B2M report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050870Biological processpositive regulation of T cell activation
GO_0002726Biological processpositive regulation of T cell cytokine production
GO_2000774Biological processpositive regulation of cellular senescence
GO_1900122Biological processpositive regulation of receptor binding
GO_0019885Biological processantigen processing and presentation of endogenous peptide antigen via MHC class I
GO_0034756Biological processregulation of iron ion transport
GO_0007611Biological processlearning or memory
GO_0071283Biological processcellular response to iron(III) ion
GO_0032092Biological processpositive regulation of protein binding
GO_0002237Biological processresponse to molecule of bacterial origin
GO_0001913Biological processT cell mediated cytotoxicity
GO_0002481Biological processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
GO_0007608Biological processsensory perception of smell
GO_0060586Biological processmulticellular organismal-level iron ion homeostasis
GO_0006826Biological processiron ion transport
GO_0002503Biological processpeptide antigen assembly with MHC class II protein complex
GO_0050680Biological processnegative regulation of epithelial cell proliferation
GO_0001916Biological processpositive regulation of T cell mediated cytotoxicity
GO_0048260Biological processpositive regulation of receptor-mediated endocytosis
GO_0033077Biological processT cell differentiation in thymus
GO_1990000Biological processamyloid fibril formation
GO_0010977Biological processnegative regulation of neuron projection development
GO_0006879Biological processintracellular iron ion homeostasis
GO_0002502Biological processpeptide antigen assembly with MHC class I protein complex
GO_0045646Biological processregulation of erythrocyte differentiation
GO_1904434Biological processpositive regulation of ferrous iron binding
GO_0042026Biological processprotein refolding
GO_0071281Biological processcellular response to iron ion
GO_1904437Biological processpositive regulation of transferrin receptor binding
GO_0019886Biological processantigen processing and presentation of exogenous peptide antigen via MHC class II
GO_0071316Biological processcellular response to nicotine
GO_0050778Biological processpositive regulation of immune response
GO_1900121Biological processnegative regulation of receptor binding
GO_2000978Biological processnegative regulation of forebrain neuron differentiation
GO_0050768Biological processnegative regulation of neurogenesis
GO_0051289Biological processprotein homotetramerization
GO_0005615Cellular componentextracellular space
GO_0009897Cellular componentexternal side of plasma membrane
GO_0031902Cellular componentlate endosome membrane
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0035580Cellular componentspecific granule lumen
GO_0016020Cellular componentmembrane
GO_0031901Cellular componentearly endosome membrane
GO_0055038Cellular componentrecycling endosome membrane
GO_0070062Cellular componentextracellular exosome
GO_0005794Cellular componentGolgi apparatus
GO_0005925Cellular componentfocal adhesion
GO_0000139Cellular componentGolgi membrane
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0042824Cellular componentMHC class I peptide loading complex
GO_1904724Cellular componenttertiary granule lumen
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0042613Cellular componentMHC class II protein complex
GO_0031905Cellular componentearly endosome lumen
GO_0030670Cellular componentphagocytic vesicle membrane
GO_0042612Cellular componentMHC class I protein complex
GO_0012507Cellular componentER to Golgi transport vesicle membrane
GO_1990712Cellular componentHFE-transferrin receptor complex
GO_0005765Cellular componentlysosomal membrane
GO_0042803Molecular functionprotein homodimerization activity
GO_0042802Molecular functionidentical protein binding
GO_0005198Molecular functionstructural molecule activity
GO_0023026Molecular functionMHC class II protein complex binding
GO_0005515Molecular functionprotein binding
GO_0042605Molecular functionpeptide antigen binding

IV. Literature review

[source]
Gene nameB2M
Protein nameBeta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]
Human nkt tcr alpha chain (Human nkt tcr beta chain)
Beta 2-microglobulin protein (Beta-2-microglobulin)
Human nkt tcr beta chain
Beta-2-microglobulin
Synonymsbeta
hCG_1786707
CDABP0092
2-microglobulin
HDCMA22P
DescriptionFUNCTION: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation . .

AccessionsENST00000559916.1
ENST00000631575.1
ENST00000557901.5
Q16446
F5H6I0
P61769
H0YLF3
ENST00000631573.1
ENST00000632867.1
ENST00000561139.2
ENST00000631728.1
ENST00000648006.3
ENST00000561424.5
ENST00000349264.10
K7N5M4
J3KNU0
ENST00000633158.1
K7N5M3
ENST00000617605.4
ENST00000619603.1