CADM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007283Biological processspermatogenesis
GO_0045954Biological processpositive regulation of natural killer cell mediated cytotoxicity
GO_0001913Biological processT cell mediated cytotoxicity
GO_0001889Biological processliver development
GO_0120154Biological processnegative regulation of ERBB4 signaling pathway
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0007156Biological processhomophilic cell adhesion via plasma membrane adhesion molecules
GO_0030154Biological processcell differentiation
GO_0008037Biological processcell recognition
GO_0051606Biological processdetection of stimulus
GO_0050798Biological processactivated T cell proliferation
GO_0006915Biological processapoptotic process
GO_0001819Biological processpositive regulation of cytokine production
GO_0042271Biological processsusceptibility to natural killer cell mediated cytotoxicity
GO_0007157Biological processheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO_0005886Cellular componentplasma membrane
GO_0043005Cellular componentneuron projection
GO_0030425Cellular componentdendrite
GO_0005911Cellular componentcell-cell junction
GO_0045202Cellular componentsynapse
GO_0014069Cellular componentpostsynaptic density
GO_0016323Cellular componentbasolateral plasma membrane
GO_0042803Molecular functionprotein homodimerization activity
GO_0005102Molecular functionsignaling receptor binding
GO_0030165Molecular functionPDZ domain binding
GO_0050839Molecular functioncell adhesion molecule binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCADM1
Protein nameCell adhesion molecule 1 isoform B
Cell adhesion molecule 1 isoform A
Cell adhesion molecule 1
Truncated CADM1 protein
CADM1 protein
Cell adhesion molecule 1 (Immunoglobulin superfamily member 4) (IgSF4) (Nectin-like protein 2) (NECL-2) (Spermatogenic immunoglobulin superfamily) (SgIgSF) (Synaptic cell adhesion molecule) (SynCAM) (Tumor suppressor in lung cancer 1) (TSLC-1)
Cell adhesion molecule 1 isoform D
SynonymsSYNCAM
NECL2
IGSF4
TSLC1
IGSF4A
DescriptionFUNCTION: Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner . Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner (By similarity). Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo . In mast cells, may mediate attachment to and promote communication with nerves . CADM1, together with MITF, is essential for development and survival of mast cells in vivo . By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node (By similarity). Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity). Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity). Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons (By similarity). May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa (By similarity). Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells . May contribute to the less invasive phenotypes of lepidic growth tumor cells . .

AccessionsQ9BY67
ENST00000612235.4
H1ZZW6
H0YG94
H1ZZW4
ENST00000540951.1
ENST00000543540.5
ENST00000543249.1
H1ZZW5
ENST00000452722.7 [Q9BY67-1]
X5DNF2
ENST00000542450.5
F5H372
ENST00000537058.5 [Q9BY67-4]
X5DQS5
X5D8W0
ENST00000331581.11 [Q9BY67-3]
ENST00000545094.5
X5DQR8
A0A0A0MTJ8
ENST00000542447.6 [Q9BY67-5]
X5D7A8
ENST00000536727.5
H1ZZW3
F5H125
F5H0H5
A0A087X0T8
F5H8J9
A0A4Z1
ENST00000545380.5