I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| type I pneumocyte | 7 studies | 21% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| type I pneumocyte | 7 studies | 21% ± 4% |
Insufficient scRNA-seq data for expression of MICA at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 2393.19 | 653 / 653 | 100% | 19.45 | 604 / 605 |
| intestine | 100% | 2258.89 | 966 / 966 | 100% | 15.31 | 526 / 527 |
| kidney | 100% | 2149.15 | 89 / 89 | 100% | 19.98 | 897 / 901 |
| esophagus | 100% | 1965.16 | 1444 / 1445 | 99% | 13.17 | 182 / 183 |
| prostate | 100% | 2527.76 | 245 / 245 | 99% | 16.87 | 498 / 502 |
| lung | 100% | 3127.60 | 578 / 578 | 99% | 17.04 | 1139 / 1155 |
| stomach | 100% | 1357.27 | 358 / 359 | 99% | 13.38 | 282 / 286 |
| uterus | 100% | 3181.14 | 170 / 170 | 98% | 19.03 | 450 / 459 |
| skin | 100% | 1512.60 | 1801 / 1809 | 98% | 23.31 | 461 / 472 |
| breast | 100% | 2259.70 | 459 / 459 | 97% | 16.27 | 1085 / 1118 |
| ovary | 100% | 3397.17 | 180 / 180 | 96% | 11.85 | 414 / 430 |
| bladder | 100% | 2449.71 | 21 / 21 | 95% | 15.27 | 481 / 504 |
| pancreas | 97% | 888.80 | 318 / 328 | 98% | 21.13 | 175 / 178 |
| liver | 96% | 1030.80 | 218 / 226 | 97% | 11.85 | 394 / 406 |
| adrenal gland | 100% | 2321.32 | 258 / 258 | 78% | 15.59 | 179 / 230 |
| brain | 62% | 365.73 | 1649 / 2642 | 71% | 5.45 | 504 / 705 |
| adipose | 100% | 2216.27 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 2843.86 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 5.17 | 1 / 1 |
| spleen | 100% | 2140.98 | 240 / 241 | 0% | 0 | 0 / 0 |
| heart | 99% | 1284.38 | 852 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 14.96 | 44 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 7.96 | 28 / 29 |
| eye | 0% | 0 | 0 / 0 | 91% | 9.91 | 73 / 80 |
| peripheral blood | 85% | 688.81 | 790 / 929 | 0% | 0 | 0 / 0 |
| muscle | 64% | 361.10 | 517 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0009408 | Biological process | response to heat |
| GO_0002418 | Biological process | immune response to tumor cell |
| GO_0002476 | Biological process | antigen processing and presentation of endogenous peptide antigen via MHC class Ib |
| GO_0002486 | Biological process | antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent |
| GO_0046629 | Biological process | gamma-delta T cell activation |
| GO_0007165 | Biological process | signal transduction |
| GO_0051607 | Biological process | defense response to virus |
| GO_0006974 | Biological process | DNA damage response |
| GO_0001913 | Biological process | T cell mediated cytotoxicity |
| GO_0001916 | Biological process | positive regulation of T cell mediated cytotoxicity |
| GO_0042267 | Biological process | natural killer cell mediated cytotoxicity |
| GO_0006955 | Biological process | immune response |
| GO_0031640 | Biological process | killing of cells of another organism |
| GO_0045953 | Biological process | negative regulation of natural killer cell mediated cytotoxicity |
| GO_0032815 | Biological process | negative regulation of natural killer cell activation |
| GO_0042742 | Biological process | defense response to bacterium |
| GO_0005615 | Cellular component | extracellular space |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0009986 | Cellular component | cell surface |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0048018 | Molecular function | receptor ligand activity |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0046703 | Molecular function | natural killer cell lectin-like receptor binding |
| GO_0030881 | Molecular function | beta-2-microglobulin binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0042605 | Molecular function | peptide antigen binding |
| Gene name | MICA |
| Protein name | MHC class I related chain A isoform B2 MHC Class I chain-related protein (MHC class I polypeptide-related sequence A) Truncated MHC class I chain-related protein A MHC Class I chain-related protein (MHC class I polypeptide-related sequence A) (MICA) MICA protein MHC class I polypeptide-related sequence A (MIC-A) MHC Class I chain-related protein MHC class I related chain A isoform C MHC class I chain-related A antigen MHC class I polypeptide-related sequence A MHC class I polypeptide-related protein A MHC class I related chain A isoform D Major histocompatibility complex class I chain-related A Truncated major histocompatibility complex class I chain-related protein A MHC class I chain-related protein A Truncated MHC class I polypeptide-related sequence A MHC class I chain-related protein A (MHC class I polypeptide-related sequence A) (MICA) (Stress inducible class I homolog) MHC class I chain-related protein A (MHC class I polypeptide-related sequence A) Truncated MICA MHC class I related sequence A Major histocompatibility complex class I chain-related protein A MHC class I antigen MHC class I related chain A isoform B1 MHC class I-related chain A Truncated MHC class I polypeptide-related protein A MICA MHC class I related chain A isoform A |
| Synonyms | hCG_2001511 PERB11.1 |
| Description | FUNCTION: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. . |
| Accessions | A0A0M3LB79 ENST00000674131.1 A0A0M3LAT3 A0A0M3LBA3 A0A024RCL3 A0A0M3LCB6 A0A0M3LB98 A0A7D9CS82 G1JTE6 ENST00000449934.7 A0A140T9T9 C7FEB0 A0A0M3LB49 E7BBQ2 J9UPX7 Q9UDZ9 A0A0M3LB16 A0A7D9G2J0 F5CQ56 ENST00000400322.5 A0A1B0UGR8 A0A140T8Z6 A0A0M3LAV0 A0A7D9GUF1 G8FU06 A0A0M3LBB7 A0A0M3LBC6 Q9UE01 A0A0M3LBD8 ENST00000414473.6 A0A7D9C126 A0A0M3LCT1 ENST00000547609.2 [Q29983-1] A0A0M3LCN5 A0A385JFK1 ENST00000418465.5 A0A142J239 A0A385JFJ9 W5XKU5 W8RL45 M1TD20 A0A0M3LB40 Q9GJ32 A0A385JFK9 A0A0M3LB24 G3CBL6 A0A385JFK4 A0A385JFK0 Q29983 C0LZS2 F1BE19 A0A873BDV6 A0A7D9C125 A0A1W2PPN1 A0A0M3LCU6 A0A7S7RSW3 C0LZS1 D7REL5 J7IHS8 A0A7D9C115 A0A7D9C1Q4 ENST00000417943.1 F5CQ57 A0A0M3LB05 A0A140T9B8 ENST00000415525.5 A0A1V0E407 Q0EFB3 A0A0M3LB71 A0A0M3LBC0 A0A0M3LCW3 ENST00000432479.6 D4P5A5 M1PPD1 Q9GJ26 G3CBL7 Q95IC0 A0A0G2JK11 A0A0M3LC33 ENST00000420744.5 ENST00000639458.1 A0A0M3LB88 ENST00000616968.3 A0A7D9C0Y6 A0A0M3LB93 A0A7D9G2J6 A0A0M3LBC8 ENST00000616296.4 A0A023SER7 M1SWZ3 A0A0K1NXC7 A0A7D9CS89 X5GEV1 H9CTV0 B9VJ52 A0A0M3LAW3 B0FYL6 Q9UE03 A0A7S7M564 A0A1V0E430 ENST00000547767.2 A0A7D9C100 A0A7D9GVG0 A0A7D9GVE0 A0A0M3LAX7 A0A0M3LBD4 ENST00000438928.5 Q9GJ30 A0A0M3LAY5 A0A0M3LAW0 ENST00000460798.5 F5CIT6 Q9UE02 M1PIT1 A0A0M3LBD5 A0A0M3LAX6 ENST00000638993.1 F5CJX6 A0A1B0UGR6 F5CA55 F5CJX5 Q96QC4 M1NVA7 A0A0M3LB33 A0A0M3LB59 A0A516UWZ7 V5P5E0 J9TPG6 A0A5P3YYA7 ENST00000423443.5 A0A7S7RSW2 ENST00000400325.5 [Q29983-1] G9FRT9 ENST00000421350.1 W6S1K2 A0A140T9P3 A0A7D9C101 A0A7D9C121 A0A0M3LB39 F5CA56 A0A0M3LAU3 A0A0M3LC47 D6QZ32 H7BSL1 A0A7D9G6D3 A0A7D9GTW8 ENST00000546529.3 ENST00000420259.5 V5P5H4 A0A0M3LCK2 A0A7D9CS10 A0A0M3LB48 ENST00000446505.6 Q9UE00 A0A140T986 A0A5P3Z0J8 A0A0M3LAV5 A0A7D9C127 A0A0M3LC96 A0A0G2JJ55 A0A669KAV8 A0A0F6UUZ2 A0A0M3LB32 A0A0M3LBB1 A0A7D9GW21 A0A1B0UGS0 A0A0M3LC79 A0A0M3LD01 A0A140T9I5 A0A7D9G5L2 ENST00000674069.1 A0A7D9CT29 A0A0M3LCX3 A0A5B8LE57 B0FYL7 A0A0M3LBA6 A0A0M3LB25 A0A0M3LB64 ENST00000417899.5 A0A7D9G3X1 C0LU32 I3WCM9 A0A7S7M539 L7Z9L1 M1Q4R4 W6S861 F5CJX4 A0A0M3LCL8 A0A0M3LCQ0 A0A1B0UGS4 A0A5B8GVP4 A0A1W2PRA6 A0A142J2X9 G9HQC6 Q9GJ27 B0FZD0 A0A140T9Z8 A0A7D9CT54 A0A0M3LCR4 A0A0K1NWU9 A0A140T9M1 ENST00000673647.1 Q2L6G1 ENST00000436191.5 A0A669KAV5 A0A0M3LAW8 A0A2Z2H1T6 F5CIT5 A0A7D9G2H3 A0A7D9GUE3 A0A0M3LBE8 A0A0M3LCZ0 A0A0M3LB17 A0A7D9C135 H0Y615 J9YIZ8 A0A1B0Z4Z0 A0A0M3LCI5 ENST00000427477.5 Q9UDZ8 A0A0M3LC61 A0A0K1NXW1 ENST00000614103.4 A0A023SGA8 A0A1B0UGR9 C5NT78 J9YLR7 |
