T cell mediated cytotoxicity

I. Involved cell-cell interactions

[source]
Interactors
Protein name
Directionality
Classification
1CRTAM-CADM1CRTAM_HUMAN - CADM1_HUMANAdhesion-Adhesion

II. Literature review

[source]
NameT cell mediated cytotoxicity
IDGO_0001913
collection_id

Biological process

Exact synonym

T cell mediated apoptosis, T cell mediated cell death, T cell mediated cell killing, T lymphocyte mediated cytotoxicity, T-cell mediated apoptosis, T-cell mediated cell death, T-cell mediated cell killing, T-cell mediated cytotoxicity, T-lymphocyte mediated cytotoxicity

Description

The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.

Related synonym

T cell mediated cytolysis

Comment

Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in the induction of apoptosis in the target cell. Note that both CD4 and CD8 positive T cells can mediate apoptosis of target cells, independently of their definition as 'helper' T cells or not.

External URL
Genes