HPRT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006178Biological processguanine salvage
GO_0007625Biological processgrooming behavior
GO_0044209Biological processAMP salvage
GO_0048813Biological processdendrite morphogenesis
GO_0046038Biological processGMP catabolic process
GO_0001913Biological processT cell mediated cytotoxicity
GO_0042417Biological processdopamine metabolic process
GO_0046083Biological processadenine metabolic process
GO_0032264Biological processIMP salvage
GO_0021756Biological processstriatum development
GO_0071542Biological processdopaminergic neuron differentiation
GO_0046651Biological processlymphocyte proliferation
GO_0043103Biological processhypoxanthine salvage
GO_0006166Biological processpurine ribonucleoside salvage
GO_0032263Biological processGMP salvage
GO_0021954Biological processcentral nervous system neuron development
GO_0006164Biological processpurine nucleotide biosynthetic process
GO_0001975Biological processresponse to amphetamine
GO_0046040Biological processIMP metabolic process
GO_0046100Biological processhypoxanthine metabolic process
GO_0045964Biological processpositive regulation of dopamine metabolic process
GO_0021895Biological processcerebral cortex neuron differentiation
GO_0007626Biological processlocomotory behavior
GO_0051289Biological processprotein homotetramerization
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0042802Molecular functionidentical protein binding
GO_0000166Molecular functionnucleotide binding
GO_0000287Molecular functionmagnesium ion binding
GO_0052657Molecular functionguanine phosphoribosyltransferase activity
GO_0004422Molecular functionhypoxanthine phosphoribosyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHPRT1
Protein nameHypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8)
Hypoxanthine phosphoribosyltransferase (EC 2.4.2.8)
Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase) (EC 2.4.2.8)
SynonymsHPRT
DescriptionFUNCTION: Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.

FUNCTION: Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway. .

FUNCTION: Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway. .

AccessionsENST00000298556.8
A0A0H3YEQ7
P00492
Q6LET3
A0A140VJL3