UNC119 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042953Biological processlipoprotein transport
GO_0007601Biological processvisual perception
GO_1900186Biological processnegative regulation of clathrin-dependent endocytosis
GO_0007602Biological processphototransduction
GO_0000281Biological processmitotic cytokinesis
GO_0006897Biological processendocytosis
GO_0007268Biological processchemical synaptic transmission
GO_0007399Biological processnervous system development
GO_2001287Biological processnegative regulation of caveolin-mediated endocytosis
GO_0061098Biological processpositive regulation of protein tyrosine kinase activity
GO_0005813Cellular componentcentrosome
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0051233Cellular componentspindle midzone
GO_0000922Cellular componentspindle pole
GO_0045171Cellular componentintercellular bridge
GO_0005515Molecular functionprotein binding
GO_0008289Molecular functionlipid binding

IV. Literature review

[source]
Gene nameUNC119
Protein nameProtein unc-119 homolog A
Unc-119 lipid binding chaperone
Protein unc-119 homolog A (Retinal protein 4) (hRG4)
SynonymsRG4
hCG_31798
DescriptionFUNCTION: Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid-binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Probably plays a role in trafficking proteins in photoreceptor cells. Plays important roles in mediating Src family kinase signals for the completion of cytokinesis via RAB11A. .

AccessionsENST00000470125.5
Q13432
C9JSK0
J3QQT8
ENST00000484980.5
ENST00000444148.1
K7EJU3
ENST00000335765.9 [Q13432-1]
K7EN86
ENST00000301032.8 [Q13432-2]
ENST00000581945.1