CTSC | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	48 studies	57% ± 22%	Explore
natural killer cell	41 studies	49% ± 16%	Explore
CD8-positive, alpha-beta T cell	34 studies	40% ± 17%	Explore
fibroblast	30 studies	41% ± 21%	Explore
T cell	28 studies	30% ± 11%	Explore
regulatory T cell	26 studies	44% ± 18%	Explore
conventional dendritic cell	25 studies	43% ± 13%	Explore
non-classical monocyte	24 studies	63% ± 16%	Explore
plasmacytoid dendritic cell	23 studies	68% ± 16%	Explore
classical monocyte	23 studies	36% ± 14%	Explore
monocyte	22 studies	43% ± 19%	Explore
CD4-positive, alpha-beta T cell	22 studies	32% ± 16%	Explore
dendritic cell	21 studies	47% ± 21%	Explore
mature NK T cell	20 studies	43% ± 12%	Explore
endothelial cell	20 studies	34% ± 14%	Explore
pericyte	20 studies	31% ± 15%	Explore
gamma-delta T cell	17 studies	39% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	17 studies	53% ± 15%	Explore
myeloid cell	17 studies	41% ± 24%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	45% ± 15%	Explore
mucosal invariant T cell	14 studies	33% ± 12%	Explore
epithelial cell	13 studies	30% ± 13%	Explore
connective tissue cell	13 studies	44% ± 17%	Explore
microglial cell	12 studies	36% ± 15%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	39% ± 15%	Explore
basal cell	11 studies	36% ± 15%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	35% ± 20%	Explore
leukocyte	10 studies	37% ± 14%	Explore
smooth muscle cell	10 studies	27% ± 7%	Explore
plasma cell	9 studies	26% ± 12%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	29% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	37% ± 13%	Explore
myofibroblast cell	9 studies	28% ± 9%	Explore
vein endothelial cell	9 studies	24% ± 7%	Explore
endothelial cell of vascular tree	9 studies	23% ± 6%	Explore
alveolar macrophage	8 studies	72% ± 20%	Explore
club cell	8 studies	53% ± 22%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	58% ± 24%	Explore
mast cell	7 studies	31% ± 23%	Explore
neutrophil	7 studies	28% ± 21%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	7 studies	19% ± 4%	Explore
epithelial cell of proximal tubule	7 studies	21% ± 6%	Explore
innate lymphoid cell	7 studies	34% ± 13%	Explore
T follicular helper cell	7 studies	22% ± 6%	Explore
hematopoietic precursor cell	6 studies	42% ± 18%	Explore
plasmablast	6 studies	36% ± 22%	Explore
respiratory goblet cell	6 studies	51% ± 21%	Explore
secretory cell	6 studies	48% ± 19%	Explore
mononuclear phagocyte	6 studies	49% ± 21%	Explore
progenitor cell	6 studies	37% ± 21%	Explore
B cell	6 studies	21% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	46% ± 17%	Explore
exhausted T cell	5 studies	61% ± 11%	Explore
hematopoietic stem cell	5 studies	31% ± 21%	Explore
ciliated cell	5 studies	29% ± 16%	Explore
type II pneumocyte	5 studies	25% ± 8%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	52% ± 22%	Explore
kidney loop of Henle epithelial cell	4 studies	31% ± 8%	Explore
lymphocyte	4 studies	34% ± 15%	Explore
adventitial cell	4 studies	26% ± 6%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	63% ± 15%	Explore
intermediate monocyte	4 studies	61% ± 8%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	44% ± 26%	Explore
T-helper 17 cell	4 studies	39% ± 22%	Explore
duct epithelial cell	3 studies	29% ± 10%	Explore
capillary endothelial cell	3 studies	20% ± 2%	Explore
placental villous trophoblast	3 studies	61% ± 26%	Explore
common myeloid progenitor	3 studies	35% ± 11%	Explore
megakaryocyte	3 studies	32% ± 9%	Explore
brush cell	3 studies	36% ± 11%	Explore
tissue-resident macrophage	3 studies	64% ± 19%	Explore
intraepithelial lymphocyte	3 studies	34% ± 9%	Explore
inflammatory macrophage	3 studies	44% ± 27%	Explore
granulocyte monocyte progenitor cell	3 studies	62% ± 20%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	56% ± 25%	Explore
CD4-positive helper T cell	3 studies	21% ± 6%	Explore
glial cell	3 studies	28% ± 9%	Explore
group 3 innate lymphoid cell	3 studies	34% ± 15%	Explore
T-helper 1 cell	3 studies	47% ± 27%	Explore
double negative thymocyte	3 studies	47% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	35% ± 10%	Explore
peripheral blood	18 studies	30% ± 8%	Explore
intestine	10 studies	26% ± 11%	Explore
kidney	9 studies	30% ± 11%	Explore
liver	6 studies	28% ± 9%	Explore
placenta	4 studies	42% ± 20%	Explore
bone marrow	4 studies	33% ± 18%	Explore
brain	4 studies	31% ± 17%	Explore
uterus	3 studies	41% ± 16%	Explore
adipose	3 studies	23% ± 5%	Explore
lymph node	3 studies	31% ± 11%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	11650.07	578 / 578	100%	45.76	1150 / 1155
kidney	100%	5912.10	89 / 89	97%	52.56	874 / 901
intestine	98%	4556.17	950 / 966	98%	21.62	516 / 527
thymus	100%	3751.47	652 / 653	93%	36.83	563 / 605
stomach	93%	2173.12	335 / 359	99%	23.66	283 / 286
uterus	98%	2468.35	166 / 170	93%	27.66	429 / 459
bladder	95%	4212.76	20 / 21	94%	31.70	474 / 504
esophagus	88%	2541.48	1277 / 1445	99%	34.30	181 / 183
pancreas	88%	1716.84	287 / 328	94%	26.74	167 / 178
skin	88%	7266.85	1596 / 1809	92%	22.66	436 / 472
breast	100%	4310.10	458 / 459	80%	13.74	899 / 1118
ovary	73%	1389.24	132 / 180	88%	14.11	379 / 430
adrenal gland	97%	3628.14	250 / 258	38%	6.67	87 / 230
liver	55%	1038.00	124 / 226	55%	11.95	222 / 406
adipose	100%	7216.19	1204 / 1204	0%	0	0 / 0
spleen	100%	12391.38	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	30.85	45 / 45
ureter	0%	0	0 / 0	100%	6.51	1 / 1
peripheral blood	99%	9111.72	923 / 929	0%	0	0 / 0
prostate	80%	1764.73	197 / 245	18%	1.49	91 / 502
lymph node	0%	0	0 / 0	97%	44.04	28 / 29
blood vessel	78%	2784.37	1046 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	71%	9.32	57 / 80
brain	18%	324.84	488 / 2642	40%	6.04	283 / 705
heart	55%	1483.49	476 / 861	0%	0	0 / 0
muscle	18%	243.77	142 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1903980	Biological process	positive regulation of microglial cell activation
GO_0031642	Biological process	negative regulation of myelination
GO_0001913	Biological process	T cell mediated cytotoxicity
GO_1903052	Biological process	positive regulation of proteolysis involved in protein catabolic process
GO_0006955	Biological process	immune response
GO_0006508	Biological process	proteolysis
GO_0006915	Biological process	apoptotic process
GO_0051603	Biological process	proteolysis involved in protein catabolic process
GO_2001235	Biological process	positive regulation of apoptotic signaling pathway
GO_0035578	Cellular component	azurophil granule lumen
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0016020	Cellular component	membrane
GO_0005813	Cellular component	centrosome
GO_0005764	Cellular component	lysosome
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_0033116	Cellular component	endoplasmic reticulum-Golgi intermediate compartment membrane
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0030134	Cellular component	COPII-coated ER to Golgi transport vesicle
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0008239	Molecular function	dipeptidyl-peptidase activity
GO_0016505	Molecular function	peptidase activator activity involved in apoptotic process
GO_0031404	Molecular function	chloride ion binding
GO_0042802	Molecular function	identical protein binding
GO_0051087	Molecular function	protein-folding chaperone binding
GO_0019902	Molecular function	phosphatase binding
GO_0008234	Molecular function	cysteine-type peptidase activity
GO_0004197	Molecular function	cysteine-type endopeptidase activity
GO_0005515	Molecular function	protein binding
GO_0004252	Molecular function	serine-type endopeptidase activity

IV. Literature review

[source]

Gene name	CTSC
Protein name	Dipeptidyl peptidase 1 (EC 3.4.14.1) (Cathepsin C) (Cathepsin J) (Dipeptidyl peptidase I) (DPP-I) (DPPI) (Dipeptidyl transferase) [Cleaved into: Dipeptidyl peptidase 1 exclusion domain chain (Dipeptidyl peptidase I exclusion domain chain); Dipeptidyl peptidase 1 heavy chain (Dipeptidyl peptidase I heavy chain); Dipeptidyl peptidase 1 light chain (Dipeptidyl peptidase I light chain)] Dipeptidyl peptidase 1 isoform a preproprotein Dipeptidyl peptidase 1 (EC 3.4.14.1) (Cathepsin C) (Cathepsin J) (Dipeptidyl peptidase I) (Dipeptidyl transferase) Dipeptidyl peptidase 1 isoform a preproprotein (EC 3.4.14.1) Dipeptidyl peptidase 1 (Cathepsin C) (Cathepsin J) (Dipeptidyl peptidase I) (Dipeptidyl transferase) Cathepsin C
Synonyms	CPPI
Description	FUNCTION: Thiol protease . Has dipeptidylpeptidase activity . Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids . Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate . Can act as both an exopeptidase and endopeptidase . Activates serine proteases such as elastase, cathepsin G and granzymes A and B . .
Accessions	A0A7I2V2V5 ENST00000677106.1 [P53634-2] A0A7I2V592 ENST00000677796.1 ENST00000679199.1 H0YDA2 A0A7I2V4Z3 A0A7I2YQT5 ENST00000678554.1 A0A7I2V3A2 I3V9S3 I3V9T0 ENST00000679224.1 ENST00000528020.2 P53634 A0A7I2V466 ENST00000678506.1 ENST00000529974.2 [P53634-3] ENST00000677661.1 A0A7I2V5J2 ENST00000527018.6 ENST00000524463.6 [P53634-2] A0A7I2V3A6 ENST00000679032.1 A0A7I2YQ96 ENST00000677877.1 ENST00000227266.10 [P53634-1] A0A7I2V2Q8 ENST00000678464.1 ENST00000678915.1 ENST00000677802.1 ENST00000678520.1 ENST00000676612.1 A0A7I2V5L5 A0A7I2V5C5 H0YCY8 ENST00000393301.5 ENST00000677208.1 I3V9V6 ENST00000677468.1 A0A7I2V2F3 A0A7I2V3M6 ENST00000677976.1 A0A7I2V6E3 I3V9T1 ENST00000678395.1 I3V9V3

CTSC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review