HTR1F report

I. Expression across cell types

Insufficient scRNA-seq data for expression of HTR1F at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HTR1F at tissue level.

III. Associated gene sets

GO_0007198Biological processadenylate cyclase-inhibiting serotonin receptor signaling pathway
GO_0007193Biological processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO_0007268Biological processchemical synaptic transmission
GO_0007187Biological processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO_0030425Cellular componentdendrite
GO_0045202Cellular componentsynapse
GO_0005886Cellular componentplasma membrane
GO_0051378Molecular functionserotonin binding
GO_0004993Molecular functionG protein-coupled serotonin receptor activity
GO_0030594Molecular functionneurotransmitter receptor activity

IV. Literature review

[source]
Gene nameHTR1F
Protein name5-hydroxytryptamine receptor 1F (5-HT-1F) (5-HT1F) (Serotonin receptor 1F)
5-hydroxytryptamine receptor 1F (Serotonin receptor 1F)
SynonymsHTR1EL
DescriptionFUNCTION: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. .

FUNCTION: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. .

AccessionsP30939
ENST00000319595.7
Q9P2Q4