Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 16 studies | 30% ± 11% | |
| glutamatergic neuron | 11 studies | 54% ± 23% | |
| oligodendrocyte precursor cell | 11 studies | 34% ± 17% | |
| fibroblast | 11 studies | 25% ± 8% | |
| astrocyte | 11 studies | 35% ± 13% | |
| oligodendrocyte | 11 studies | 24% ± 9% | |
| GABAergic neuron | 10 studies | 45% ± 24% | |
| microglial cell | 10 studies | 27% ± 8% | |
| adipocyte | 9 studies | 28% ± 9% | |
| neuron | 7 studies | 35% ± 13% | |
| pericyte | 7 studies | 23% ± 7% | |
| smooth muscle cell | 7 studies | 25% ± 7% | |
| interneuron | 6 studies | 49% ± 24% | |
| macrophage | 6 studies | 31% ± 5% | |
| retinal ganglion cell | 6 studies | 42% ± 22% | |
| epithelial cell | 6 studies | 31% ± 10% | |
| retina horizontal cell | 6 studies | 22% ± 5% | |
| amacrine cell | 5 studies | 28% ± 6% | |
| retinal cone cell | 5 studies | 21% ± 4% | |
| mast cell | 5 studies | 22% ± 5% | |
| endothelial cell of lymphatic vessel | 5 studies | 26% ± 4% | |
| granule cell | 4 studies | 31% ± 9% | |
| myeloid cell | 4 studies | 23% ± 4% | |
| retinal bipolar neuron | 4 studies | 20% ± 2% | |
| cardiac muscle cell | 4 studies | 26% ± 1% | |
| ciliated cell | 4 studies | 23% ± 4% | |
| lymphocyte | 4 studies | 27% ± 8% | |
| OFF-bipolar cell | 4 studies | 22% ± 5% | |
| ON-bipolar cell | 4 studies | 24% ± 6% | |
| retinal rod cell | 4 studies | 21% ± 5% | |
| T cell | 4 studies | 21% ± 4% | |
| monocyte | 4 studies | 22% ± 2% | |
| GABAergic interneuron | 3 studies | 34% ± 3% | |
| glial cell | 3 studies | 20% ± 1% | |
| dendritic cell | 3 studies | 20% ± 4% | |
| GABAergic amacrine cell | 3 studies | 29% ± 7% | |
| Mueller cell | 3 studies | 19% ± 4% | |
| glycinergic amacrine cell | 3 studies | 23% ± 2% | |
| rod bipolar cell | 3 studies | 28% ± 6% | |
| muscle cell | 3 studies | 36% ± 16% | |
| neural progenitor cell | 3 studies | 24% ± 5% | |
| connective tissue cell | 3 studies | 19% ± 1% | |
| ependymal cell | 3 studies | 35% ± 8% | |
| myofibroblast cell | 3 studies | 23% ± 4% | |
| B cell | 3 studies | 21% ± 5% | |
| alveolar macrophage | 3 studies | 21% ± 8% | |
| type I pneumocyte | 3 studies | 21% ± 5% | |
| basal cell | 3 studies | 31% ± 16% | |
| goblet cell | 3 studies | 23% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 4061.23 | 459 / 459 | 100% | 47.56 | 1118 / 1118 |
| esophagus | 100% | 4500.75 | 1445 / 1445 | 100% | 29.44 | 183 / 183 |
| stomach | 100% | 3026.02 | 358 / 359 | 100% | 25.22 | 286 / 286 |
| prostate | 100% | 4062.85 | 244 / 245 | 100% | 41.88 | 502 / 502 |
| ovary | 100% | 4761.33 | 180 / 180 | 100% | 26.37 | 428 / 430 |
| thymus | 100% | 2912.13 | 651 / 653 | 100% | 40.62 | 604 / 605 |
| uterus | 100% | 5450.06 | 170 / 170 | 99% | 31.45 | 456 / 459 |
| intestine | 100% | 4862.73 | 966 / 966 | 99% | 24.92 | 523 / 527 |
| bladder | 100% | 5275.76 | 21 / 21 | 99% | 28.19 | 500 / 504 |
| lung | 99% | 3005.07 | 573 / 578 | 100% | 31.85 | 1155 / 1155 |
| adrenal gland | 100% | 3878.91 | 258 / 258 | 99% | 50.42 | 228 / 230 |
| brain | 99% | 7485.56 | 2619 / 2642 | 100% | 52.29 | 705 / 705 |
| kidney | 100% | 2450.40 | 89 / 89 | 99% | 25.98 | 892 / 901 |
| skin | 100% | 3423.71 | 1805 / 1809 | 97% | 26.43 | 458 / 472 |
| pancreas | 96% | 1821.47 | 314 / 328 | 99% | 32.68 | 177 / 178 |
| liver | 77% | 987.31 | 174 / 226 | 96% | 16.16 | 391 / 406 |
| adipose | 100% | 4538.20 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 5699.96 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 36.08 | 29 / 29 |
| muscle | 100% | 12131.17 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 3102.53 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 28.79 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 15.44 | 1 / 1 |
| heart | 96% | 3246.69 | 826 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 95% | 19.99 | 76 / 80 |
| peripheral blood | 73% | 1954.76 | 679 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0043029 | Biological process | T cell homeostasis |
| GO_0050796 | Biological process | regulation of insulin secretion |
| GO_0006470 | Biological process | protein dephosphorylation |
| GO_1900242 | Biological process | regulation of synaptic vesicle endocytosis |
| GO_0042098 | Biological process | T cell proliferation |
| GO_0007507 | Biological process | heart development |
| GO_0007612 | Biological process | learning |
| GO_0034097 | Biological process | response to cytokine |
| GO_0048741 | Biological process | skeletal muscle fiber development |
| GO_0007165 | Biological process | signal transduction |
| GO_0017156 | Biological process | calcium-ion regulated exocytosis |
| GO_0070886 | Biological process | positive regulation of calcineurin-NFAT signaling cascade |
| GO_0001913 | Biological process | T cell mediated cytotoxicity |
| GO_0033173 | Biological process | calcineurin-NFAT signaling cascade |
| GO_0001946 | Biological process | lymphangiogenesis |
| GO_0001915 | Biological process | negative regulation of T cell mediated cytotoxicity |
| GO_0023057 | Biological process | negative regulation of signaling |
| GO_0035774 | Biological process | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| GO_0030217 | Biological process | T cell differentiation |
| GO_0048167 | Biological process | regulation of synaptic plasticity |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0031987 | Biological process | locomotion involved in locomotory behavior |
| GO_1905673 | Biological process | positive regulation of lysosome organization |
| GO_0016311 | Biological process | dephosphorylation |
| GO_1900182 | Biological process | positive regulation of protein localization to nucleus |
| GO_0048675 | Biological process | axon extension |
| GO_0007613 | Biological process | memory |
| GO_1905665 | Biological process | positive regulation of calcium ion import across plasma membrane |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0097720 | Biological process | calcineurin-mediated signaling |
| GO_1905949 | Biological process | negative regulation of calcium ion import across plasma membrane |
| GO_0042110 | Biological process | T cell activation |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0030018 | Cellular component | Z disc |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005955 | Cellular component | calcineurin complex |
| GO_0030315 | Cellular component | T-tubule |
| GO_0005829 | Cellular component | cytosol |
| GO_0008287 | Cellular component | protein serine/threonine phosphatase complex |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0019899 | Molecular function | enzyme binding |
| GO_0017018 | Molecular function | myosin phosphatase activity |
| GO_0004722 | Molecular function | protein serine/threonine phosphatase activity |
| GO_0033192 | Molecular function | calmodulin-dependent protein phosphatase activity |
| GO_0005516 | Molecular function | calmodulin binding |
| GO_0005509 | Molecular function | calcium ion binding |
| GO_0046983 | Molecular function | protein dimerization activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0030346 | Molecular function | protein phosphatase 2B binding |
| Gene name | PPP3CB |
| Protein name | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit beta isoform) (CNA beta) Protein phosphatase 3 catalytic subunit beta Serine/threonine-protein phosphatase (EC 3.1.3.16) |
| Synonyms | CNA2 CALNB hCG_18332 CALNA2 |
| Description | FUNCTION: Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals . Dephosphorylates TFEB in response to lysosomal Ca(2+) release, resulting in TFEB nuclear translocation and stimulation of lysosomal biogenesis . Dephosphorylates and activates transcription factor NFATC1 . Dephosphorylates and inactivates transcription factor ELK1 . Dephosphorylates DARPP32 . Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). May play a role in skeletal muscle fiber type specification (By similarity). . |
| Accessions | ENST00000342558.3 ENST00000430762.6 ENST00000394829.6 [P16298-4] ENST00000394828.6 [P16298-3] Q5F2G0 ENST00000360663.10 [P16298-1] Q5F2F8 P16298 |