PSMA3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	40 studies	28% ± 11%	Explore
fibroblast	33 studies	26% ± 12%	Explore
natural killer cell	29 studies	25% ± 9%	Explore
pericyte	26 studies	23% ± 6%	Explore
macrophage	25 studies	24% ± 10%	Explore
CD8-positive, alpha-beta T cell	24 studies	28% ± 13%	Explore
T cell	23 studies	25% ± 8%	Explore
smooth muscle cell	22 studies	24% ± 7%	Explore
CD4-positive, alpha-beta T cell	22 studies	27% ± 16%	Explore
regulatory T cell	19 studies	27% ± 11%	Explore
B cell	18 studies	21% ± 7%	Explore
conventional dendritic cell	18 studies	28% ± 14%	Explore
basal cell	17 studies	31% ± 15%	Explore
plasmacytoid dendritic cell	16 studies	31% ± 11%	Explore
epithelial cell	16 studies	34% ± 21%	Explore
mast cell	14 studies	21% ± 5%	Explore
endothelial cell of lymphatic vessel	14 studies	25% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	22% ± 5%	Explore
ciliated cell	14 studies	34% ± 17%	Explore
connective tissue cell	14 studies	25% ± 7%	Explore
gamma-delta T cell	14 studies	25% ± 14%	Explore
endothelial cell of vascular tree	13 studies	29% ± 9%	Explore
mature NK T cell	12 studies	22% ± 6%	Explore
capillary endothelial cell	12 studies	28% ± 6%	Explore
plasma cell	11 studies	40% ± 12%	Explore
monocyte	11 studies	22% ± 7%	Explore
classical monocyte	11 studies	27% ± 11%	Explore
myofibroblast cell	11 studies	25% ± 6%	Explore
vein endothelial cell	11 studies	26% ± 6%	Explore
type I pneumocyte	10 studies	25% ± 11%	Explore
type II pneumocyte	10 studies	28% ± 14%	Explore
plasmablast	10 studies	45% ± 22%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	23% ± 6%	Explore
non-classical monocyte	10 studies	31% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	25% ± 6%	Explore
endothelial cell of artery	10 studies	26% ± 5%	Explore
mucosal invariant T cell	10 studies	21% ± 3%	Explore
dendritic cell	10 studies	38% ± 24%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	27% ± 9%	Explore
secretory cell	9 studies	31% ± 17%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	20% ± 4%	Explore
myeloid cell	9 studies	28% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	25% ± 9%	Explore
abnormal cell	8 studies	26% ± 8%	Explore
astrocyte	8 studies	27% ± 8%	Explore
memory B cell	8 studies	23% ± 12%	Explore
epithelial cell of proximal tubule	7 studies	26% ± 6%	Explore
progenitor cell	7 studies	24% ± 3%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	28% ± 10%	Explore
alveolar macrophage	6 studies	22% ± 5%	Explore
hematopoietic precursor cell	6 studies	36% ± 23%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	37% ± 17%	Explore
leukocyte	6 studies	25% ± 9%	Explore
innate lymphoid cell	6 studies	22% ± 5%	Explore
club cell	6 studies	31% ± 13%	Explore
neuron	6 studies	29% ± 10%	Explore
T follicular helper cell	6 studies	20% ± 2%	Explore
mononuclear phagocyte	5 studies	26% ± 12%	Explore
kidney loop of Henle epithelial cell	5 studies	23% ± 4%	Explore
enterocyte	5 studies	18% ± 3%	Explore
erythroblast	5 studies	37% ± 14%	Explore
retinal rod cell	5 studies	25% ± 10%	Explore
adipocyte	5 studies	20% ± 6%	Explore
mesothelial cell	5 studies	26% ± 13%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	32% ± 13%	Explore
oligodendrocyte	5 studies	22% ± 3%	Explore
oligodendrocyte precursor cell	5 studies	28% ± 3%	Explore
deuterosomal cell	4 studies	23% ± 1%	Explore
pancreatic A cell	4 studies	45% ± 16%	Explore
naive B cell	4 studies	25% ± 4%	Explore
exhausted T cell	4 studies	33% ± 10%	Explore
lymphocyte	4 studies	30% ± 11%	Explore
precursor B cell	4 studies	30% ± 9%	Explore
pro-B cell	4 studies	26% ± 2%	Explore
adventitial cell	4 studies	25% ± 8%	Explore
cardiac muscle cell	4 studies	18% ± 1%	Explore
Mueller cell	4 studies	20% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	35% ± 7%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	27% ± 9%	Explore
GABAergic neuron	4 studies	39% ± 10%	Explore
glutamatergic neuron	4 studies	47% ± 12%	Explore
microglial cell	4 studies	19% ± 1%	Explore
goblet cell	4 studies	29% ± 9%	Explore
transit amplifying cell	4 studies	23% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	20% ± 5%	Explore
duct epithelial cell	3 studies	19% ± 3%	Explore
ionocyte	3 studies	29% ± 10%	Explore
respiratory goblet cell	3 studies	40% ± 24%	Explore
type B pancreatic cell	3 studies	59% ± 2%	Explore
glomerular endothelial cell	3 studies	26% ± 4%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	33% ± 6%	Explore
neural crest cell	3 studies	28% ± 2%	Explore
extravillous trophoblast	3 studies	37% ± 8%	Explore
placental villous trophoblast	3 studies	72% ± 11%	Explore
common myeloid progenitor	3 studies	30% ± 14%	Explore
neuroendocrine cell	3 studies	36% ± 9%	Explore
immature B cell	3 studies	20% ± 4%	Explore
retinal bipolar neuron	3 studies	27% ± 10%	Explore
serous secreting cell	3 studies	23% ± 4%	Explore
acinar cell	3 studies	37% ± 17%	Explore
germinal center B cell	3 studies	21% ± 4%	Explore
intermediate monocyte	3 studies	34% ± 17%	Explore
muscle cell	3 studies	29% ± 13%	Explore
pancreatic ductal cell	3 studies	55% ± 14%	Explore
granulocyte monocyte progenitor cell	3 studies	44% ± 25%	Explore
hematopoietic stem cell	3 studies	29% ± 11%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	46% ± 18%	Explore
enteroendocrine cell	3 studies	33% ± 12%	Explore
intestinal crypt stem cell	3 studies	27% ± 9%	Explore
glial cell	3 studies	28% ± 17%	Explore
group 3 innate lymphoid cell	3 studies	28% ± 14%	Explore
keratinocyte	3 studies	20% ± 3%	Explore
T-helper 17 cell	3 studies	40% ± 22%	Explore
interneuron	3 studies	38% ± 12%	Explore
T-helper 1 cell	3 studies	34% ± 12%	Explore
double negative thymocyte	3 studies	39% ± 20%	Explore
progenitor cell of mammary luminal epithelium	3 studies	18% ± 2%	Explore
hepatocyte	3 studies	41% ± 18%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	16 studies	29% ± 13%	Explore
peripheral blood	14 studies	25% ± 8%	Explore
kidney	8 studies	24% ± 3%	Explore
intestine	7 studies	24% ± 10%	Explore
eye	7 studies	25% ± 9%	Explore
brain	7 studies	33% ± 12%	Explore
liver	6 studies	29% ± 17%	Explore
bone marrow	5 studies	20% ± 3%	Explore
uterus	5 studies	28% ± 15%	Explore
pancreas	4 studies	46% ± 17%	Explore
lymph node	4 studies	22% ± 8%	Explore
breast	4 studies	24% ± 3%	Explore
placenta	3 studies	46% ± 15%	Explore
heart	3 studies	18% ± 1%	Explore
prostate	3 studies	22% ± 7%	Explore
thymus	3 studies	45% ± 17%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	2633.29	21 / 21	100%	97.09	504 / 504
breast	100%	2930.56	459 / 459	100%	95.06	1118 / 1118
esophagus	100%	2765.10	1445 / 1445	100%	91.74	183 / 183
liver	100%	2881.88	226 / 226	100%	68.56	406 / 406
ovary	100%	1887.86	180 / 180	100%	60.64	430 / 430
stomach	100%	2280.06	359 / 359	100%	80.97	286 / 286
uterus	100%	2422.32	170 / 170	100%	109.48	459 / 459
kidney	100%	2939.28	89 / 89	100%	57.80	900 / 901
thymus	100%	2828.35	653 / 653	100%	83.84	604 / 605
lung	100%	3296.14	577 / 578	100%	97.84	1155 / 1155
intestine	100%	2692.66	966 / 966	100%	92.68	526 / 527
skin	100%	2674.69	1809 / 1809	100%	69.53	470 / 472
prostate	100%	2264.49	244 / 245	100%	74.08	501 / 502
brain	99%	1694.99	2624 / 2642	100%	57.55	705 / 705
adrenal gland	100%	3882.62	258 / 258	99%	67.50	228 / 230
pancreas	99%	1498.58	324 / 328	99%	75.04	177 / 178
adipose	100%	3052.76	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	125.76	29 / 29
muscle	100%	4519.89	803 / 803	0%	0	0 / 0
spleen	100%	3174.49	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	104.02	45 / 45
ureter	0%	0	0 / 0	100%	61.42	1 / 1
blood vessel	100%	2756.43	1333 / 1335	0%	0	0 / 0
heart	98%	2538.48	847 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	94%	47.77	75 / 80
peripheral blood	66%	2174.00	614 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0052548	Biological process	regulation of endopeptidase activity
GO_0043161	Biological process	proteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000502	Cellular component	proteasome complex
GO_0070062	Cellular component	extracellular exosome
GO_0005839	Cellular component	proteasome core complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0045202	Cellular component	synapse
GO_0019773	Cellular component	proteasome core complex, alpha-subunit complex
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PSMA3
Protein name	Proteasome subunit alpha type-3 (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8) Proteasome 20S subunit alpha 3 Proteasome subunit alpha type
Synonyms	PSC8 HC8
Description	FUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2. .
Accessions	ENST00000412908.6 [P25788-2] ENST00000557508.5 ENST00000555931.5 ENST00000553677.1 ENST00000216455.9 [P25788-1] H0YJ03 Q6IB71 ENST00000557087.5 G3V4X5 G3V5N4 G3V3W4 P25788

PSMA3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review