CACNA1B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0098703Biological processcalcium ion import across plasma membrane
GO_0050804Biological processmodulation of chemical synaptic transmission
GO_0007268Biological processchemical synaptic transmission
GO_1904645Biological processresponse to amyloid-beta
GO_0005891Cellular componentvoltage-gated calcium channel complex
GO_0045202Cellular componentsynapse
GO_0043025Cellular componentneuronal cell body
GO_0005886Cellular componentplasma membrane
GO_0008331Molecular functionhigh voltage-gated calcium channel activity
GO_0005245Molecular functionvoltage-gated calcium channel activity
GO_0001540Molecular functionamyloid-beta binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameCACNA1B
Protein nameVoltage-dependent N-type calcium channel subunit alpha
Calcium channel alpha12.2 subunit
Voltage-dependent N-type calcium channel subunit alpha-1B (Brain calcium channel III) (BIII) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Voltage-gated calcium channel subunit alpha Cav2.2)
Calcium voltage-gated channel subunit alpha1 B
SynonymsCACH5
CACNL1A5
DescriptionFUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. Mediates Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity). .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. .

AccessionsQ9HBG2
ENST00000371363.5
H0Y7I8
B1AQK7
Q9HAT4
Q9HBG3
Q9HAT6
ENST00000371357.5
Q9HBI3
Q9HAT5
Q9HBH4
ENST00000371372.6 [Q00975-1]
Q9HBG1
Q9HBH3
B1AQK6
Q9HAT3
ENST00000277551.6 [Q00975-2]
Q9HBH2
Q9HBI4
Q00975
ENST00000413253.1