Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 9 studies | 44% ± 22% | |
| GABAergic neuron | 7 studies | 43% ± 21% | |
| retinal cone cell | 7 studies | 47% ± 19% | |
| retinal rod cell | 7 studies | 21% ± 4% | |
| amacrine cell | 5 studies | 33% ± 10% | |
| neuron | 4 studies | 26% ± 8% | |
| retinal bipolar neuron | 4 studies | 41% ± 10% | |
| interneuron | 4 studies | 47% ± 23% | |
| retinal ganglion cell | 3 studies | 46% ± 16% | |
| macrophage | 3 studies | 24% ± 10% | |
| rod bipolar cell | 3 studies | 30% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 93% | 14467.27 | 2458 / 2642 | 87% | 16.32 | 615 / 705 |
| adrenal gland | 5% | 62.71 | 13 / 258 | 93% | 6.16 | 214 / 230 |
| ovary | 1% | 3.86 | 1 / 180 | 59% | 1.59 | 252 / 430 |
| skin | 0% | 0.69 | 1 / 1809 | 12% | 0.23 | 55 / 472 |
| eye | 0% | 0 | 0 / 0 | 11% | 1.33 | 9 / 80 |
| uterus | 0% | 0 | 0 / 170 | 8% | 0.18 | 38 / 459 |
| pancreas | 0% | 0 | 0 / 328 | 8% | 0.92 | 14 / 178 |
| thymus | 0% | 0 | 0 / 653 | 6% | 0.10 | 35 / 605 |
| breast | 0% | 0 | 0 / 459 | 5% | 0.12 | 57 / 1118 |
| tonsil | 0% | 0 | 0 / 0 | 4% | 0.15 | 2 / 45 |
| esophagus | 0% | 0 | 0 / 1445 | 4% | 0.07 | 8 / 183 |
| lung | 0% | 0 | 0 / 578 | 4% | 0.08 | 48 / 1155 |
| stomach | 0% | 1.98 | 1 / 359 | 3% | 0.09 | 10 / 286 |
| kidney | 0% | 0 | 0 / 89 | 4% | 0.06 | 33 / 901 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.04 | 1 / 29 |
| liver | 0% | 0 | 0 / 226 | 2% | 0.04 | 9 / 406 |
| intestine | 0% | 0 | 0 / 966 | 2% | 0.05 | 10 / 527 |
| bladder | 0% | 0 | 0 / 21 | 2% | 0.04 | 8 / 504 |
| prostate | 0% | 0 | 0 / 245 | 1% | 0.02 | 5 / 502 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| adipose | 0% | 0 | 0 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 0 | 0 / 1335 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| heart | 0% | 0 | 0 / 861 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0055064 | Biological process | chloride ion homeostasis |
| GO_0007612 | Biological process | learning |
| GO_0072488 | Biological process | ammonium transmembrane transport |
| GO_0006811 | Biological process | monoatomic ion transport |
| GO_0035264 | Biological process | multicellular organism growth |
| GO_0006884 | Biological process | cell volume homeostasis |
| GO_0055075 | Biological process | potassium ion homeostasis |
| GO_0051452 | Biological process | intracellular pH reduction |
| GO_0060996 | Biological process | dendritic spine development |
| GO_1902476 | Biological process | chloride transmembrane transport |
| GO_0007268 | Biological process | chemical synaptic transmission |
| GO_0030644 | Biological process | intracellular chloride ion homeostasis |
| GO_0009410 | Biological process | response to xenobiotic stimulus |
| GO_0006971 | Biological process | hypotonic response |
| GO_0040040 | Biological process | thermosensory behavior |
| GO_1990573 | Biological process | potassium ion import across plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0043204 | Cellular component | perikaryon |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0043005 | Cellular component | neuron projection |
| GO_0071944 | Cellular component | cell periphery |
| GO_0045202 | Cellular component | synapse |
| GO_0032590 | Cellular component | dendrite membrane |
| GO_0008519 | Molecular function | ammonium channel activity |
| GO_0015108 | Molecular function | chloride transmembrane transporter activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0015379 | Molecular function | potassium:chloride symporter activity |
| Gene name | SLC12A5 |
| Protein name | KCC2 transcript variant 7 (Solute carrier family 12 member 5) KCC2 transcript variant 9 KCC2 transcript variant 3 (Solute carrier family 12 member 5) HCG1821261 (Solute carrier family 12 member 5) Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (K-Cl cotransporter 2) (hKCC2) (Neuronal K-Cl cotransporter) KCC2 transcript variant 5 KCC2 transcript variant 1 Solute carrier family 12 member 5 KCC2 transcript variant 8 (Solute carrier family 12 member 5) KCC2 transcript variant 4 KCC2 transcript variant 2 KCC2 transcript variant 6 |
| Synonyms | KIAA1176 hCG_1821261 KCC2 |
| Description | FUNCTION: Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis . As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation . . |
| Accessions | ENST00000616202.4 A0A0D9SGF9 M4PNC0 V9GYL3 M4PM71 ENST00000243964.7 [Q9H2X9-2] B7Z3T3 M4PJG5 M4PJL7 ENST00000539566.3 ENST00000454036.6 [Q9H2X9-1] M4PJG0 ENST00000637437.1 M4PNB5 M4PV58 Q9H2X9 A0A0D9SF89 ENST00000626937.2 ENST00000608944.5 ENST00000628272.1 ENST00000627290.2 M4PM66 ENST00000413737.2 ENST00000626701.1 A0A0D9SGA5 A0A0D9SGD0 A0A1B0GVB1 M4PV53 ENST00000616933.4 |
