CRTAM report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CRTAM at tissue level.

III. Associated gene sets

GO_0045580Biological processregulation of T cell differentiation
GO_0045954Biological processpositive regulation of natural killer cell mediated cytotoxicity
GO_2001185Biological processregulation of CD8-positive, alpha-beta T cell activation
GO_0001913Biological processT cell mediated cytotoxicity
GO_0001768Biological processestablishment of T cell polarity
GO_0097021Biological processlymphocyte migration into lymphoid organs
GO_0046007Biological processnegative regulation of activated T cell proliferation
GO_0008037Biological processcell recognition
GO_0050863Biological processregulation of T cell activation
GO_0051606Biological processdetection of stimulus
GO_0002355Biological processdetection of tumor cell
GO_0050798Biological processactivated T cell proliferation
GO_0002860Biological processpositive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO_0032729Biological processpositive regulation of type II interferon production
GO_0001819Biological processpositive regulation of cytokine production
GO_0007157Biological processheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO_0001772Cellular componentimmunological synapse
GO_0005886Cellular componentplasma membrane
GO_0005102Molecular functionsignaling receptor binding

IV. Literature review

[source]
Gene nameCRTAM
Protein nameCytotoxic and regulatory T-cell molecule (Class-I MHC-restricted T-cell-associated molecule) (CD antigen CD355)
Synonyms
DescriptionFUNCTION: Mediates heterophilic cell-cell adhesion which regulates the activation, differentiation and tissue retention of various T-cell subsets (By similarity). Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and IFNG/interferon-gamma secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo . Regulates CD8+ T-cell proliferation in response to T-cell receptor (TCR) activation (By similarity). Appears to be dispensable for CD8+ T-cell-mediated cytotoxicity (By similarity). Interaction with SCRIB promotes the late phase of cellular polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG, IL17 and IL22 production (By similarity). By interacting with CADM1 on CD8+ dendritic cells, regulates the retention of activated CD8+ T-cells within the draining lymph node (By similarity). Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity). Interaction with CADM1 promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity). .

AccessionsENST00000533709.1 [O95727-2]
O95727
ENST00000227348.9 [O95727-1]