SYT11 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
astrocyte	18 studies	41% ± 14%	Explore
oligodendrocyte	15 studies	43% ± 14%	Explore
oligodendrocyte precursor cell	12 studies	42% ± 21%	Explore
glutamatergic neuron	11 studies	46% ± 22%	Explore
GABAergic neuron	9 studies	46% ± 21%	Explore
neuron	8 studies	44% ± 16%	Explore
endothelial cell	7 studies	30% ± 11%	Explore
interneuron	6 studies	44% ± 26%	Explore
granule cell	4 studies	23% ± 6%	Explore
retinal ganglion cell	4 studies	70% ± 19%	Explore
retina horizontal cell	4 studies	29% ± 10%	Explore
Mueller cell	4 studies	39% ± 10%	Explore
retinal bipolar neuron	3 studies	23% ± 6%	Explore
GABAergic interneuron	3 studies	31% ± 10%	Explore
microglial cell	3 studies	21% ± 2%	Explore
amacrine cell	3 studies	31% ± 8%	Explore
rod bipolar cell	3 studies	27% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	38% ± 19%	Explore
eye	3 studies	27% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	25796.62	2642 / 2642	100%	542.19	704 / 705
ovary	74%	2311.33	133 / 180	89%	30.28	384 / 430
uterus	91%	3795.70	154 / 170	41%	15.07	189 / 459
prostate	53%	1864.13	131 / 245	66%	11.49	333 / 502
lung	49%	1304.27	283 / 578	57%	10.49	664 / 1155
skin	23%	862.41	422 / 1809	80%	34.62	378 / 472
bladder	71%	2408.05	15 / 21	30%	6.91	153 / 504
blood vessel	99%	6785.53	1317 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	93%	44.74	27 / 29
intestine	60%	2282.35	583 / 966	32%	6.31	170 / 527
kidney	16%	412.71	14 / 89	72%	20.00	647 / 901
breast	16%	422.47	75 / 459	68%	10.60	761 / 1118
pancreas	0%	0	0 / 328	84%	24.95	149 / 178
adrenal gland	14%	502.34	35 / 258	68%	110.72	156 / 230
esophagus	45%	1390.14	649 / 1445	32%	5.37	58 / 183
stomach	27%	913.82	97 / 359	48%	9.84	138 / 286
thymus	5%	123.25	30 / 653	45%	8.51	272 / 605
tonsil	0%	0	0 / 0	49%	6.28	22 / 45
heart	42%	1151.82	361 / 861	0%	0	0 / 0
adipose	29%	780.65	349 / 1204	0%	0	0 / 0
peripheral blood	21%	820.39	196 / 929	0%	0	0 / 0
spleen	18%	429.49	44 / 241	0%	0	0 / 0
eye	0%	0	0 / 0	13%	3.93	10 / 80
liver	0%	0	0 / 226	9%	1.34	36 / 406
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0001778	Biological process	plasma membrane repair
GO_0033602	Biological process	negative regulation of dopamine secretion
GO_1900424	Biological process	regulation of defense response to bacterium
GO_0048791	Biological process	calcium ion-regulated exocytosis of neurotransmitter
GO_1905171	Biological process	positive regulation of protein localization to phagocytic vesicle
GO_1900242	Biological process	regulation of synaptic vesicle endocytosis
GO_0007612	Biological process	learning
GO_0032715	Biological process	negative regulation of interleukin-6 production
GO_0045806	Biological process	negative regulation of endocytosis
GO_1903979	Biological process	negative regulation of microglial cell activation
GO_0046929	Biological process	negative regulation of neurotransmitter secretion
GO_0050765	Biological process	negative regulation of phagocytosis
GO_0001818	Biological process	negative regulation of cytokine production
GO_0007613	Biological process	memory
GO_0006914	Biological process	autophagy
GO_1990927	Biological process	calcium ion regulated lysosome exocytosis
GO_0006906	Biological process	vesicle fusion
GO_1905162	Biological process	regulation of phagosome maturation
GO_0032720	Biological process	negative regulation of tumor necrosis factor production
GO_0051650	Biological process	establishment of vesicle localization
GO_0070382	Cellular component	exocytic vesicle
GO_0098793	Cellular component	presynapse
GO_0031982	Cellular component	vesicle
GO_0005886	Cellular component	plasma membrane
GO_0043197	Cellular component	dendritic spine
GO_0032009	Cellular component	early phagosome
GO_0055037	Cellular component	recycling endosome
GO_0043204	Cellular component	perikaryon
GO_0048787	Cellular component	presynaptic active zone membrane
GO_0005764	Cellular component	lysosome
GO_0060077	Cellular component	inhibitory synapse
GO_0055038	Cellular component	recycling endosome membrane
GO_0098691	Cellular component	dopaminergic synapse
GO_0043005	Cellular component	neuron projection
GO_0030425	Cellular component	dendrite
GO_0005802	Cellular component	trans-Golgi network
GO_0008021	Cellular component	synaptic vesicle
GO_0045335	Cellular component	phagocytic vesicle
GO_0045202	Cellular component	synapse
GO_0001891	Cellular component	phagocytic cup
GO_0014069	Cellular component	postsynaptic density
GO_0060076	Cellular component	excitatory synapse
GO_0030424	Cellular component	axon
GO_0030665	Cellular component	clathrin-coated vesicle membrane
GO_0005765	Cellular component	lysosomal membrane
GO_0031369	Molecular function	translation initiation factor binding
GO_0048487	Molecular function	beta-tubulin binding
GO_0005544	Molecular function	calcium-dependent phospholipid binding
GO_0042802	Molecular function	identical protein binding
GO_0001786	Molecular function	phosphatidylserine binding
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0000149	Molecular function	SNARE binding
GO_0030276	Molecular function	clathrin binding
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SYT11
Protein name	Synaptotagmin-11 (Synaptotagmin XI) (SytXI)
Synonyms	KIAA0080
Description	FUNCTION: Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca(2+). Inhibits clathrin-mediated and bulk endocytosis, functions to ensure precision in vesicle retrieval. Plays an important role in dopamine transmission by regulating endocytosis and the vesicle-recycling process. Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity. In macrophages and microglia, inhibits the conventional cytokine secretion, of at least IL6 and TNF, and phagocytosis. In astrocytes, regulates lysosome exocytosis, mechanism required for the repair of injured astrocyte cell membrane (By similarity). Required for the ATP13A2-mediated regulation of the autophagy-lysosome pathway . .
Accessions	Q9BT88 ENST00000368324.5

SYT11 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review