DSCAM | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
oligodendrocyte precursor cell	13 studies	84% ± 24%	Explore
glutamatergic neuron	11 studies	72% ± 26%	Explore
microglial cell	11 studies	54% ± 18%	Explore
GABAergic neuron	9 studies	64% ± 20%	Explore
astrocyte	7 studies	39% ± 19%	Explore
neuron	6 studies	42% ± 22%	Explore
oligodendrocyte	6 studies	37% ± 21%	Explore
endothelial cell	5 studies	50% ± 17%	Explore
interneuron	5 studies	63% ± 29%	Explore
retinal ganglion cell	5 studies	81% ± 31%	Explore
macrophage	3 studies	28% ± 10%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	88% ± 5%	Explore
granule cell	3 studies	68% ± 19%	Explore
GABAergic amacrine cell	3 studies	65% ± 4%	Explore
OFF-bipolar cell	3 studies	67% ± 23%	Explore
glycinergic amacrine cell	3 studies	56% ± 24%	Explore
retina horizontal cell	3 studies	24% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	45% ± 22%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	1379.51	2638 / 2642	98%	29.54	693 / 705
spleen	35%	71.30	84 / 241	0%	0	0 / 0
adrenal gland	0%	0.82	1 / 258	10%	0.44	23 / 230
tonsil	0%	0	0 / 0	9%	0.20	4 / 45
pancreas	1%	0.87	2 / 328	7%	0.51	12 / 178
esophagus	0%	0	0 / 1445	5%	0.14	10 / 183
lung	0%	0	0 / 578	4%	0.13	45 / 1155
bladder	0%	0	0 / 21	4%	0.12	18 / 504
uterus	0%	0	0 / 170	3%	0.15	15 / 459
breast	1%	1.09	3 / 459	2%	0.10	26 / 1118
kidney	0%	0	0 / 89	2%	0.05	19 / 901
ovary	0%	0	0 / 180	2%	0.07	9 / 430
intestine	1%	0.92	5 / 966	1%	0.06	6 / 527
stomach	0%	0.70	1 / 359	1%	0.02	3 / 286
eye	0%	0	0 / 0	1%	0.05	1 / 80
skin	0%	0.49	4 / 1809	1%	0.03	4 / 472
liver	0%	0	0 / 226	1%	0.02	4 / 406
prostate	0%	0	0 / 245	0%	0.04	2 / 502
thymus	0%	0.30	1 / 653	0%	0.00	1 / 605
heart	0%	0.51	2 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
adipose	0%	0	0 / 1204	0%	0	0 / 0
blood vessel	0%	0	0 / 1335	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0042327	Biological process	positive regulation of phosphorylation
GO_0048813	Biological process	dendrite morphogenesis
GO_0007162	Biological process	negative regulation of cell adhesion
GO_0007155	Biological process	cell adhesion
GO_0007156	Biological process	homophilic cell adhesion via plasma membrane adhesion molecules
GO_0060060	Biological process	post-embryonic retina morphogenesis in camera-type eye
GO_0007626	Biological process	locomotory behavior
GO_0007417	Biological process	central nervous system development
GO_0038007	Biological process	netrin-activated signaling pathway
GO_0007416	Biological process	synapse assembly
GO_0060219	Biological process	camera-type eye photoreceptor cell differentiation
GO_0048842	Biological process	positive regulation of axon extension involved in axon guidance
GO_0007399	Biological process	nervous system development
GO_0007411	Biological process	axon guidance
GO_0070593	Biological process	dendrite self-avoidance
GO_0010842	Biological process	retina layer formation
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0043025	Cellular component	neuronal cell body
GO_0030425	Cellular component	dendrite
GO_0045202	Cellular component	synapse
GO_0030426	Cellular component	growth cone
GO_0030424	Cellular component	axon
GO_0098632	Molecular function	cell-cell adhesion mediator activity
GO_1990782	Molecular function	protein tyrosine kinase binding
GO_0005515	Molecular function	protein binding
GO_1990890	Molecular function	netrin receptor binding

IV. Literature review

[source]

Gene name	DSCAM
Protein name	DS cell adhesion molecule DS cell adhesion molecule (Down syndrome cell adhesion molecule splice variant) Cell adhesion molecule DSCAM (CHD2) (Down syndrome cell adhesion molecule)
Synonyms
Description	FUNCTION: Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies . Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. Might also collaborate with UNC5C in NTN1-mediated axon repulsion independently of DCC (By similarity). In spinal cord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding . Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38 . Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity). .
Accessions	A0A087WUI7 ENST00000404019.2 O60469 ENST00000400454.6 [O60469-1] ENST00000617870.4 ENST00000708009.1 [O60469-1] Q8WY19

DSCAM report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review