Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 34 studies | 36% ± 16% | |
astrocyte | 18 studies | 57% ± 21% | |
pericyte | 14 studies | 28% ± 11% | |
oligodendrocyte precursor cell | 13 studies | 48% ± 18% | |
endothelial cell of lymphatic vessel | 12 studies | 43% ± 17% | |
macrophage | 12 studies | 31% ± 16% | |
endothelial cell of artery | 12 studies | 31% ± 16% | |
microglial cell | 12 studies | 44% ± 15% | |
oligodendrocyte | 11 studies | 34% ± 15% | |
GABAergic neuron | 10 studies | 57% ± 26% | |
glutamatergic neuron | 9 studies | 53% ± 20% | |
capillary endothelial cell | 9 studies | 32% ± 14% | |
fibroblast | 9 studies | 24% ± 7% | |
type II pneumocyte | 8 studies | 35% ± 16% | |
vein endothelial cell | 7 studies | 32% ± 22% | |
neuron | 5 studies | 34% ± 18% | |
interneuron | 5 studies | 53% ± 27% | |
epithelial cell | 5 studies | 28% ± 12% | |
retina horizontal cell | 5 studies | 62% ± 17% | |
myeloid cell | 5 studies | 38% ± 18% | |
type I pneumocyte | 5 studies | 34% ± 11% | |
smooth muscle cell | 4 studies | 23% ± 8% | |
granule cell | 4 studies | 31% ± 22% | |
amacrine cell | 4 studies | 52% ± 17% | |
club cell | 4 studies | 39% ± 9% | |
GABAergic interneuron | 3 studies | 65% ± 22% | |
retinal ganglion cell | 3 studies | 30% ± 10% | |
cardiac muscle cell | 3 studies | 20% ± 3% | |
mesothelial cell | 3 studies | 21% ± 1% | |
ciliated cell | 3 studies | 26% ± 6% | |
glycinergic amacrine cell | 3 studies | 25% ± 3% | |
lymphocyte | 3 studies | 18% ± 1% | |
endothelial cell of vascular tree | 3 studies | 47% ± 25% | |
retinal pigment epithelial cell | 3 studies | 28% ± 10% | |
ependymal cell | 3 studies | 51% ± 16% | |
monocyte | 3 studies | 20% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 4620.44 | 244 / 245 | 100% | 32.35 | 502 / 502 |
brain | 100% | 7430.99 | 2640 / 2642 | 99% | 38.38 | 698 / 705 |
thymus | 100% | 7333.19 | 653 / 653 | 97% | 83.35 | 584 / 605 |
lung | 100% | 13893.62 | 578 / 578 | 92% | 30.98 | 1062 / 1155 |
kidney | 100% | 3090.58 | 89 / 89 | 91% | 24.91 | 822 / 901 |
breast | 100% | 8267.49 | 457 / 459 | 91% | 17.45 | 1012 / 1118 |
ovary | 100% | 5402.04 | 180 / 180 | 84% | 14.39 | 361 / 430 |
pancreas | 90% | 3093.04 | 295 / 328 | 94% | 22.60 | 167 / 178 |
esophagus | 97% | 5414.84 | 1406 / 1445 | 84% | 14.04 | 153 / 183 |
intestine | 99% | 4438.65 | 954 / 966 | 80% | 11.27 | 422 / 527 |
stomach | 100% | 5043.13 | 358 / 359 | 79% | 12.37 | 226 / 286 |
adrenal gland | 91% | 2343.44 | 235 / 258 | 87% | 21.38 | 199 / 230 |
bladder | 100% | 7130.38 | 21 / 21 | 68% | 10.47 | 344 / 504 |
uterus | 100% | 6475.52 | 170 / 170 | 65% | 11.36 | 298 / 459 |
skin | 98% | 7923.00 | 1766 / 1809 | 63% | 22.80 | 297 / 472 |
adipose | 100% | 8683.58 | 1204 / 1204 | 0% | 0 | 0 / 0 |
spleen | 100% | 5798.45 | 241 / 241 | 0% | 0 | 0 / 0 |
heart | 98% | 7196.30 | 845 / 861 | 0% | 0 | 0 / 0 |
blood vessel | 97% | 4811.66 | 1296 / 1335 | 0% | 0 | 0 / 0 |
muscle | 92% | 2534.87 | 735 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 67% | 7.74 | 30 / 45 |
lymph node | 0% | 0 | 0 / 0 | 59% | 7.32 | 17 / 29 |
eye | 0% | 0 | 0 / 0 | 57% | 11.44 | 46 / 80 |
liver | 24% | 476.96 | 54 / 226 | 31% | 4.00 | 125 / 406 |
peripheral blood | 6% | 123.87 | 54 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0018105 | Biological process | peptidyl-serine phosphorylation |
GO_0008285 | Biological process | negative regulation of cell population proliferation |
GO_0045786 | Biological process | negative regulation of cell cycle |
GO_0007165 | Biological process | signal transduction |
GO_0035556 | Biological process | intracellular signal transduction |
GO_0007268 | Biological process | chemical synaptic transmission |
GO_0043065 | Biological process | positive regulation of apoptotic process |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0045202 | Cellular component | synapse |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0004712 | Molecular function | protein serine/threonine/tyrosine kinase activity |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0004711 | Molecular function | ribosomal protein S6 kinase activity |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0000287 | Molecular function | magnesium ion binding |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
Gene name | RPS6KA2 |
Protein name | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) Ribosomal protein S6 kinase 90kDa polypeptide 2 isoform B Ribosomal protein S6 kinase A2 Ribosomal protein S6 kinase 90kDa polypeptide 2 isoform C Ribosomal protein S6 kinase A2 (Ribosomal protein S6 kinase, 90kDa, polypeptide 2, isoform CRA_a) (cDNA FLJ55331, highly similar to Ribosomal protein S6 kinase alpha-2) Ribosomal protein S6 kinase (EC 2.7.11.1) Ribosomal protein S6 kinase 90kDa polypeptide 2 isoform A |
Synonyms | hCG_2029617 RSK3 MAPKAPK1C |
Description | FUNCTION: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. . |
Accessions | X5DNZ1 X5D337 ENST00000265678.9 [Q15349-1] D6RA62 ENST00000503859.5 [Q15349-3] ENST00000405189.7 X5DPB4 D6RE03 ENST00000511034.1 ENST00000506565.1 B7Z3B5 F2Z2J1 D6RHW7 ENST00000481261.6 ENST00000507350.5 D6RD75 ENST00000507371.5 ENST00000512860.5 ENST00000510118.5 D6R910 Q15349 |