COMT | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	32 studies	28% ± 13%	Explore
macrophage	31 studies	39% ± 15%	Explore
endothelial cell	28 studies	29% ± 12%	Explore
pericyte	25 studies	27% ± 10%	Explore
classical monocyte	25 studies	34% ± 14%	Explore
conventional dendritic cell	25 studies	35% ± 15%	Explore
smooth muscle cell	22 studies	23% ± 10%	Explore
basal cell	20 studies	39% ± 19%	Explore
epithelial cell	19 studies	37% ± 21%	Explore
monocyte	18 studies	29% ± 10%	Explore
plasmacytoid dendritic cell	18 studies	41% ± 13%	Explore
non-classical monocyte	18 studies	31% ± 12%	Explore
endothelial cell of lymphatic vessel	14 studies	37% ± 14%	Explore
ciliated cell	13 studies	43% ± 19%	Explore
natural killer cell	12 studies	20% ± 5%	Explore
myeloid cell	12 studies	34% ± 14%	Explore
dendritic cell	11 studies	48% ± 23%	Explore
CD8-positive, alpha-beta T cell	11 studies	20% ± 5%	Explore
type I pneumocyte	10 studies	45% ± 18%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	20% ± 4%	Explore
myofibroblast cell	10 studies	25% ± 9%	Explore
astrocyte	10 studies	26% ± 14%	Explore
type II pneumocyte	9 studies	38% ± 20%	Explore
secretory cell	9 studies	36% ± 18%	Explore
connective tissue cell	9 studies	28% ± 9%	Explore
club cell	8 studies	34% ± 17%	Explore
capillary endothelial cell	8 studies	25% ± 10%	Explore
oligodendrocyte	8 studies	24% ± 10%	Explore
endothelial cell of artery	8 studies	32% ± 15%	Explore
alveolar macrophage	7 studies	49% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	18% ± 2%	Explore
regulatory T cell	7 studies	22% ± 7%	Explore
oligodendrocyte precursor cell	7 studies	28% ± 11%	Explore
mast cell	6 studies	17% ± 2%	Explore
mononuclear phagocyte	6 studies	30% ± 17%	Explore
goblet cell	6 studies	27% ± 14%	Explore
endothelial cell of vascular tree	6 studies	23% ± 5%	Explore
glial cell	6 studies	41% ± 18%	Explore
hematopoietic precursor cell	5 studies	53% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	21% ± 6%	Explore
ionocyte	5 studies	29% ± 10%	Explore
CD4-positive, alpha-beta T cell	5 studies	20% ± 3%	Explore
kidney loop of Henle epithelial cell	5 studies	44% ± 8%	Explore
enterocyte	5 studies	25% ± 11%	Explore
enteroendocrine cell	5 studies	33% ± 14%	Explore
intestinal crypt stem cell	5 studies	27% ± 4%	Explore
progenitor cell	5 studies	35% ± 13%	Explore
vein endothelial cell	5 studies	24% ± 8%	Explore
hematopoietic stem cell	5 studies	48% ± 11%	Explore
pro-B cell	5 studies	30% ± 6%	Explore
microglial cell	5 studies	27% ± 10%	Explore
abnormal cell	5 studies	40% ± 15%	Explore
neuron	5 studies	32% ± 13%	Explore
respiratory goblet cell	4 studies	34% ± 17%	Explore
pancreatic A cell	4 studies	33% ± 11%	Explore
exhausted T cell	4 studies	25% ± 8%	Explore
mature NK T cell	4 studies	18% ± 1%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	20% ± 5%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	36% ± 18%	Explore
leukocyte	4 studies	21% ± 5%	Explore
Mueller cell	4 studies	39% ± 14%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	39% ± 11%	Explore
GABAergic neuron	4 studies	28% ± 13%	Explore
hepatocyte	4 studies	34% ± 20%	Explore
gamma-delta T cell	4 studies	25% ± 14%	Explore
type B pancreatic cell	3 studies	32% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	17% ± 1%	Explore
glomerular endothelial cell	3 studies	24% ± 4%	Explore
podocyte	3 studies	44% ± 7%	Explore
T cell	3 studies	27% ± 11%	Explore
neural crest cell	3 studies	22% ± 2%	Explore
retinal bipolar neuron	3 studies	30% ± 9%	Explore
placental villous trophoblast	3 studies	81% ± 19%	Explore
common myeloid progenitor	3 studies	51% ± 16%	Explore
lymphocyte	3 studies	30% ± 3%	Explore
innate lymphoid cell	3 studies	19% ± 3%	Explore
B cell	3 studies	24% ± 9%	Explore
plasma cell	3 studies	28% ± 14%	Explore
brush cell	3 studies	26% ± 6%	Explore
Schwann cell	3 studies	48% ± 17%	Explore
serous secreting cell	3 studies	29% ± 8%	Explore
tissue-resident macrophage	3 studies	28% ± 11%	Explore
rod bipolar cell	3 studies	31% ± 5%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	29% ± 9%	Explore
intermediate monocyte	3 studies	46% ± 14%	Explore
mesothelial cell	3 studies	30% ± 18%	Explore
muscle cell	3 studies	29% ± 13%	Explore
glutamatergic neuron	3 studies	38% ± 12%	Explore
pancreatic ductal cell	3 studies	54% ± 10%	Explore
melanocyte	3 studies	36% ± 10%	Explore
transit amplifying cell	3 studies	19% ± 4%	Explore
keratinocyte	3 studies	26% ± 5%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	60% ± 23%	Explore
progenitor cell of mammary luminal epithelium	3 studies	33% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	24% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	16 studies	33% ± 14%	Explore
peripheral blood	11 studies	25% ± 8%	Explore
intestine	8 studies	22% ± 9%	Explore
kidney	6 studies	23% ± 5%	Explore
eye	6 studies	24% ± 4%	Explore
brain	6 studies	31% ± 7%	Explore
placenta	4 studies	48% ± 20%	Explore
uterus	4 studies	32% ± 13%	Explore
breast	4 studies	23% ± 3%	Explore
liver	4 studies	24% ± 7%	Explore
pancreas	3 studies	36% ± 10%	Explore
bone marrow	3 studies	22% ± 4%	Explore
prostate	3 studies	22% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5619.99	1445 / 1445	100%	34.40	183 / 183
brain	100%	4821.37	2640 / 2642	100%	70.56	705 / 705
uterus	100%	4570.02	170 / 170	100%	51.84	458 / 459
prostate	100%	5246.54	245 / 245	100%	61.66	500 / 502
skin	100%	6363.94	1809 / 1809	100%	78.70	470 / 472
thymus	100%	3679.94	652 / 653	99%	39.99	601 / 605
stomach	100%	4104.99	359 / 359	99%	46.14	283 / 286
intestine	100%	4114.60	965 / 966	99%	52.01	522 / 527
breast	100%	5184.44	459 / 459	99%	44.37	1105 / 1118
ovary	100%	6279.05	180 / 180	99%	28.70	425 / 430
lung	100%	5595.73	577 / 578	99%	53.75	1143 / 1155
liver	100%	7729.95	226 / 226	99%	48.70	401 / 406
adrenal gland	100%	10484.24	258 / 258	99%	49.45	227 / 230
kidney	100%	4281.73	89 / 89	99%	34.26	889 / 901
bladder	100%	4752.05	21 / 21	99%	76.09	497 / 504
pancreas	99%	2345.81	324 / 328	99%	47.12	177 / 178
adipose	100%	4491.51	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	108.22	80 / 80
lymph node	0%	0	0 / 0	100%	33.95	29 / 29
spleen	100%	3686.79	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	57.02	45 / 45
ureter	0%	0	0 / 0	100%	46.79	1 / 1
blood vessel	100%	5194.50	1333 / 1335	0%	0	0 / 0
muscle	100%	3267.37	799 / 803	0%	0	0 / 0
heart	99%	3093.48	849 / 861	0%	0	0 / 0
peripheral blood	87%	1995.80	809 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0097205	Biological process	renal filtration
GO_0016036	Biological process	cellular response to phosphate starvation
GO_0035640	Biological process	exploration behavior
GO_0060840	Biological process	artery development
GO_0032259	Biological process	methylation
GO_0032502	Biological process	developmental process
GO_0046959	Biological process	habituation
GO_0005977	Biological process	glycogen metabolic process
GO_0014046	Biological process	dopamine secretion
GO_0034097	Biological process	response to cytokine
GO_0071626	Biological process	mastication
GO_0035264	Biological process	multicellular organism growth
GO_0042417	Biological process	dopamine metabolic process
GO_0008542	Biological process	visual learning
GO_0042424	Biological process	catecholamine catabolic process
GO_1902074	Biological process	response to salt
GO_1903350	Biological process	response to dopamine
GO_0097018	Biological process	renal albumin absorption
GO_0071314	Biological process	cellular response to cocaine
GO_0021696	Biological process	cerebellar cortex morphogenesis
GO_0002001	Biological process	renin secretion into blood stream
GO_0050965	Biological process	detection of temperature stimulus involved in sensory perception of pain
GO_0001666	Biological process	response to hypoxia
GO_0006693	Biological process	prostaglandin metabolic process
GO_0001662	Biological process	behavioral fear response
GO_0001963	Biological process	synaptic transmission, dopaminergic
GO_0001964	Biological process	startle response
GO_0007613	Biological process	memory
GO_0001975	Biological process	response to amphetamine
GO_0010467	Biological process	gene expression
GO_0032835	Biological process	glomerulus development
GO_0033344	Biological process	cholesterol efflux
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0009636	Biological process	response to toxic substance
GO_0032094	Biological process	response to food
GO_0042415	Biological process	norepinephrine metabolic process
GO_0006979	Biological process	response to oxidative stress
GO_0048243	Biological process	norepinephrine secretion
GO_0009611	Biological process	response to wounding
GO_0051412	Biological process	response to corticosterone
GO_1990776	Biological process	response to angiotensin
GO_0035812	Biological process	renal sodium excretion
GO_0042420	Biological process	dopamine catabolic process
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0070062	Cellular component	extracellular exosome
GO_0030425	Cellular component	dendrite
GO_0005829	Cellular component	cytosol
GO_0045202	Cellular component	synapse
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0030424	Cellular component	axon
GO_0008171	Molecular function	O-methyltransferase activity
GO_0016206	Molecular function	catechol O-methyltransferase activity
GO_0000287	Molecular function	magnesium ion binding
GO_0008168	Molecular function	methyltransferase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	COMT
Protein name	Catechol-O-methyltransferase isoform catechol O-methyltransferase (EC 2.1.1.6) Catechol O-methyltransferase (EC 2.1.1.6) Catechol-O-methyltransferase
Synonyms
Description	FUNCTION: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. . FUNCTION: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. . FUNCTION: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. . FUNCTION: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. . FUNCTION: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. . FUNCTION: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. .
Accessions	A3F6Y9 F2WW53 ENST00000449653.5 [P21964-2] ENST00000406520.7 [P21964-1] E7EUU8 A0A4D6GL01 H7BZ45 A0A1S6YJG6 A0A4D6GI82 A0A4D6GKQ6 ENST00000678769.1 ENST00000412786.5 B8XPJ8 ENST00000428707.2 F8WBW9 B8XPJ7 ENST00000678868.1 [P21964-1] A3F7Q5 A0A4D6GL07 ENST00000361682.11 [P21964-1] A0A4D6GI07 A0A4D6GI48 ENST00000677397.1 E7EMS6 A0A4D6GIA3 ENST00000403710.5 [P21964-1] A0A4D6GI63 A0A4D6GKX6 F2WW55 A0A4D6GIL3 A0A4D6GI39 A0A4D6GI41 ENST00000407537.5 [P21964-1] A0A4D6GI65 A0A4D6GIK3 A0A7I2V3G7 ENST00000403184.5 A0A4D6GI32 A0A286SD53 A0A4D6GL81 ENST00000678255.1 [P21964-1] ENST00000676678.1 [P21964-1] A0A4D6GIW7 ENST00000207636.9 P21964 A3F7Q6 A0A4D6GI75 A0A7I2V370

COMT report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review