TAP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019885Biological processantigen processing and presentation of endogenous peptide antigen via MHC class I
GO_0055085Biological processtransmembrane transport
GO_0002485Biological processantigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
GO_0002237Biological processresponse to molecule of bacterial origin
GO_0001913Biological processT cell mediated cytotoxicity
GO_0002481Biological processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
GO_0002489Biological processantigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent
GO_0001916Biological processpositive regulation of T cell mediated cytotoxicity
GO_0046968Biological processpeptide antigen transport
GO_0015031Biological processprotein transport
GO_0046967Biological processcytosol to endoplasmic reticulum transport
GO_0042825Cellular componentTAP complex
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0016607Cellular componentnuclear speck
GO_0033116Cellular componentendoplasmic reticulum-Golgi intermediate compartment membrane
GO_0042824Cellular componentMHC class I peptide loading complex
GO_0005783Cellular componentendoplasmic reticulum
GO_0030670Cellular componentphagocytic vesicle membrane
GO_0015433Molecular functionABC-type peptide antigen transporter activity
GO_0046980Molecular functiontapasin binding
GO_0023029Molecular functionMHC class Ib protein binding
GO_0046872Molecular functionmetal ion binding
GO_1904680Molecular functionpeptide transmembrane transporter activity
GO_0005524Molecular functionATP binding
GO_0015440Molecular functionABC-type peptide transporter activity
GO_0005515Molecular functionprotein binding
GO_0046978Molecular functionTAP1 binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0042605Molecular functionpeptide antigen binding

IV. Literature review

[source]
Gene nameTAP2
Protein nameTransporter 2, ATP-binding cassette, sub-family B
TAP
Antigen peptide transporter 2 (APT2) (EC 7.4.2.14) (ATP-binding cassette sub-family B member 3) (Peptide supply factor 2) (Peptide transporter PSF2) (PSF-2) (Peptide transporter TAP2) (Peptide transporter involved in antigen processing 2) (Really interesting new gene 11 protein) (RING11)
Truncated antigen peptide transporter 2
ABC-type antigen peptide transporter (EC 7.4.2.14)
Transporter 2, ATP binding cassette subfamily B member
TAP2 protein
SynonymsABCB3
Y1
RING11
PSF2
hCG_2001583
DescriptionFUNCTION: ABC transporter associated with antigen processing. In complex with TAP1 mediates unidirectional translocation of peptide antigens from cytosol to endoplasmic reticulum (ER) for loading onto MHC class I (MHCI) molecules . Uses the chemical energy of ATP to export peptides against the concentration gradient . During the transport cycle alternates between 'inward-facing' state with peptide binding site facing the cytosol to 'outward-facing' state with peptide binding site facing the ER lumen. Peptide antigen binding to ATP-loaded TAP1-TAP2 induces a switch to hydrolysis-competent 'outward-facing' conformation ready for peptide loading onto nascent MHCI molecules. Subsequently ATP hydrolysis resets the transporter to the 'inward facing' state for a new cycle . Typically transports intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome. Binds peptides with free N- and C-termini, the first three and the C-terminal residues being critical. Preferentially selects peptides having a highly hydrophobic residue at position 3 and hydrophobic or charged residues at the C-terminal anchor. Proline at position 2 has the most destabilizing effect . As a component of the peptide loading complex (PLC), acts as a molecular scaffold essential for peptide-MHCI assembly and antigen presentation . .

AccessionsA0A8V8TNI0
ENST00000698441.1
B6VNV2
A0A994J4Y7
Q03519
ENST00000439425.6 [Q03519-2]
Q96P38
ENST00000451907.2 [Q03519-2]
A0A0G2JLV0
A0A087WYD6
ENST00000426977.2 [Q03519-2]
ENST00000457634.6
ENST00000698449.1
ENST00000443713.6 [Q03519-1]
ENST00000383118.8 [Q03519-1]
Q9UQ60
ENST00000652259.1 [Q03519-2]
Q15547
X5CMH5
ENST00000383119.8 [Q03519-2]
ENST00000698440.1 [Q03519-1]
ENST00000383239.8 [Q03519-1]
ENST00000613095.1
ENST00000612574.1
ENST00000374897.4 [Q03519-1]
ENST00000419142.6
ENST00000620674.1
ENST00000705716.1
ENST00000455842.2
Q99591
ENST00000445986.6
A0A140T9S0
ENST00000414145.6 [Q03519-2]
ENST00000383240.8 [Q03519-2]
ENST00000619283.1
Q9UP03
ENST00000698448.1 [Q03519-1]
A0A8V8TNJ0
Q5JNW1
ENST00000452371.6