Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 22 studies | 69% ± 21% | |
oligodendrocyte precursor cell | 17 studies | 66% ± 19% | |
oligodendrocyte | 16 studies | 64% ± 15% | |
glutamatergic neuron | 13 studies | 67% ± 20% | |
type I pneumocyte | 12 studies | 70% ± 18% | |
type II pneumocyte | 11 studies | 54% ± 18% | |
GABAergic neuron | 11 studies | 64% ± 19% | |
pericyte | 10 studies | 50% ± 19% | |
neuron | 10 studies | 64% ± 19% | |
retinal rod cell | 9 studies | 80% ± 20% | |
retinal cone cell | 8 studies | 71% ± 18% | |
retinal ganglion cell | 8 studies | 56% ± 25% | |
epithelial cell | 8 studies | 44% ± 17% | |
fibroblast | 8 studies | 32% ± 26% | |
endothelial cell | 7 studies | 47% ± 16% | |
amacrine cell | 7 studies | 39% ± 24% | |
interneuron | 7 studies | 58% ± 21% | |
ciliated cell | 7 studies | 27% ± 13% | |
macrophage | 6 studies | 38% ± 27% | |
glial cell | 6 studies | 42% ± 17% | |
microglial cell | 6 studies | 41% ± 18% | |
basal cell | 6 studies | 42% ± 27% | |
Mueller cell | 6 studies | 83% ± 12% | |
conventional dendritic cell | 6 studies | 35% ± 28% | |
kidney distal convoluted tubule epithelial cell | 5 studies | 46% ± 8% | |
retinal bipolar neuron | 5 studies | 85% ± 11% | |
OFF-bipolar cell | 5 studies | 68% ± 26% | |
ON-bipolar cell | 5 studies | 76% ± 23% | |
Schwann cell | 5 studies | 65% ± 19% | |
adipocyte | 5 studies | 20% ± 4% | |
cardiac muscle cell | 5 studies | 44% ± 5% | |
club cell | 5 studies | 35% ± 5% | |
connective tissue cell | 4 studies | 41% ± 22% | |
abnormal cell | 4 studies | 38% ± 15% | |
granule cell | 4 studies | 74% ± 20% | |
myofibroblast cell | 4 studies | 25% ± 7% | |
plasma cell | 4 studies | 42% ± 29% | |
mucus secreting cell | 4 studies | 33% ± 17% | |
pancreatic A cell | 3 studies | 34% ± 12% | |
pancreatic D cell | 3 studies | 62% ± 27% | |
type B pancreatic cell | 3 studies | 65% ± 17% | |
differentiation-committed oligodendrocyte precursor | 3 studies | 74% ± 10% | |
GABAergic interneuron | 3 studies | 64% ± 3% | |
progenitor cell | 3 studies | 51% ± 13% | |
smooth muscle cell | 3 studies | 46% ± 33% | |
GABAergic amacrine cell | 3 studies | 60% ± 10% | |
glycinergic amacrine cell | 3 studies | 49% ± 4% | |
rod bipolar cell | 3 studies | 95% ± 5% | |
CD8-positive, alpha-beta T cell | 3 studies | 37% ± 24% | |
chondrocyte | 3 studies | 46% ± 37% | |
dendritic cell | 3 studies | 52% ± 32% | |
melanocyte | 3 studies | 51% ± 34% | |
monocyte | 3 studies | 48% ± 35% | |
hepatocyte | 3 studies | 68% ± 26% | |
neural progenitor cell | 3 studies | 53% ± 25% | |
ependymal cell | 3 studies | 63% ± 12% | |
kidney loop of Henle epithelial cell | 3 studies | 25% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 6824.41 | 2636 / 2642 | 99% | 41.51 | 701 / 705 |
thymus | 100% | 6285.95 | 652 / 653 | 95% | 67.95 | 572 / 605 |
prostate | 91% | 1331.14 | 222 / 245 | 97% | 26.73 | 487 / 502 |
liver | 96% | 1597.34 | 217 / 226 | 90% | 22.11 | 366 / 406 |
adrenal gland | 95% | 2229.85 | 246 / 258 | 85% | 41.54 | 196 / 230 |
ovary | 82% | 1029.59 | 148 / 180 | 91% | 21.42 | 392 / 430 |
lung | 99% | 4887.50 | 575 / 578 | 68% | 19.74 | 791 / 1155 |
breast | 77% | 965.48 | 354 / 459 | 79% | 15.70 | 885 / 1118 |
kidney | 85% | 1289.38 | 76 / 89 | 68% | 10.55 | 615 / 901 |
pancreas | 70% | 802.55 | 228 / 328 | 65% | 8.92 | 116 / 178 |
skin | 62% | 827.04 | 1125 / 1809 | 69% | 25.42 | 328 / 472 |
bladder | 86% | 1005.52 | 18 / 21 | 27% | 6.52 | 134 / 504 |
uterus | 59% | 671.46 | 100 / 170 | 33% | 9.68 | 152 / 459 |
esophagus | 71% | 964.89 | 1028 / 1445 | 20% | 3.82 | 37 / 183 |
intestine | 74% | 1449.26 | 717 / 966 | 13% | 2.02 | 67 / 527 |
heart | 86% | 1459.39 | 738 / 861 | 0% | 0 | 0 / 0 |
stomach | 50% | 609.79 | 179 / 359 | 19% | 3.95 | 54 / 286 |
lymph node | 0% | 0 | 0 / 0 | 66% | 11.09 | 19 / 29 |
adipose | 50% | 532.26 | 604 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 23% | 4.49 | 18 / 80 |
spleen | 22% | 191.48 | 52 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 18% | 2.63 | 8 / 45 |
muscle | 17% | 261.28 | 138 / 803 | 0% | 0 | 0 / 0 |
blood vessel | 15% | 168.40 | 206 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 4% | 69.51 | 36 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0007283 | Biological process | spermatogenesis |
GO_0045954 | Biological process | positive regulation of natural killer cell mediated cytotoxicity |
GO_0001913 | Biological process | T cell mediated cytotoxicity |
GO_0001889 | Biological process | liver development |
GO_0120154 | Biological process | negative regulation of ERBB4 signaling pathway |
GO_0001933 | Biological process | negative regulation of protein phosphorylation |
GO_0007156 | Biological process | homophilic cell adhesion via plasma membrane adhesion molecules |
GO_0030154 | Biological process | cell differentiation |
GO_0008037 | Biological process | cell recognition |
GO_0051606 | Biological process | detection of stimulus |
GO_0050798 | Biological process | activated T cell proliferation |
GO_0006915 | Biological process | apoptotic process |
GO_0001819 | Biological process | positive regulation of cytokine production |
GO_0042271 | Biological process | susceptibility to natural killer cell mediated cytotoxicity |
GO_0007157 | Biological process | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules |
GO_0005886 | Cellular component | plasma membrane |
GO_0043005 | Cellular component | neuron projection |
GO_0030425 | Cellular component | dendrite |
GO_0005911 | Cellular component | cell-cell junction |
GO_0045202 | Cellular component | synapse |
GO_0014069 | Cellular component | postsynaptic density |
GO_0016323 | Cellular component | basolateral plasma membrane |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0005102 | Molecular function | signaling receptor binding |
GO_0030165 | Molecular function | PDZ domain binding |
GO_0050839 | Molecular function | cell adhesion molecule binding |
GO_0005515 | Molecular function | protein binding |
Gene name | CADM1 |
Protein name | Cell adhesion molecule 1 isoform B Cell adhesion molecule 1 isoform A Cell adhesion molecule 1 Truncated CADM1 protein CADM1 protein Cell adhesion molecule 1 (Immunoglobulin superfamily member 4) (IgSF4) (Nectin-like protein 2) (NECL-2) (Spermatogenic immunoglobulin superfamily) (SgIgSF) (Synaptic cell adhesion molecule) (SynCAM) (Tumor suppressor in lung cancer 1) (TSLC-1) Cell adhesion molecule 1 isoform D |
Synonyms | SYNCAM NECL2 IGSF4 TSLC1 IGSF4A |
Description | FUNCTION: Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner . Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner (By similarity). Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo . In mast cells, may mediate attachment to and promote communication with nerves . CADM1, together with MITF, is essential for development and survival of mast cells in vivo . By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node (By similarity). Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity). Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity). Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons (By similarity). May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa (By similarity). Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells . May contribute to the less invasive phenotypes of lepidic growth tumor cells . . |
Accessions | Q9BY67 ENST00000612235.4 H1ZZW6 H0YG94 H1ZZW4 ENST00000540951.1 ENST00000543540.5 ENST00000543249.1 H1ZZW5 ENST00000452722.7 [Q9BY67-1] X5DNF2 ENST00000542450.5 F5H372 ENST00000537058.5 [Q9BY67-4] X5DQS5 X5D8W0 ENST00000331581.11 [Q9BY67-3] ENST00000545094.5 X5DQR8 A0A0A0MTJ8 ENST00000542447.6 [Q9BY67-5] X5D7A8 ENST00000536727.5 H1ZZW3 F5H125 F5H0H5 A0A087X0T8 F5H8J9 A0A4Z1 ENST00000545380.5 |