CACNA1E report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0098703Biological processcalcium ion import across plasma membrane
GO_0007268Biological processchemical synaptic transmission
GO_0005891Cellular componentvoltage-gated calcium channel complex
GO_0045202Cellular componentsynapse
GO_0043025Cellular componentneuronal cell body
GO_0005886Cellular componentplasma membrane
GO_0008331Molecular functionhigh voltage-gated calcium channel activity
GO_0005245Molecular functionvoltage-gated calcium channel activity
GO_0005509Molecular functioncalcium ion binding
GO_0022843Molecular functionvoltage-gated monoatomic cation channel activity

IV. Literature review

[source]
Gene nameCACNA1E
Protein nameVoltage-gated calcium channel alpha 1E subunit
Voltage-dependent calcium channel alpha 1E subunit
Calcium voltage-gated channel subunit alpha1 E
Voltage-dependent R-type calcium channel subunit alpha-1E (Brain calcium channel II) (BII) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Voltage-gated calcium channel subunit alpha Cav2.3)
Voltage-dependent R-type calcium channel subunit alpha
SynonymsCACNL1A6
CACH6
DescriptionFUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells . They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. .

AccessionsQ15878
ENST00000360108.7
Q9NYZ5
ENST00000621791.4 [Q15878-2]
Q9NYZ6
ENST00000644521.1
ENST00000700188.1
ENST00000700190.1
Q9UN68
ENST00000524607.6
F8W9Z1
A0A2R8Y7W1
ENST00000367570.6 [Q15878-3]
A0A8V8TPU6
ENST00000367573.7 [Q15878-1]
A0A8V8TPE9
E9PIE8
Q9NY05