Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| oligodendrocyte precursor cell | 9 studies | 31% ± 13% | |
| glutamatergic neuron | 8 studies | 36% ± 12% | |
| neuron | 7 studies | 25% ± 7% | |
| GABAergic neuron | 6 studies | 27% ± 15% | |
| interneuron | 5 studies | 35% ± 19% | |
| granule cell | 4 studies | 22% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 8 studies | 25% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 95% | 21217.40 | 2517 / 2642 | 97% | 47.75 | 681 / 705 |
| adrenal gland | 12% | 432.41 | 30 / 258 | 66% | 52.82 | 151 / 230 |
| prostate | 3% | 81.08 | 8 / 245 | 10% | 0.64 | 51 / 502 |
| eye | 0% | 0 | 0 / 0 | 9% | 0.44 | 7 / 80 |
| pancreas | 0% | 5.11 | 1 / 328 | 6% | 0.56 | 11 / 178 |
| stomach | 0% | 0 | 0 / 359 | 4% | 0.67 | 12 / 286 |
| uterus | 1% | 13.04 | 1 / 170 | 3% | 0.51 | 16 / 459 |
| lung | 0% | 0 | 0 / 578 | 4% | 0.35 | 46 / 1155 |
| skin | 0% | 0 | 0 / 1809 | 3% | 0.34 | 15 / 472 |
| intestine | 0% | 1.48 | 1 / 966 | 3% | 0.19 | 16 / 527 |
| esophagus | 0% | 0 | 0 / 1445 | 3% | 0.19 | 5 / 183 |
| bladder | 0% | 0 | 0 / 21 | 2% | 0.08 | 11 / 504 |
| ovary | 0% | 0 | 0 / 180 | 1% | 0.07 | 6 / 430 |
| breast | 0% | 0 | 0 / 459 | 1% | 0.13 | 13 / 1118 |
| kidney | 0% | 0 | 0 / 89 | 0% | 0.15 | 4 / 901 |
| peripheral blood | 0% | 6.69 | 2 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| adipose | 0% | 0 | 0 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 0 | 0 / 1335 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| heart | 0% | 0 | 0 / 861 | 0% | 0 | 0 / 0 |
| liver | 0% | 0 | 0 / 226 | 0% | 0 | 0 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| thymus | 0% | 0 | 0 / 653 | 0% | 0 | 0 / 605 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007399 | Biological process | nervous system development |
| GO_0001508 | Biological process | action potential |
| GO_0007268 | Biological process | chemical synaptic transmission |
| GO_0071805 | Biological process | potassium ion transmembrane transport |
| GO_0045202 | Cellular component | synapse |
| GO_0043194 | Cellular component | axon initial segment |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0008076 | Cellular component | voltage-gated potassium channel complex |
| GO_0016020 | Cellular component | membrane |
| GO_0033268 | Cellular component | node of Ranvier |
| GO_0030506 | Molecular function | ankyrin binding |
| GO_0005516 | Molecular function | calmodulin binding |
| GO_0005249 | Molecular function | voltage-gated potassium channel activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | KCNQ2 |
| Protein name | Potassium voltage-gated channel subfamily KQT member 2 (Potassium voltage-gated channel subfamily Q member 2) Potassium voltage-gated channel subfamily Q member 2 Potassium voltage-gated channel subfamily KQT member 2 Potassium voltage-gated channel, KQT-like subfamily, member 2 Potassium voltage-gated channel subfamily KQT member 2 (KQT-like 2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (Voltage-gated potassium channel subunit Kv7.2) |
| Synonyms | hCG_23426 |
| Description | FUNCTION: Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine . As the native M-channel, the potassium channel composed of KCNQ2 and KCNQ3 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1 . KCNQ2-KCNQ3 channel is selectively permeable to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+). Associates with Na(+)-coupled myo-inositol symporter SLC5A3 forming a coregulatory complex that alters ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) permeation. . |
| Accessions | ENST00000626723.2 ENST00000629318.1 A0A0G2JQC9 ENST00000626684.1 A0A1B0GUK1 ENST00000628790.2 A0A0D9SGD4 A0A0G2JSD3 A0A0G2JS89 ENST00000629498.2 ENST00000359125.7 [O43526-1] ENST00000629338.2 ENST00000630648.2 Q53Y30 A0A0D9SGG3 A0A0G2JRN9 ENST00000626839.2 [O43526-2] ENST00000357249.6 ENST00000360480.7 [O43526-3] ENST00000344462.8 [O43526-4] ENST00000627948.2 ENST00000629641.2 A0A0G2JR98 Q4VXP6 ENST00000344425.8 [O43526-6] ENST00000625514.2 ENST00000629676.2 ENST00000626962.2 A0A0G2JH35 ENST00000630933.1 A0A0D9SFE0 A0A1B0GW14 ENST00000627221.2 ENST00000636614.1 ENST00000370224.5 A0A0G2JRU6 ENST00000625248.1 ENST00000629241.2 ENST00000706989.1 A0A0G2JR60 A0A0G2JR54 A0A0D9SG49 ENST00000629518.2 A0A0G2JQG6 O43526 A0A0D9SGJ7 ENST00000637193.1 ENST00000628544.2 ENST00000627416.2 ENST00000628732.2 A0A0D9SF10 A0A9L9PXL0 A0A0D9SEV1 |
