SSH1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030837Biological processnegative regulation of actin filament polymerization
GO_0006470Biological processprotein dephosphorylation
GO_0031915Biological processpositive regulation of synaptic plasticity
GO_0098976Biological processexcitatory chemical synaptic transmission
GO_2000463Biological processpositive regulation of excitatory postsynaptic potential
GO_1904719Biological processpositive regulation of AMPA glutamate receptor clustering
GO_0071318Biological processcellular response to ATP
GO_0030036Biological processactin cytoskeleton organization
GO_0000902Biological processcell morphogenesis
GO_0051246Biological processregulation of protein metabolic process
GO_1904754Biological processpositive regulation of vascular associated smooth muscle cell migration
GO_0030496Cellular componentmidbody
GO_0005856Cellular componentcytoskeleton
GO_0005886Cellular componentplasma membrane
GO_0045202Cellular componentsynapse
GO_0030426Cellular componentgrowth cone
GO_0005737Cellular componentcytoplasm
GO_0032154Cellular componentcleavage furrow
GO_0030027Cellular componentlamellipodium
GO_0004721Molecular functionphosphoprotein phosphatase activity
GO_0017018Molecular functionmyosin phosphatase activity
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding
GO_0004725Molecular functionprotein tyrosine phosphatase activity

IV. Literature review

[source]
Gene nameSSH1
Protein nameprotein-serine/threonine phosphatase (EC 3.1.3.16)
Slingshot protein phosphatase 1
Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L)
SynonymsSSH1L
KIAA1298
DescriptionFUNCTION: Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. .

AccessionsQ8WYL5
ENST00000546433.5
ENST00000326470.9 [Q8WYL5-5]
ENST00000548522.5
F8VS18
F8W1D9
H0YHR3
ENST00000546697.1
ENST00000326495.10 [Q8WYL5-1]
ENST00000551165.5 [Q8WYL5-2]