RPS6KA3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043154Biological processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0002224Biological processtoll-like receptor signaling pathway
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0030307Biological processpositive regulation of cell growth
GO_0007165Biological processsignal transduction
GO_0045597Biological processpositive regulation of cell differentiation
GO_0035556Biological processintracellular signal transduction
GO_0043066Biological processnegative regulation of apoptotic process
GO_0007268Biological processchemical synaptic transmission
GO_0043555Biological processregulation of translation in response to stress
GO_0007417Biological processcentral nervous system development
GO_0001501Biological processskeletal system development
GO_0032496Biological processresponse to lipopolysaccharide
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0005737Cellular componentcytoplasm
GO_0043027Molecular functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO_0106310Molecular functionprotein serine kinase activity
GO_0004711Molecular functionribosomal protein S6 kinase activity
GO_0019901Molecular functionprotein kinase binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0000287Molecular functionmagnesium ion binding
GO_0004672Molecular functionprotein kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRPS6KA3
Protein nameRPS6KA3 protein
Ribosomal protein S6 kinase A3
Ribosomal protein S6 kinase A3 (cDNA FLJ56618, highly similar to Ribosomal protein S6 kinase alpha-3)
Insulin-stimulated protein kinase 1
Ribosomal protein S6 kinase A3 (cDNA, FLJ79381, highly similar to Ribosomal protein S6 kinase alpha-3)
Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2)
SynonymsMAPKAPK1B
ISPK1
RSK2
DescriptionFUNCTION: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 . In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes . In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP . Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity . Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex . In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation . Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway . Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function . Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) . Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (By similarity). In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3 (By similarity). Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1 (By similarity). Phosphorylates SOS1 at 'Ser-1134' and 'Ser-1161' that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation (By similarity). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration . Acts as a regulator of osteoblast differentiation by mediating phosphorylation of ATF4, thereby promoting ATF4 transactivation activity (By similarity). .

AccessionsENST00000457145.6
Q8TDJ4
P51812
ENST00000643337.1
A0A2R8Y7S9
ENST00000647265.1
ENST00000642835.1
ENST00000643073.1
B7ZB17
ENST00000646610.1
ENST00000645270.1
Q7Z2J4
Q7Z2J3
B4DG22
A0A2R8YGB7
ENST00000645268.1
ENST00000644893.1
B1AXG2
ENST00000643402.1
B1AXG1
Q7Z2E2
A0A2R8Y603
ENST00000644368.1
ENST00000438357.2
ENST00000479809.1
ENST00000379565.9
ENST00000643085.1