PRF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051712Biological processpositive regulation of killing of cells of another organism
GO_0051260Biological processprotein homooligomerization
GO_0140507Biological processgranzyme-mediated programmed cell death signaling pathway
GO_0001771Biological processimmunological synapse formation
GO_0017038Biological processprotein import
GO_0002418Biological processimmune response to tumor cell
GO_0051607Biological processdefense response to virus
GO_0001913Biological processT cell mediated cytotoxicity
GO_0006968Biological processcellular defense response
GO_0031640Biological processkilling of cells of another organism
GO_0002357Biological processdefense response to tumor cell
GO_0006915Biological processapoptotic process
GO_0071806Biological processprotein transmembrane transport
GO_0009306Biological processprotein secretion
GO_0001772Cellular componentimmunological synapse
GO_0044194Cellular componentcytolytic granule
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_1904856Cellular componentcytolytic granule lumen
GO_0005829Cellular componentcytosol
GO_0031904Cellular componentendosome lumen
GO_0042802Molecular functionidentical protein binding
GO_0022829Molecular functionwide pore channel activity
GO_0005509Molecular functioncalcium ion binding
GO_0140911Molecular functionpore-forming activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePRF1
Protein namePerforin 1
Perforin-1 (P1) (Cytolysin) (Lymphocyte pore-forming protein) (PFP)
Perforin
SynonymsPFP
DescriptionFUNCTION: Pore-forming protein that plays a key role in granzyme-mediated programmed cell death, and in defense against virus-infected or neoplastic cells . Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease . Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores . Promotes cytolysis and apoptosis of target cells by mediating the passage and uptake of cytotoxic granzymes . Facilitates the delivery of cationic cargo protein, while anionic or neural proteins are not delivered efficiently . Perforin pores allow the release of mature caspase-7 (CASP7) into the extracellular milieu (By similarity). .

AccessionsV9TNI8
A0A1W2PR25
ENST00000638674.1
ENST00000441259.2
E6Y8C6
ENST00000373209.2
P14222