Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 7 studies | 20% ± 5% | |
capillary endothelial cell | 6 studies | 18% ± 4% | |
B cell | 5 studies | 18% ± 1% | |
CD16-positive, CD56-dim natural killer cell, human | 5 studies | 24% ± 5% | |
non-classical monocyte | 5 studies | 23% ± 9% | |
CD8-positive, alpha-beta T cell | 4 studies | 30% ± 5% | |
conventional dendritic cell | 4 studies | 22% ± 5% | |
natural killer cell | 4 studies | 26% ± 6% | |
plasmacytoid dendritic cell | 4 studies | 21% ± 4% | |
dendritic cell | 4 studies | 31% ± 15% | |
CD16-negative, CD56-bright natural killer cell, human | 3 studies | 19% ± 3% | |
effector memory CD8-positive, alpha-beta T cell | 3 studies | 20% ± 0% | |
mature NK T cell | 3 studies | 19% ± 3% | |
plasmablast | 3 studies | 22% ± 5% | |
glomerular endothelial cell | 3 studies | 20% ± 1% | |
memory B cell | 3 studies | 20% ± 3% | |
mucosal invariant T cell | 3 studies | 24% ± 4% | |
naive B cell | 3 studies | 21% ± 1% | |
epithelial cell | 3 studies | 29% ± 11% | |
CD8-positive, alpha-beta memory T cell | 3 studies | 22% ± 2% | |
gamma-delta T cell | 3 studies | 19% ± 2% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
peripheral blood | 3 studies | 20% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 3645.97 | 1444 / 1445 | 100% | 25.45 | 183 / 183 |
intestine | 100% | 3983.72 | 966 / 966 | 99% | 20.71 | 524 / 527 |
lung | 100% | 6915.15 | 578 / 578 | 99% | 21.90 | 1146 / 1155 |
stomach | 100% | 2345.07 | 358 / 359 | 99% | 19.11 | 284 / 286 |
skin | 100% | 3794.69 | 1808 / 1809 | 99% | 34.79 | 467 / 472 |
uterus | 100% | 3915.19 | 170 / 170 | 98% | 32.10 | 452 / 459 |
bladder | 100% | 2804.48 | 21 / 21 | 97% | 22.47 | 488 / 504 |
breast | 100% | 4127.03 | 459 / 459 | 96% | 17.44 | 1073 / 1118 |
brain | 97% | 1772.31 | 2561 / 2642 | 99% | 14.97 | 698 / 705 |
thymus | 100% | 3477.92 | 652 / 653 | 95% | 11.62 | 577 / 605 |
prostate | 100% | 2865.90 | 244 / 245 | 95% | 9.58 | 478 / 502 |
kidney | 100% | 3127.85 | 89 / 89 | 93% | 15.54 | 834 / 901 |
ovary | 100% | 2388.96 | 180 / 180 | 92% | 15.06 | 397 / 430 |
pancreas | 90% | 1215.90 | 296 / 328 | 98% | 19.06 | 175 / 178 |
adrenal gland | 100% | 2833.03 | 257 / 258 | 86% | 9.84 | 198 / 230 |
liver | 96% | 1596.47 | 216 / 226 | 87% | 9.93 | 354 / 406 |
adipose | 100% | 4443.65 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 51.69 | 29 / 29 |
spleen | 100% | 9497.99 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 43.51 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 5.75 | 1 / 1 |
heart | 99% | 1900.77 | 854 / 861 | 0% | 0 | 0 / 0 |
blood vessel | 99% | 2252.69 | 1319 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 98% | 6132.53 | 912 / 929 | 0% | 0 | 0 / 0 |
muscle | 88% | 1218.74 | 708 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 79% | 10.69 | 63 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0019885 | Biological process | antigen processing and presentation of endogenous peptide antigen via MHC class I |
GO_0055085 | Biological process | transmembrane transport |
GO_0002485 | Biological process | antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent |
GO_0002237 | Biological process | response to molecule of bacterial origin |
GO_0001913 | Biological process | T cell mediated cytotoxicity |
GO_0002481 | Biological process | antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent |
GO_0002489 | Biological process | antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent |
GO_0001916 | Biological process | positive regulation of T cell mediated cytotoxicity |
GO_0046968 | Biological process | peptide antigen transport |
GO_0015031 | Biological process | protein transport |
GO_0046967 | Biological process | cytosol to endoplasmic reticulum transport |
GO_0042825 | Cellular component | TAP complex |
GO_0016020 | Cellular component | membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0016607 | Cellular component | nuclear speck |
GO_0033116 | Cellular component | endoplasmic reticulum-Golgi intermediate compartment membrane |
GO_0042824 | Cellular component | MHC class I peptide loading complex |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0030670 | Cellular component | phagocytic vesicle membrane |
GO_0015433 | Molecular function | ABC-type peptide antigen transporter activity |
GO_0046980 | Molecular function | tapasin binding |
GO_0023029 | Molecular function | MHC class Ib protein binding |
GO_0046872 | Molecular function | metal ion binding |
GO_1904680 | Molecular function | peptide transmembrane transporter activity |
GO_0005524 | Molecular function | ATP binding |
GO_0015440 | Molecular function | ABC-type peptide transporter activity |
GO_0005515 | Molecular function | protein binding |
GO_0046978 | Molecular function | TAP1 binding |
GO_0016887 | Molecular function | ATP hydrolysis activity |
GO_0042605 | Molecular function | peptide antigen binding |
Gene name | TAP2 |
Protein name | Transporter 2, ATP-binding cassette, sub-family B TAP Antigen peptide transporter 2 (APT2) (EC 7.4.2.14) (ATP-binding cassette sub-family B member 3) (Peptide supply factor 2) (Peptide transporter PSF2) (PSF-2) (Peptide transporter TAP2) (Peptide transporter involved in antigen processing 2) (Really interesting new gene 11 protein) (RING11) Truncated antigen peptide transporter 2 ABC-type antigen peptide transporter (EC 7.4.2.14) Transporter 2, ATP binding cassette subfamily B member TAP2 protein |
Synonyms | ABCB3 Y1 RING11 PSF2 hCG_2001583 |
Description | FUNCTION: ABC transporter associated with antigen processing. In complex with TAP1 mediates unidirectional translocation of peptide antigens from cytosol to endoplasmic reticulum (ER) for loading onto MHC class I (MHCI) molecules . Uses the chemical energy of ATP to export peptides against the concentration gradient . During the transport cycle alternates between 'inward-facing' state with peptide binding site facing the cytosol to 'outward-facing' state with peptide binding site facing the ER lumen. Peptide antigen binding to ATP-loaded TAP1-TAP2 induces a switch to hydrolysis-competent 'outward-facing' conformation ready for peptide loading onto nascent MHCI molecules. Subsequently ATP hydrolysis resets the transporter to the 'inward facing' state for a new cycle . Typically transports intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome. Binds peptides with free N- and C-termini, the first three and the C-terminal residues being critical. Preferentially selects peptides having a highly hydrophobic residue at position 3 and hydrophobic or charged residues at the C-terminal anchor. Proline at position 2 has the most destabilizing effect . As a component of the peptide loading complex (PLC), acts as a molecular scaffold essential for peptide-MHCI assembly and antigen presentation . . |
Accessions | A0A8V8TNI0 ENST00000698441.1 B6VNV2 A0A994J4Y7 Q03519 ENST00000439425.6 [Q03519-2] Q96P38 ENST00000451907.2 [Q03519-2] A0A0G2JLV0 A0A087WYD6 ENST00000426977.2 [Q03519-2] ENST00000457634.6 ENST00000698449.1 ENST00000443713.6 [Q03519-1] ENST00000383118.8 [Q03519-1] Q9UQ60 ENST00000652259.1 [Q03519-2] Q15547 X5CMH5 ENST00000383119.8 [Q03519-2] ENST00000698440.1 [Q03519-1] ENST00000383239.8 [Q03519-1] ENST00000613095.1 ENST00000612574.1 ENST00000374897.4 [Q03519-1] ENST00000419142.6 ENST00000620674.1 ENST00000705716.1 ENST00000455842.2 Q99591 ENST00000445986.6 A0A140T9S0 ENST00000414145.6 [Q03519-2] ENST00000383240.8 [Q03519-2] ENST00000619283.1 Q9UP03 ENST00000698448.1 [Q03519-1] A0A8V8TNJ0 Q5JNW1 ENST00000452371.6 |