Name | Number of supported studies | Average coverage | |
---|---|---|---|
fibroblast | 40 studies | 35% ± 15% | |
endothelial cell | 38 studies | 42% ± 18% | |
pericyte | 30 studies | 30% ± 13% | |
smooth muscle cell | 23 studies | 31% ± 13% | |
endothelial cell of lymphatic vessel | 21 studies | 37% ± 15% | |
basal cell | 19 studies | 34% ± 18% | |
ciliated cell | 18 studies | 43% ± 16% | |
epithelial cell | 17 studies | 41% ± 19% | |
capillary endothelial cell | 15 studies | 48% ± 20% | |
endothelial cell of vascular tree | 15 studies | 34% ± 14% | |
endothelial cell of artery | 13 studies | 50% ± 19% | |
type I pneumocyte | 12 studies | 93% ± 9% | |
type II pneumocyte | 12 studies | 51% ± 19% | |
connective tissue cell | 12 studies | 35% ± 13% | |
club cell | 11 studies | 42% ± 18% | |
myofibroblast cell | 11 studies | 34% ± 13% | |
vein endothelial cell | 11 studies | 39% ± 15% | |
secretory cell | 9 studies | 37% ± 15% | |
goblet cell | 8 studies | 30% ± 11% | |
respiratory goblet cell | 6 studies | 36% ± 23% | |
mesothelial cell | 6 studies | 47% ± 12% | |
transit amplifying cell | 6 studies | 30% ± 12% | |
abnormal cell | 5 studies | 27% ± 13% | |
mucus secreting cell | 5 studies | 23% ± 4% | |
keratinocyte | 5 studies | 49% ± 19% | |
duct epithelial cell | 4 studies | 25% ± 2% | |
squamous epithelial cell | 4 studies | 50% ± 17% | |
glomerular endothelial cell | 4 studies | 42% ± 6% | |
Schwann cell | 4 studies | 42% ± 19% | |
astrocyte | 4 studies | 28% ± 9% | |
adventitial cell | 4 studies | 31% ± 19% | |
cardiac muscle cell | 4 studies | 20% ± 3% | |
glial cell | 4 studies | 37% ± 18% | |
luminal hormone-sensing cell of mammary gland | 4 studies | 48% ± 11% | |
hepatocyte | 4 studies | 31% ± 12% | |
hillock cell | 3 studies | 37% ± 15% | |
type B pancreatic cell | 3 studies | 31% ± 15% | |
neural crest cell | 3 studies | 29% ± 4% | |
progenitor cell | 3 studies | 24% ± 6% | |
chondrocyte | 3 studies | 21% ± 4% | |
neuron | 3 studies | 29% ± 13% | |
muscle cell | 3 studies | 37% ± 16% | |
enteroendocrine cell | 3 studies | 26% ± 2% | |
oligodendrocyte precursor cell | 3 studies | 25% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 6564.60 | 459 / 459 | 99% | 96.41 | 1109 / 1118 |
lung | 100% | 31832.93 | 578 / 578 | 98% | 66.89 | 1134 / 1155 |
prostate | 100% | 5296.32 | 245 / 245 | 98% | 37.47 | 492 / 502 |
bladder | 100% | 4913.29 | 21 / 21 | 98% | 69.83 | 492 / 504 |
uterus | 100% | 4348.21 | 170 / 170 | 97% | 78.79 | 445 / 459 |
intestine | 100% | 5821.65 | 965 / 966 | 97% | 43.45 | 510 / 527 |
esophagus | 100% | 9350.07 | 1445 / 1445 | 96% | 59.04 | 176 / 183 |
ovary | 100% | 6431.86 | 180 / 180 | 95% | 45.81 | 409 / 430 |
stomach | 96% | 4150.82 | 346 / 359 | 92% | 37.19 | 264 / 286 |
liver | 96% | 3089.99 | 216 / 226 | 85% | 22.53 | 347 / 406 |
thymus | 99% | 3676.52 | 645 / 653 | 82% | 27.57 | 494 / 605 |
skin | 100% | 11666.47 | 1802 / 1809 | 74% | 21.26 | 350 / 472 |
pancreas | 29% | 526.69 | 96 / 328 | 96% | 37.31 | 171 / 178 |
tonsil | 0% | 0 | 0 / 0 | 100% | 96.55 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 46.15 | 1 / 1 |
blood vessel | 100% | 7990.20 | 1334 / 1335 | 0% | 0 | 0 / 0 |
adipose | 100% | 6065.39 | 1203 / 1204 | 0% | 0 | 0 / 0 |
heart | 100% | 4342.52 | 858 / 861 | 0% | 0 | 0 / 0 |
kidney | 46% | 935.43 | 41 / 89 | 46% | 9.82 | 410 / 901 |
spleen | 72% | 1606.09 | 174 / 241 | 0% | 0 | 0 / 0 |
adrenal gland | 28% | 520.49 | 73 / 258 | 26% | 6.36 | 59 / 230 |
brain | 30% | 569.45 | 788 / 2642 | 15% | 3.28 | 107 / 705 |
eye | 0% | 0 | 0 / 0 | 38% | 6.01 | 30 / 80 |
muscle | 27% | 493.45 | 218 / 803 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 3% | 0.45 | 1 / 29 |
peripheral blood | 0% | 2.12 | 1 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_1990266 | Biological process | neutrophil migration |
GO_0032060 | Biological process | bleb assembly |
GO_0060136 | Biological process | embryonic process involved in female pregnancy |
GO_0060914 | Biological process | heart formation |
GO_0072659 | Biological process | protein localization to plasma membrane |
GO_0008283 | Biological process | cell population proliferation |
GO_0045766 | Biological process | positive regulation of angiogenesis |
GO_0007160 | Biological process | cell-matrix adhesion |
GO_0001954 | Biological process | positive regulation of cell-matrix adhesion |
GO_0001913 | Biological process | T cell mediated cytotoxicity |
GO_0010594 | Biological process | regulation of endothelial cell migration |
GO_2001046 | Biological process | positive regulation of integrin-mediated signaling pathway |
GO_0007155 | Biological process | cell adhesion |
GO_0001952 | Biological process | regulation of cell-matrix adhesion |
GO_0034394 | Biological process | protein localization to cell surface |
GO_0003093 | Biological process | regulation of glomerular filtration |
GO_0045765 | Biological process | regulation of angiogenesis |
GO_0070836 | Biological process | caveola assembly |
GO_2001212 | Biological process | regulation of vasculogenesis |
GO_0043534 | Biological process | blood vessel endothelial cell migration |
GO_0070252 | Biological process | actin-mediated cell contraction |
GO_0032147 | Biological process | activation of protein kinase activity |
GO_0043549 | Biological process | regulation of kinase activity |
GO_0062043 | Biological process | positive regulation of cardiac epithelial to mesenchymal transition |
GO_0001787 | Biological process | natural killer cell proliferation |
GO_0044854 | Biological process | plasma membrane raft assembly |
GO_0007015 | Biological process | actin filament organization |
GO_0006915 | Biological process | apoptotic process |
GO_0008284 | Biological process | positive regulation of cell population proliferation |
GO_0045022 | Biological process | early endosome to late endosome transport |
GO_0016477 | Biological process | cell migration |
GO_0001765 | Biological process | membrane raft assembly |
GO_0007566 | Biological process | embryo implantation |
GO_0016324 | Cellular component | apical plasma membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0045121 | Cellular component | membrane raft |
GO_0031410 | Cellular component | cytoplasmic vesicle |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0016020 | Cellular component | membrane |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0005901 | Cellular component | caveola |
GO_0009986 | Cellular component | cell surface |
GO_0000139 | Cellular component | Golgi membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0045177 | Cellular component | apical part of cell |
GO_0005634 | Cellular component | nucleus |
GO_0019900 | Molecular function | kinase binding |
GO_0019901 | Molecular function | protein kinase binding |
GO_0005178 | Molecular function | integrin binding |
GO_0005515 | Molecular function | protein binding |
Gene name | EMP2 |
Protein name | Epithelial membrane protein 2 (EMP-2) (Protein XMP) |
Synonyms | XMP |
Description | FUNCTION: Functions as a key regulator of cell membrane composition by regulating protein surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Regulates transepithelial migration of neutrophils into the alveolar lumen, potentially via mediation of cell surface expression of adhesion markers and lipid raft formation (By similarity). Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation . Facilitates surface trafficking and formation of lipid rafts bearing GPI-anchor proteins (By similarity). Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T-cell mediated cytotoxicity (By similarity). Regulates the plasma membrane expression of the integrin heterodimers ITGA6-ITGB1, ITGA5-ITGB3 and ITGA5-ITGB1 resulting in modulation of cell-matrix adhesion . Also regulates many processes through PTK2. Regulates blood vessel endothelial cell migration and angiogenesis by regulating VEGF protein expression through PTK2 activation . Regulates cell migration and cell contraction through PTK2 and SRC activation . Regulates focal adhesion density, F-actin conformation and cell adhesion capacity through interaction with PTK2 . Positively regulates cell proliferation . Plays a role during cell death and cell blebbing . Promotes angiogenesis and vasculogenesis through induction of VEGFA via a HIF1A-dependent pathway . Also plays a role in embryo implantation by regulating surface trafficking of integrin heterodimer ITGA5-ITGB3 . Plays a role in placental angiogenesis and uterine natural killer cell regulation at the maternal-fetal placental interface, however not required in the maternal tissues for a viable pregnancy (By similarity). Involved in the early stages of embryogenic development and cardiogenesis, potentially via regulation of epithelial-mesenchymal transition timing (By similarity). May play a role in glomerular filtration (By similarity). . |
Accessions | ENST00000536829.1 ENST00000359543.8 P54851 |