Name | Number of supported studies | Average coverage | |
---|---|---|---|
natural killer cell | 7 studies | 20% ± 2% | |
endothelial cell | 6 studies | 27% ± 10% | |
epithelial cell | 6 studies | 33% ± 13% | |
CD16-positive, CD56-dim natural killer cell, human | 5 studies | 20% ± 3% | |
CD8-positive, alpha-beta T cell | 5 studies | 19% ± 3% | |
ciliated cell | 5 studies | 28% ± 7% | |
abnormal cell | 5 studies | 21% ± 4% | |
CD16-negative, CD56-bright natural killer cell, human | 4 studies | 19% ± 2% | |
effector memory CD8-positive, alpha-beta T cell | 4 studies | 18% ± 2% | |
fibroblast | 4 studies | 24% ± 7% | |
plasmacytoid dendritic cell | 4 studies | 21% ± 5% | |
gamma-delta T cell | 4 studies | 20% ± 8% | |
B cell | 3 studies | 20% ± 5% | |
CD4-positive, alpha-beta T cell | 3 studies | 18% ± 3% | |
classical monocyte | 3 studies | 24% ± 6% | |
conventional dendritic cell | 3 studies | 27% ± 7% | |
mature NK T cell | 3 studies | 17% ± 1% | |
non-classical monocyte | 3 studies | 29% ± 5% | |
smooth muscle cell | 3 studies | 21% ± 2% | |
basal cell | 3 studies | 33% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
adrenal gland | 100% | 3621.64 | 258 / 258 | 100% | 69.02 | 230 / 230 |
esophagus | 100% | 3026.49 | 1445 / 1445 | 100% | 65.46 | 183 / 183 |
liver | 100% | 1957.23 | 226 / 226 | 100% | 84.53 | 406 / 406 |
ovary | 100% | 2619.92 | 180 / 180 | 100% | 135.46 | 430 / 430 |
pancreas | 100% | 1784.62 | 328 / 328 | 100% | 80.87 | 178 / 178 |
thymus | 100% | 3260.07 | 653 / 653 | 100% | 83.04 | 605 / 605 |
uterus | 100% | 3155.81 | 170 / 170 | 100% | 91.19 | 459 / 459 |
brain | 100% | 2103.05 | 2638 / 2642 | 100% | 67.42 | 705 / 705 |
skin | 100% | 2667.79 | 1809 / 1809 | 100% | 96.52 | 471 / 472 |
kidney | 100% | 3129.76 | 89 / 89 | 100% | 64.66 | 897 / 901 |
stomach | 100% | 2629.96 | 359 / 359 | 99% | 77.61 | 284 / 286 |
intestine | 100% | 3326.25 | 966 / 966 | 99% | 81.65 | 523 / 527 |
prostate | 100% | 3526.82 | 245 / 245 | 99% | 88.30 | 498 / 502 |
breast | 100% | 2951.12 | 459 / 459 | 99% | 94.90 | 1108 / 1118 |
lung | 100% | 2855.56 | 578 / 578 | 99% | 83.30 | 1143 / 1155 |
bladder | 100% | 3166.86 | 21 / 21 | 98% | 91.19 | 494 / 504 |
adipose | 100% | 2965.39 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 146.58 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 79.09 | 29 / 29 |
muscle | 100% | 2818.40 | 803 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 100% | 3363.15 | 929 / 929 | 0% | 0 | 0 / 0 |
spleen | 100% | 3362.84 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 77.61 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 174.25 | 1 / 1 |
blood vessel | 100% | 2929.17 | 1334 / 1335 | 0% | 0 | 0 / 0 |
heart | 100% | 2334.33 | 860 / 861 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0097039 | Biological process | protein linear polyubiquitination |
GO_0031424 | Biological process | keratinization |
GO_0030262 | Biological process | apoptotic nuclear changes |
GO_0010803 | Biological process | regulation of tumor necrosis factor-mediated signaling pathway |
GO_0007005 | Biological process | mitochondrion organization |
GO_0050728 | Biological process | negative regulation of inflammatory response |
GO_0043123 | Biological process | positive regulation of canonical NF-kappaB signal transduction |
GO_0042742 | Biological process | defense response to bacterium |
GO_2000348 | Biological process | regulation of CD40 signaling pathway |
GO_0043161 | Biological process | proteasome-mediated ubiquitin-dependent protein catabolic process |
GO_0071797 | Cellular component | LUBAC complex |
GO_0030425 | Cellular component | dendrite |
GO_0005829 | Cellular component | cytosol |
GO_0045202 | Cellular component | synapse |
GO_0044877 | Molecular function | protein-containing complex binding |
GO_0042802 | Molecular function | identical protein binding |
GO_0030674 | Molecular function | protein-macromolecule adaptor activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0004842 | Molecular function | ubiquitin-protein transferase activity |
GO_0031593 | Molecular function | polyubiquitin modification-dependent protein binding |
GO_0005515 | Molecular function | protein binding |
GO_0043130 | Molecular function | ubiquitin binding |
Gene name | SHARPIN |
Protein name | SHARPIN protein SHANK associated RH domain interactor Sharpin (Shank-associated RH domain-interacting protein) (Shank-interacting protein-like 1) (hSIPL1) |
Synonyms | SIPL1 PSEC0216 |
Description | FUNCTION: Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation . LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways . Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation . LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex . The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria . LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin . The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation . Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis . . |
Accessions | ENST00000359551.6 [Q9H0F6-2] Q6PJD5 H0YCU2 ENST00000398712.7 [Q9H0F6-1] ENST00000532536.5 Q9H0F6 |