MPST | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
epithelial cell	14 studies	45% ± 22%	Explore
fibroblast	11 studies	25% ± 7%	Explore
natural killer cell	10 studies	20% ± 5%	Explore
basal cell	9 studies	34% ± 18%	Explore
endothelial cell	9 studies	24% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	19% ± 3%	Explore
connective tissue cell	8 studies	24% ± 6%	Explore
goblet cell	8 studies	47% ± 19%	Explore
classical monocyte	7 studies	24% ± 7%	Explore
enterocyte	7 studies	58% ± 20%	Explore
progenitor cell	7 studies	47% ± 17%	Explore
endothelial cell of lymphatic vessel	7 studies	24% ± 6%	Explore
type II pneumocyte	6 studies	39% ± 12%	Explore
club cell	6 studies	22% ± 7%	Explore
conventional dendritic cell	6 studies	29% ± 13%	Explore
epithelial cell of proximal tubule	6 studies	33% ± 7%	Explore
type I pneumocyte	5 studies	28% ± 9%	Explore
mesothelial cell	5 studies	29% ± 14%	Explore
pericyte	5 studies	20% ± 5%	Explore
smooth muscle cell	5 studies	17% ± 2%	Explore
transit amplifying cell	5 studies	41% ± 20%	Explore
erythroblast	5 studies	35% ± 16%	Explore
hepatocyte	5 studies	46% ± 29%	Explore
hematopoietic precursor cell	4 studies	32% ± 7%	Explore
plasma cell	4 studies	26% ± 12%	Explore
secretory cell	4 studies	24% ± 8%	Explore
macrophage	4 studies	21% ± 6%	Explore
enteroendocrine cell	4 studies	40% ± 10%	Explore
intestinal crypt stem cell	4 studies	53% ± 16%	Explore
myofibroblast cell	4 studies	17% ± 0%	Explore
B cell	4 studies	19% ± 3%	Explore
abnormal cell	4 studies	22% ± 6%	Explore
erythrocyte	4 studies	41% ± 23%	Explore
ionocyte	3 studies	23% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	17% ± 2%	Explore
neural crest cell	3 studies	28% ± 6%	Explore
hematopoietic stem cell	3 studies	18% ± 2%	Explore
lymphocyte	3 studies	21% ± 6%	Explore
brush cell	3 studies	25% ± 8%	Explore
ciliated cell	3 studies	34% ± 1%	Explore
granulocyte monocyte progenitor cell	3 studies	22% ± 4%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	42% ± 24%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
intestine	9 studies	33% ± 18%	Explore
lung	7 studies	27% ± 8%	Explore
liver	5 studies	35% ± 16%	Explore
peripheral blood	3 studies	25% ± 8%	Explore
kidney	3 studies	21% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	12121.12	226 / 226	100%	123.12	406 / 406
intestine	100%	4707.65	966 / 966	99%	73.68	524 / 527
prostate	100%	2943.47	245 / 245	99%	41.38	499 / 502
bladder	100%	2897.33	21 / 21	99%	48.97	498 / 504
stomach	100%	3275.34	359 / 359	99%	60.02	282 / 286
uterus	100%	2355.64	170 / 170	98%	31.44	450 / 459
ovary	100%	4865.91	180 / 180	98%	21.38	421 / 430
pancreas	100%	3555.02	328 / 328	98%	35.10	174 / 178
esophagus	100%	3720.72	1444 / 1445	98%	29.61	179 / 183
lung	99%	2860.51	574 / 578	98%	30.36	1132 / 1155
kidney	100%	3721.47	89 / 89	94%	24.41	849 / 901
thymus	99%	1694.85	647 / 653	95%	16.67	572 / 605
breast	100%	3156.05	458 / 459	92%	17.99	1023 / 1118
brain	86%	1095.60	2270 / 2642	99%	25.18	696 / 705
skin	100%	3855.83	1807 / 1809	84%	19.11	395 / 472
adrenal gland	100%	3324.67	258 / 258	41%	9.89	94 / 230
adipose	100%	3407.00	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	34.23	80 / 80
ureter	0%	0	0 / 0	100%	55.74	1 / 1
muscle	100%	3130.27	801 / 803	0%	0	0 / 0
blood vessel	99%	2345.84	1322 / 1335	0%	0	0 / 0
spleen	98%	1333.80	237 / 241	0%	0	0 / 0
heart	97%	2311.95	839 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	22.96	43 / 45
peripheral blood	95%	1440.27	880 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	90%	18.83	26 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0001822	Biological process	kidney development
GO_0009440	Biological process	cyanate catabolic process
GO_0000098	Biological process	sulfur amino acid catabolic process
GO_0001889	Biological process	liver development
GO_0009636	Biological process	response to toxic substance
GO_0019346	Biological process	transsulfuration
GO_0021510	Biological process	spinal cord development
GO_0070814	Biological process	hydrogen sulfide biosynthetic process
GO_0070062	Cellular component	extracellular exosome
GO_0045202	Cellular component	synapse
GO_0005759	Cellular component	mitochondrial matrix
GO_0043005	Cellular component	neuron projection
GO_0005739	Cellular component	mitochondrion
GO_0004792	Molecular function	thiosulfate sulfurtransferase activity
GO_0016784	Molecular function	3-mercaptopyruvate sulfurtransferase activity
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	MPST
Protein name	Mercaptopyruvate sulfurtransferase 3-mercaptopyruvate sulfurtransferase (MST) (EC 2.8.1.2) Mercaptopyruvate sulfurtransferase variant Truncated mercaptopyruvate sulfurtransferase variant
Synonyms	TST2
Description	FUNCTION: Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions. .
Accessions	ENST00000404802.7 [P25325-1] B1AH49 ENST00000628507.1 ENST00000404393.5 Q2VEU1 ENST00000341116.7 [P25325-1] ENST00000429360.6 [P25325-2] ENST00000401419.7 [P25325-1] ENST00000397225.2 [P25325-1] Q2VEU0 P25325

MPST report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review