HFE-transferrin receptor complex

I. Involved cell-cell interactions

[source]
Interactors
Protein name
Directionality
Classification
1BMPR1B+BMPR2-BMPR1A - BMR1A_HUMANReceptor-ReceptorSignaling by BMP
2HFE-TFRCHFE_HUMAN - TFR1_HUMANLigand-Receptor
3TF-TFR2TRFE_HUMAN - TFR2_HUMANLigand-ReceptorSignaling by Transferrin
4TF-TFRCTRFE_HUMAN - TFR1_HUMANLigand-ReceptorSignaling by Transferrin

II. Literature review

[source]
NameHFE-transferrin receptor complex
IDGO_1990712
collection_id

Cellular component

Description

A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription.

External URL
Genes