LIN7B report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LIN7B at tissue level.

III. Associated gene sets

GO_1903361Biological processprotein localization to basolateral plasma membrane
GO_0015031Biological processprotein transport
GO_0045199Biological processmaintenance of epithelial cell apical/basal polarity
GO_0006887Biological processexocytosis
GO_0007269Biological processneurotransmitter secretion
GO_0005911Cellular componentcell-cell junction
GO_0097025Cellular componentMPP7-DLG1-LIN7 complex
GO_0098839Cellular componentpostsynaptic density membrane
GO_0098793Cellular componentpresynapse
GO_0045202Cellular componentsynapse
GO_0005886Cellular componentplasma membrane
GO_0016323Cellular componentbasolateral plasma membrane
GO_0005923Cellular componentbicellular tight junction
GO_0030165Molecular functionPDZ domain binding
GO_0097016Molecular functionL27 domain binding
GO_0019901Molecular functionprotein kinase binding
GO_0019904Molecular functionprotein domain specific binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLIN7B
Protein nameProtein lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2) (hVeli2)
Lin-7 homolog B, crumbs cell polarity complex component
SynonymsUNQ3116/PRO10200
MALS2
VELI2
DescriptionFUNCTION: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity). .

AccessionsENST00000595200.5
S4R3R4
ENST00000486217.2
M0R2U1
Q9HAP6
ENST00000391864.7 [Q9HAP6-2]
ENST00000221459.7 [Q9HAP6-1]