CAMK2B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048169Biological processregulation of long-term neuronal synaptic plasticity
GO_0010976Biological processpositive regulation of neuron projection development
GO_0051924Biological processregulation of calcium ion transport
GO_0061003Biological processpositive regulation of dendritic spine morphogenesis
GO_2001222Biological processregulation of neuron migration
GO_0007165Biological processsignal transduction
GO_0051823Biological processregulation of synapse structural plasticity
GO_0060998Biological processregulation of dendritic spine development
GO_0030154Biological processcell differentiation
GO_0090129Biological processpositive regulation of synapse maturation
GO_0006468Biological processprotein phosphorylation
GO_0014733Biological processregulation of skeletal muscle adaptation
GO_0046777Biological processprotein autophosphorylation
GO_0007399Biological processnervous system development
GO_0030666Cellular componentendocytic vesicle membrane
GO_0005813Cellular componentcentrosome
GO_0005954Cellular componentcalcium- and calmodulin-dependent protein kinase complex
GO_0005654Cellular componentnucleoplasm
GO_0043005Cellular componentneuron projection
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0005737Cellular componentcytoplasm
GO_0033017Cellular componentsarcoplasmic reticulum membrane
GO_0042803Molecular functionprotein homodimerization activity
GO_0009931Molecular functioncalcium-dependent protein serine/threonine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0003779Molecular functionactin binding
GO_0005524Molecular functionATP binding
GO_0004683Molecular functioncalmodulin-dependent protein kinase activity
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCAMK2B
Protein namecalcium/calmodulin-dependent protein kinase (EC 2.7.11.17)
Calcium/calmodulin dependent protein kinase II beta
Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17)
Uncharacterized protein CAMK2B
SynonymsCAM2
CAMKB
CAMK2
tcag7.799
DescriptionFUNCTION: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle . In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons . Participates in the modulation of skeletal muscle function in response to exercise . In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity . .

AccessionsENST00000346990.8 [Q13554-7]
ENST00000700237.1
ENST00000700240.1
E7ERS6
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ENST00000358707.7 [Q13554-3]
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Q13554
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