CHRNA10 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CHRNA10 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CHRNA10 at tissue level.

III. Associated gene sets

GO_0010996Biological processresponse to auditory stimulus
GO_0042391Biological processregulation of membrane potential
GO_0051899Biological processmembrane depolarization
GO_0060079Biological processexcitatory postsynaptic potential
GO_0034220Biological processmonoatomic ion transmembrane transport
GO_0070373Biological processnegative regulation of ERK1 and ERK2 cascade
GO_0007204Biological processpositive regulation of cytosolic calcium ion concentration
GO_0007268Biological processchemical synaptic transmission
GO_0042127Biological processregulation of cell population proliferation
GO_0042472Biological processinner ear morphogenesis
GO_0050910Biological processdetection of mechanical stimulus involved in sensory perception of sound
GO_0007271Biological processsynaptic transmission, cholinergic
GO_0070588Biological processcalcium ion transmembrane transport
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0043204Cellular componentperikaryon
GO_1902495Cellular componenttransmembrane transporter complex
GO_0043005Cellular componentneuron projection
GO_0098981Cellular componentcholinergic synapse
GO_0045202Cellular componentsynapse
GO_0030424Cellular componentaxon
GO_0099634Cellular componentpostsynaptic specialization membrane
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0005102Molecular functionsignaling receptor binding
GO_0022848Molecular functionacetylcholine-gated monoatomic cation-selective channel activity
GO_0005262Molecular functioncalcium channel activity

IV. Literature review

[source]
Gene nameCHRNA10
Protein nameNeuronal acetylcholine receptor subunit alpha-10 (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10)
CHRNA10 protein
Cholinergic receptor nicotinic alpha 10 subunit
SynonymsNACHRA10
DescriptionFUNCTION: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. .

AccessionsENST00000250699.2
ENST00000534359.1
E9PNT7
ENST00000526599.1
E9PNX2
Q9GZZ6
C4IXS7