Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 29 studies | 29% ± 11% | |
classical monocyte | 21 studies | 27% ± 10% | |
endothelial cell | 16 studies | 25% ± 10% | |
monocyte | 15 studies | 26% ± 8% | |
non-classical monocyte | 14 studies | 21% ± 6% | |
fibroblast | 12 studies | 20% ± 7% | |
astrocyte | 12 studies | 27% ± 12% | |
myeloid cell | 11 studies | 33% ± 13% | |
oligodendrocyte | 10 studies | 26% ± 9% | |
glutamatergic neuron | 9 studies | 37% ± 23% | |
dendritic cell | 9 studies | 27% ± 10% | |
type I pneumocyte | 8 studies | 24% ± 6% | |
conventional dendritic cell | 8 studies | 32% ± 10% | |
microglial cell | 8 studies | 27% ± 8% | |
epithelial cell | 8 studies | 34% ± 20% | |
leukocyte | 6 studies | 21% ± 4% | |
mononuclear phagocyte | 6 studies | 26% ± 7% | |
type II pneumocyte | 6 studies | 27% ± 8% | |
GABAergic neuron | 6 studies | 41% ± 18% | |
natural killer cell | 6 studies | 18% ± 2% | |
neuron | 5 studies | 30% ± 9% | |
mast cell | 5 studies | 24% ± 9% | |
basal cell | 5 studies | 36% ± 15% | |
club cell | 5 studies | 22% ± 5% | |
oligodendrocyte precursor cell | 5 studies | 29% ± 11% | |
squamous epithelial cell | 4 studies | 38% ± 19% | |
retinal ganglion cell | 4 studies | 50% ± 26% | |
lymphocyte | 4 studies | 21% ± 5% | |
mucosal invariant T cell | 4 studies | 17% ± 2% | |
ciliated cell | 4 studies | 28% ± 10% | |
alveolar macrophage | 4 studies | 36% ± 14% | |
interneuron | 4 studies | 42% ± 22% | |
naive B cell | 3 studies | 18% ± 0% | |
hematopoietic precursor cell | 3 studies | 33% ± 8% | |
common myeloid progenitor | 3 studies | 24% ± 6% | |
CD16-positive, CD56-dim natural killer cell, human | 3 studies | 17% ± 2% | |
tissue-resident macrophage | 3 studies | 24% ± 4% | |
intermediate monocyte | 3 studies | 32% ± 10% | |
B cell | 3 studies | 16% ± 1% | |
neutrophil | 3 studies | 23% ± 5% | |
pericyte | 3 studies | 25% ± 6% | |
endothelial cell of lymphatic vessel | 3 studies | 24% ± 6% | |
plasmacytoid dendritic cell | 3 studies | 20% ± 6% | |
gamma-delta T cell | 3 studies | 22% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
bladder | 100% | 5469.57 | 21 / 21 | 100% | 99.54 | 504 / 504 |
esophagus | 100% | 6384.33 | 1445 / 1445 | 100% | 107.36 | 183 / 183 |
ovary | 100% | 4270.08 | 180 / 180 | 100% | 65.70 | 430 / 430 |
uterus | 100% | 5222.23 | 170 / 170 | 100% | 103.45 | 459 / 459 |
brain | 100% | 6940.33 | 2639 / 2642 | 100% | 129.69 | 705 / 705 |
thymus | 100% | 5308.34 | 653 / 653 | 100% | 122.26 | 604 / 605 |
lung | 100% | 5876.82 | 577 / 578 | 100% | 102.90 | 1155 / 1155 |
breast | 100% | 5243.87 | 459 / 459 | 100% | 135.53 | 1116 / 1118 |
skin | 100% | 8743.97 | 1809 / 1809 | 100% | 99.18 | 471 / 472 |
prostate | 100% | 4362.82 | 245 / 245 | 100% | 86.63 | 500 / 502 |
kidney | 100% | 3834.38 | 89 / 89 | 100% | 73.21 | 897 / 901 |
stomach | 100% | 3372.45 | 359 / 359 | 99% | 70.12 | 284 / 286 |
intestine | 100% | 4613.20 | 966 / 966 | 99% | 68.35 | 523 / 527 |
adrenal gland | 100% | 5622.55 | 258 / 258 | 99% | 91.63 | 228 / 230 |
liver | 100% | 2509.99 | 226 / 226 | 99% | 49.18 | 402 / 406 |
pancreas | 98% | 2225.53 | 320 / 328 | 99% | 81.93 | 177 / 178 |
adipose | 100% | 5354.53 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 6083.69 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 78.44 | 29 / 29 |
muscle | 100% | 8532.72 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 4081.95 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 124.14 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 56.64 | 1 / 1 |
heart | 95% | 3750.02 | 817 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 93% | 43.85 | 74 / 80 |
peripheral blood | 90% | 3341.43 | 837 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0001778 | Biological process | plasma membrane repair |
GO_0090117 | Biological process | endosome to lysosome transport of low-density lipoprotein particle |
GO_0061909 | Biological process | autophagosome-lysosome fusion |
GO_0007059 | Biological process | chromosome segregation |
GO_0046754 | Biological process | viral exocytosis |
GO_1902946 | Biological process | protein localization to early endosome |
GO_0008089 | Biological process | anterograde axonal transport |
GO_0034498 | Biological process | early endosome to Golgi transport |
GO_0002505 | Biological process | antigen processing and presentation of polysaccharide antigen via MHC class II |
GO_0051301 | Biological process | cell division |
GO_0042267 | Biological process | natural killer cell mediated cytotoxicity |
GO_0002747 | Biological process | antigen processing and presentation following phagocytosis |
GO_0090385 | Biological process | phagosome-lysosome fusion |
GO_0032418 | Biological process | lysosome localization |
GO_1902774 | Biological process | late endosome to lysosome transport |
GO_0015031 | Biological process | protein transport |
GO_1990927 | Biological process | calcium ion regulated lysosome exocytosis |
GO_0030496 | Cellular component | midbody |
GO_0031902 | Cellular component | late endosome membrane |
GO_0016020 | Cellular component | membrane |
GO_0031901 | Cellular component | early endosome membrane |
GO_0005764 | Cellular component | lysosome |
GO_0070062 | Cellular component | extracellular exosome |
GO_0051233 | Cellular component | spindle midzone |
GO_0005829 | Cellular component | cytosol |
GO_0045202 | Cellular component | synapse |
GO_0005737 | Cellular component | cytoplasm |
GO_0101004 | Cellular component | cytolytic granule membrane |
GO_1904115 | Cellular component | axon cytoplasm |
GO_0005765 | Cellular component | lysosomal membrane |
GO_0019003 | Molecular function | GDP binding |
GO_0048487 | Molecular function | beta-tubulin binding |
GO_0003925 | Molecular function | G protein activity |
GO_0005525 | Molecular function | GTP binding |
GO_0043014 | Molecular function | alpha-tubulin binding |
GO_0005515 | Molecular function | protein binding |
GO_0003924 | Molecular function | GTPase activity |
Gene name | ARL8B |
Protein name | ADP-ribosylation factor-like protein 8B (EC 3.6.5.2) (ADP-ribosylation factor-like protein 10C) (Novel small G protein indispensable for equal chromosome segregation 1) ADP ribosylation factor like GTPase 8B |
Synonyms | GIE1 ARL10C |
Description | FUNCTION: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states . In its active state, binds to a variety of effector proteins playing a key role in the regulation of lysosomal positioning which is important for nutrient sensing, natural killer cell-mediated cytotoxicity and antigen presentation. Along with its effectors, orchestrates lysosomal transport and fusion . Localizes specifically to lysosomal membranes and mediates anterograde lysosomal motility by recruiting PLEKHM2, which in turn recruits the motor protein kinesin-1 on lysosomes. Required for lysosomal and cytolytic granule exocytosis . Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells . In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). Also acts as a regulator of endosome to lysosome trafficking pathways of special significance for host defense . Regulates cargo trafficking to lysosomes by binding to PLEKHM1 and recruiting the HOPS subunit VPS41, resulting in functional assembly of the HOPS complex on lysosomal membranes . Plays an important role in cargo delivery to lysosomes for antigen presentation and microbial killing. Directs the intersection of CD1d with lipid antigens in lysosomes, and plays a role in intersecting phagosomes with lysosomes to generate phagolysosomes that kill microbes . Involved in the process of MHC II presentation. Regulates the delivery of antigens to lysosomes and the formation of MHC II-peptide complexes through the recruitment of the HOPS complex to lysosomes allowing the fusion of late endosomes to lysosomes (By similarity). May play a role in chromosome segregation . .; FUNCTION: (Microbial infection) During Mycobacterium tuberculosis (Mtb) infection, is required for plasma membrane repair by controlling the exocytosis of lysosomes in macrophages. ARL8B secretion pathway is crucial to control the type of cell death of the M. tuberculosis-infected macrophages, distinguishing avirulent from virulent Mtb induced necrotic cell death. .; FUNCTION: (Microbial infection) During infection, coronaviruses such as SARS-CoV-2 and the chaperone HSPA5/GRP78 are probably co-released through ARL8B-dependent lysosomal exocytic pathway for unconventional egress. . |
Accessions | ENST00000455168.5 Q9NVJ2 F2Z344 ENST00000468010.1 A0A6Q8PGM9 ENST00000429403.5 ENST00000256496.8 [Q9NVJ2-1] ENST00000419534.2 [Q9NVJ2-2] F8WAW5 |