ARFGAP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015031Biological processprotein transport
GO_0016192Biological processvesicle-mediated transport
GO_0032012Biological processregulation of ARF protein signal transduction
GO_0030100Biological processregulation of endocytosis
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0005096Molecular functionGTPase activator activity

IV. Literature review

[source]
Gene nameARFGAP1
Protein nameADP ribosylation factor GTPase activating protein 1
ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein)
SynonymsARF1GAP
DescriptionFUNCTION: GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). .

AccessionsENST00000522403.6
E5RHC5
ENST00000549076.1
ENST00000370283.9 [Q8N6T3-1]
E5RHH7
ENST00000353546.7 [Q8N6T3-2]
ENST00000370275.8 [Q8N6T3-3]
ENST00000523114.5
E5RHT6
F8VWB3
ENST00000518601.6
ENST00000547204.5
ENST00000523460.5
ENST00000519604.5 [Q8N6T3-5]
E5RIU2
ENST00000519273.6 [Q8N6T3-4]
E5RGL6
Q8N6T3
ENST00000520485.5
F8VWH9
ENST00000550188.1
ENST00000549047.5
H0YIQ0
F8W1U7