%	Explore
keratinocyte	4 studies	32% ± 12%	Explore
T-helper 17 cell	4 studies	28% ± 5%	Explore
double negative thymocyte	4 studies	35% ± 14%	Explore
hillock cell	3 studies	30% ± 8%	Explore
squamous epithelial cell	3 studies	37% ± 24%	Explore
pancreatic D cell	3 studies	49% ± 24%	Explore
glomerular endothelial cell	3 studies	23% ± 2%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	31% ± 8%	Explore
enterocyte	3 studies	19% ± 2%	Explore
intestinal crypt stem cell	3 studies	28% ± 8%	Explore
neural crest cell	3 studies	35% ± 3%	Explore
retinal bipolar neuron	3 studies	41% ± 14%	Explore
extravillous trophoblast	3 studies	39% ± 6%	Explore
placental villous trophoblast	3 studies	38% ± 6%	Explore
common myeloid progenitor	3 studies	24% ± 9%	Explore
retinal cone cell	3 studies	38% ± 14%	Explore
retinal pigment epithelial cell	3 studies	38% ± 21%	Explore
serous secreting cell	3 studies	34% ± 9%	Explore
Mueller cell	3 studies	28% ± 6%	Explore
ON-bipolar cell	3 studies	25% ± 5%	Explore
rod bipolar cell	3 studies	33% ± 8%	Explore
chondrocyte	3 studies	25% ± 10%	Explore
germinal center B cell	3 studies	28% ± 5%	Explore
CD4-positive helper T cell	3 studies	32% ± 10%	Explore
myoepithelial cell	3 studies	34% ± 9%	Explore
granulocyte	3 studies	22% ± 5%	Explore
pancreatic ductal cell	3 studies	58% ± 17%	Explore
granulocyte monocyte progenitor cell	3 studies	36% ± 5%	Explore
group 3 innate lymphoid cell	3 studies	30% ± 12%	Explore
melanocyte	3 studies	25% ± 2%	Explore
granule cell	3 studies	19% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	23% ± 5%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	26% ± 5%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	27% ± 4%	Explore
progenitor cell of mammary luminal epithelium	3 studies	20% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	19 studies	31% ± 13%	Explore
brain	17 studies	28% ± 12%	Explore
peripheral blood	14 studies	27% ± 8%	Explore
intestine	10 studies	25% ± 11%	Explore
eye	9 studies	26% ± 11%	Explore
kidney	8 studies	24% ± 5%	Explore
liver	8 studies	36% ± 20%	Explore
pancreas	5 studies	43% ± 22%	Explore
bone marrow	5 studies	25% ± 6%	Explore
uterus	5 studies	35% ± 16%	Explore
prostate	5 studies	28% ± 10%	Explore
heart	4 studies	21% ± 4%	Explore
lymph node	4 studies	30% ± 11%	Explore
breast	4 studies	32% ± 11%	Explore
adipose	4 studies	23% ± 6%	Explore
placenta	3 studies	37% ± 5%	Explore
thymus	3 studies	35% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	6562.66	180 / 180	100%	69.76	430 / 430
pancreas	100%	7019.09	328 / 328	100%	45.72	178 / 178
prostate	100%	11861.99	245 / 245	100%	67.30	502 / 502
thymus	100%	8124.81	653 / 653	100%	59.94	605 / 605
uterus	100%	8685.44	170 / 170	100%	64.31	459 / 459
esophagus	100%	12446.88	1444 / 1445	100%	103.03	183 / 183
brain	100%	8826.87	2638 / 2642	100%	71.17	704 / 705
breast	100%	8251.49	459 / 459	100%	92.34	1114 / 1118
liver	100%	5210.40	225 / 226	100%	33.79	405 / 406
lung	99%	8064.35	575 / 578	100%	73.32	1153 / 1155
skin	100%	10812.58	1808 / 1809	99%	74.95	468 / 472
bladder	100%	12340.57	21 / 21	99%	65.58	499 / 504
kidney	100%	7587.34	89 / 89	99%	51.60	892 / 901
stomach	100%	8549.25	359 / 359	99%	72.21	283 / 286
intestine	100%	10987.15	966 / 966	98%	66.51	518 / 527
adrenal gland	100%	7548.10	258 / 258	98%	37.64	226 / 230
adipose	100%	8824.42	1204 / 1204	0%	0	0 / 0
blood vessel	100%	10140.38	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	64.06	29 / 29
muscle	100%	14948.10	803 / 803	0%	0	0 / 0
spleen	100%	7764.72	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	70.38	45 / 45
ureter	0%	0	0 / 0	100%	34.00	1 / 1
heart	99%	12916.75	856 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	94%	30.13	75 / 80
peripheral blood	43%	4645.26	404 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	EIF5B
Protein name	Eukaryotic translation initiation factor 5B (Translation initiation factor IF-2) Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) eIF5B protein
Synonyms	KIAA0741 IF2
Description	FUNCTION: Plays a role in translation initiation . Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon . Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex . Is released after formation of the 80S initiation complex . Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes . In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit . .
Accessions	Q8N5A0 ENST00000617677.1 A0A087WUT6 Q05CQ1 ENST00000289371.11 O60841 A0JLR8

GO_0006446	Biological process	regulation of translational initiation
GO_0006413	Biological process	translational initiation
GO_0042255	Biological process	ribosome assembly
GO_0005829	Cellular component	cytosol
GO_0045202	Cellular component	synapse
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0003743	Molecular function	translation initiation factor activity
GO_0005525	Molecular function	GTP binding
GO_0000049	Molecular function	tRNA binding
GO_0003924	Molecular function	GTPase activity
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding
GO_0003723	Molecular function	RNA binding

EIF5B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review