PPP3CB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043029Biological processT cell homeostasis
GO_0050796Biological processregulation of insulin secretion
GO_0006470Biological processprotein dephosphorylation
GO_1900242Biological processregulation of synaptic vesicle endocytosis
GO_0042098Biological processT cell proliferation
GO_0007507Biological processheart development
GO_0007612Biological processlearning
GO_0034097Biological processresponse to cytokine
GO_0048741Biological processskeletal muscle fiber development
GO_0007165Biological processsignal transduction
GO_0017156Biological processcalcium-ion regulated exocytosis
GO_0070886Biological processpositive regulation of calcineurin-NFAT signaling cascade
GO_0001913Biological processT cell mediated cytotoxicity
GO_0033173Biological processcalcineurin-NFAT signaling cascade
GO_0001946Biological processlymphangiogenesis
GO_0001915Biological processnegative regulation of T cell mediated cytotoxicity
GO_0023057Biological processnegative regulation of signaling
GO_0035774Biological processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
GO_0030217Biological processT cell differentiation
GO_0048167Biological processregulation of synaptic plasticity
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0031987Biological processlocomotion involved in locomotory behavior
GO_1905673Biological processpositive regulation of lysosome organization
GO_0016311Biological processdephosphorylation
GO_1900182Biological processpositive regulation of protein localization to nucleus
GO_0048675Biological processaxon extension
GO_0007613Biological processmemory
GO_1905665Biological processpositive regulation of calcium ion import across plasma membrane
GO_0006468Biological processprotein phosphorylation
GO_0097720Biological processcalcineurin-mediated signaling
GO_1905949Biological processnegative regulation of calcium ion import across plasma membrane
GO_0042110Biological processT cell activation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0098978Cellular componentglutamatergic synapse
GO_0005886Cellular componentplasma membrane
GO_0030018Cellular componentZ disc
GO_0005654Cellular componentnucleoplasm
GO_0005955Cellular componentcalcineurin complex
GO_0030315Cellular componentT-tubule
GO_0005829Cellular componentcytosol
GO_0008287Cellular componentprotein serine/threonine phosphatase complex
GO_0005737Cellular componentcytoplasm
GO_0019899Molecular functionenzyme binding
GO_0017018Molecular functionmyosin phosphatase activity
GO_0004722Molecular functionprotein serine/threonine phosphatase activity
GO_0033192Molecular functioncalmodulin-dependent protein phosphatase activity
GO_0005516Molecular functioncalmodulin binding
GO_0005509Molecular functioncalcium ion binding
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding
GO_0030346Molecular functionprotein phosphatase 2B binding

IV. Literature review

[source]
Gene namePPP3CB
Protein nameSerine/threonine-protein phosphatase 2B catalytic subunit beta isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit beta isoform) (CNA beta)
Protein phosphatase 3 catalytic subunit beta
Serine/threonine-protein phosphatase (EC 3.1.3.16)
SynonymsCNA2
CALNB
hCG_18332
CALNA2
DescriptionFUNCTION: Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals . Dephosphorylates TFEB in response to lysosomal Ca(2+) release, resulting in TFEB nuclear translocation and stimulation of lysosomal biogenesis . Dephosphorylates and activates transcription factor NFATC1 . Dephosphorylates and inactivates transcription factor ELK1 . Dephosphorylates DARPP32 . Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). May play a role in skeletal muscle fiber type specification (By similarity). .

AccessionsENST00000342558.3
ENST00000430762.6
ENST00000394829.6 [P16298-4]
ENST00000394828.6 [P16298-3]
Q5F2G0
ENST00000360663.10 [P16298-1]
Q5F2F8
P16298