IL7R | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
T cell	37 studies	48% ± 19%	Explore
CD8-positive, alpha-beta T cell	36 studies	47% ± 19%	Explore
CD4-positive, alpha-beta T cell	35 studies	72% ± 19%	Explore
regulatory T cell	26 studies	51% ± 16%	Explore
gamma-delta T cell	20 studies	53% ± 20%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	20 studies	80% ± 13%	Explore
mucosal invariant T cell	17 studies	85% ± 11%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	71% ± 18%	Explore
mature NK T cell	15 studies	45% ± 20%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	56% ± 19%	Explore
innate lymphoid cell	13 studies	68% ± 19%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	66% ± 22%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	49% ± 21%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	38% ± 15%	Explore
dendritic cell	11 studies	48% ± 27%	Explore
macrophage	10 studies	30% ± 15%	Explore
natural killer cell	9 studies	31% ± 14%	Explore
T follicular helper cell	8 studies	56% ± 29%	Explore
effector CD4-positive, alpha-beta T cell	7 studies	54% ± 24%	Explore
CD4-positive helper T cell	6 studies	76% ± 19%	Explore
platelet	6 studies	27% ± 5%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	31% ± 10%	Explore
leukocyte	6 studies	33% ± 8%	Explore
capillary endothelial cell	6 studies	39% ± 17%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	80% ± 25%	Explore
CD4-positive, alpha-beta cytotoxic T cell	5 studies	41% ± 14%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	68% ± 27%	Explore
group 3 innate lymphoid cell	5 studies	90% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	42% ± 19%	Explore
alveolar macrophage	4 studies	23% ± 6%	Explore
monocyte	4 studies	20% ± 6%	Explore
T-helper 17 cell	4 studies	86% ± 13%	Explore
pro-B cell	4 studies	29% ± 4%	Explore
lymphocyte	4 studies	35% ± 11%	Explore
conventional dendritic cell	4 studies	29% ± 9%	Explore
double negative thymocyte	4 studies	59% ± 14%	Explore
endothelial cell	3 studies	32% ± 13%	Explore
plasmablast	3 studies	39% ± 4%	Explore
erythrocyte	3 studies	40% ± 10%	Explore
thymocyte	3 studies	54% ± 20%	Explore
myeloid cell	3 studies	20% ± 3%	Explore
vein endothelial cell	3 studies	26% ± 10%	Explore
monocyte-derived dendritic cell	3 studies	54% ± 20%	Explore
T-helper 1 cell	3 studies	79% ± 17%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	94% ± 3%	Explore
double-positive, alpha-beta thymocyte	3 studies	76% ± 15%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	21 studies	36% ± 9%	Explore
lung	7 studies	28% ± 3%	Explore
lymph node	4 studies	45% ± 17%	Explore
bone marrow	3 studies	20% ± 4%	Explore
intestine	3 studies	34% ± 14%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	12543.63	577 / 578	92%	29.33	1058 / 1155
stomach	77%	1276.72	276 / 359	79%	13.17	227 / 286
intestine	62%	3354.10	595 / 966	74%	13.08	391 / 527
breast	60%	687.19	276 / 459	73%	16.30	812 / 1118
thymus	83%	1396.04	540 / 653	50%	21.98	302 / 605
bladder	62%	1443.95	13 / 21	64%	11.94	321 / 504
esophagus	38%	418.28	555 / 1445	86%	19.27	157 / 183
prostate	64%	879.31	156 / 245	59%	8.58	296 / 502
kidney	37%	698.72	33 / 89	67%	12.21	606 / 901
spleen	100%	8098.39	241 / 241	0%	0	0 / 0
adrenal gland	69%	941.90	179 / 258	30%	6.58	70 / 230
pancreas	18%	115.56	58 / 328	81%	22.41	144 / 178
skin	49%	1854.19	884 / 1809	46%	9.59	216 / 472
uterus	32%	267.84	55 / 170	57%	8.49	261 / 459
tonsil	0%	0	0 / 0	89%	24.57	40 / 45
adipose	86%	1206.13	1040 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	83%	30.34	24 / 29
peripheral blood	81%	4657.33	751 / 929	0%	0	0 / 0
liver	30%	222.29	67 / 226	33%	4.58	132 / 406
ovary	16%	145.07	28 / 180	33%	3.25	143 / 430
blood vessel	29%	393.67	393 / 1335	0%	0	0 / 0
brain	1%	4.20	20 / 2642	10%	1.18	74 / 705
heart	10%	95.07	87 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	1%	0.07	1 / 80
muscle	0%	7.34	4 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0043029	Biological process	T cell homeostasis
GO_0019221	Biological process	cytokine-mediated signaling pathway
GO_1904894	Biological process	positive regulation of receptor signaling pathway via STAT
GO_0070233	Biological process	negative regulation of T cell apoptotic process
GO_0030097	Biological process	hemopoiesis
GO_0048535	Biological process	lymph node development
GO_0007165	Biological process	signal transduction
GO_0010628	Biological process	positive regulation of gene expression
GO_0001913	Biological process	T cell mediated cytotoxicity
GO_0001915	Biological process	negative regulation of T cell mediated cytotoxicity
GO_0001782	Biological process	B cell homeostasis
GO_0038111	Biological process	interleukin-7-mediated signaling pathway
GO_0019725	Biological process	cellular homeostasis
GO_0033077	Biological process	T cell differentiation in thymus
GO_0000018	Biological process	regulation of DNA recombination
GO_0006955	Biological process	immune response
GO_0050830	Biological process	defense response to Gram-positive bacterium
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0042100	Biological process	B cell proliferation
GO_0010467	Biological process	gene expression
GO_0000902	Biological process	cell morphogenesis
GO_0008361	Biological process	regulation of cell size
GO_0033089	Biological process	positive regulation of T cell differentiation in thymus
GO_0046427	Biological process	positive regulation of receptor signaling pathway via JAK-STAT
GO_0007166	Biological process	cell surface receptor signaling pathway
GO_0009897	Cellular component	external side of plasma membrane
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0005654	Cellular component	nucleoplasm
GO_0030669	Cellular component	clathrin-coated endocytic vesicle membrane
GO_0005829	Cellular component	cytosol
GO_0004917	Molecular function	interleukin-7 receptor activity
GO_0004896	Molecular function	cytokine receptor activity
GO_0003823	Molecular function	antigen binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	IL7R
Protein name	Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CDw127) (CD antigen CD127) Interleukin 7 receptor Interleukin-7 receptor
Synonyms
Description	FUNCTION: Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
Accessions	ENST00000508941.5 P16871 D6RG28 ENST00000505093.1 D6RDM4 ENST00000303115.8 [P16871-1] ENST00000511982.1 F6IQ79 H0YA41 D6RCR9 ENST00000506850.5 [P16871-3] B8YG18 ENST00000515665.1 F6IQ80 ENST00000514217.5

IL7R report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review