EMP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1990266Biological processneutrophil migration
GO_0032060Biological processbleb assembly
GO_0060136Biological processembryonic process involved in female pregnancy
GO_0060914Biological processheart formation
GO_0072659Biological processprotein localization to plasma membrane
GO_0008283Biological processcell population proliferation
GO_0045766Biological processpositive regulation of angiogenesis
GO_0007160Biological processcell-matrix adhesion
GO_0001954Biological processpositive regulation of cell-matrix adhesion
GO_0001913Biological processT cell mediated cytotoxicity
GO_0010594Biological processregulation of endothelial cell migration
GO_2001046Biological processpositive regulation of integrin-mediated signaling pathway
GO_0007155Biological processcell adhesion
GO_0001952Biological processregulation of cell-matrix adhesion
GO_0034394Biological processprotein localization to cell surface
GO_0003093Biological processregulation of glomerular filtration
GO_0045765Biological processregulation of angiogenesis
GO_0070836Biological processcaveola assembly
GO_2001212Biological processregulation of vasculogenesis
GO_0043534Biological processblood vessel endothelial cell migration
GO_0070252Biological processactin-mediated cell contraction
GO_0032147Biological processactivation of protein kinase activity
GO_0043549Biological processregulation of kinase activity
GO_0062043Biological processpositive regulation of cardiac epithelial to mesenchymal transition
GO_0001787Biological processnatural killer cell proliferation
GO_0044854Biological processplasma membrane raft assembly
GO_0007015Biological processactin filament organization
GO_0006915Biological processapoptotic process
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0045022Biological processearly endosome to late endosome transport
GO_0016477Biological processcell migration
GO_0001765Biological processmembrane raft assembly
GO_0007566Biological processembryo implantation
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0031410Cellular componentcytoplasmic vesicle
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005794Cellular componentGolgi apparatus
GO_0005901Cellular componentcaveola
GO_0009986Cellular componentcell surface
GO_0000139Cellular componentGolgi membrane
GO_0005737Cellular componentcytoplasm
GO_0045177Cellular componentapical part of cell
GO_0005634Cellular componentnucleus
GO_0019900Molecular functionkinase binding
GO_0019901Molecular functionprotein kinase binding
GO_0005178Molecular functionintegrin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEMP2
Protein nameEpithelial membrane protein 2 (EMP-2) (Protein XMP)
SynonymsXMP
DescriptionFUNCTION: Functions as a key regulator of cell membrane composition by regulating protein surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Regulates transepithelial migration of neutrophils into the alveolar lumen, potentially via mediation of cell surface expression of adhesion markers and lipid raft formation (By similarity). Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation . Facilitates surface trafficking and formation of lipid rafts bearing GPI-anchor proteins (By similarity). Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T-cell mediated cytotoxicity (By similarity). Regulates the plasma membrane expression of the integrin heterodimers ITGA6-ITGB1, ITGA5-ITGB3 and ITGA5-ITGB1 resulting in modulation of cell-matrix adhesion . Also regulates many processes through PTK2. Regulates blood vessel endothelial cell migration and angiogenesis by regulating VEGF protein expression through PTK2 activation . Regulates cell migration and cell contraction through PTK2 and SRC activation . Regulates focal adhesion density, F-actin conformation and cell adhesion capacity through interaction with PTK2 . Positively regulates cell proliferation . Plays a role during cell death and cell blebbing . Promotes angiogenesis and vasculogenesis through induction of VEGFA via a HIF1A-dependent pathway . Also plays a role in embryo implantation by regulating surface trafficking of integrin heterodimer ITGA5-ITGB3 . Plays a role in placental angiogenesis and uterine natural killer cell regulation at the maternal-fetal placental interface, however not required in the maternal tissues for a viable pregnancy (By similarity). Involved in the early stages of embryogenic development and cardiogenesis, potentially via regulation of epithelial-mesenchymal transition timing (By similarity). May play a role in glomerular filtration (By similarity). .

AccessionsENST00000536829.1
ENST00000359543.8
P54851