BMPR1A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
astrocyte	19 studies	48% ± 20%	Explore
microglial cell	12 studies	31% ± 12%	Explore
oligodendrocyte precursor cell	11 studies	38% ± 18%	Explore
fibroblast	11 studies	32% ± 13%	Explore
smooth muscle cell	11 studies	31% ± 10%	Explore
adipocyte	10 studies	40% ± 12%	Explore
mast cell	10 studies	35% ± 14%	Explore
oligodendrocyte	10 studies	27% ± 11%	Explore
glutamatergic neuron	9 studies	41% ± 26%	Explore
GABAergic neuron	8 studies	47% ± 19%	Explore
endothelial cell	8 studies	33% ± 15%	Explore
pericyte	8 studies	34% ± 14%	Explore
epithelial cell	7 studies	34% ± 13%	Explore
interneuron	6 studies	47% ± 21%	Explore
neuron	5 studies	45% ± 21%	Explore
cardiac muscle cell	5 studies	48% ± 14%	Explore
basal cell	5 studies	26% ± 15%	Explore
type I pneumocyte	5 studies	45% ± 9%	Explore
type II pneumocyte	5 studies	26% ± 7%	Explore
granule cell	4 studies	29% ± 8%	Explore
macrophage	4 studies	37% ± 9%	Explore
Mueller cell	4 studies	31% ± 7%	Explore
amacrine cell	4 studies	24% ± 6%	Explore
retina horizontal cell	4 studies	22% ± 6%	Explore
retinal cone cell	4 studies	40% ± 10%	Explore
retinal rod cell	4 studies	42% ± 6%	Explore
connective tissue cell	4 studies	27% ± 5%	Explore
ciliated cell	4 studies	29% ± 14%	Explore
club cell	4 studies	32% ± 10%	Explore
goblet cell	4 studies	30% ± 20%	Explore
GABAergic interneuron	3 studies	31% ± 6%	Explore
glial cell	3 studies	28% ± 11%	Explore
progenitor cell	3 studies	38% ± 2%	Explore
myofibroblast cell	3 studies	34% ± 14%	Explore
GABAergic amacrine cell	3 studies	24% ± 6%	Explore
glycinergic amacrine cell	3 studies	24% ± 5%	Explore
hepatocyte	3 studies	29% ± 11%	Explore
ependymal cell	3 studies	50% ± 20%	Explore
chondrocyte	3 studies	26% ± 7%	Explore
respiratory goblet cell	3 studies	26% ± 12%	Explore
transit amplifying cell	3 studies	35% ± 25%	Explore
mesothelial cell	3 studies	34% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	14 studies	37% ± 17%	Explore
eye	5 studies	38% ± 13%	Explore
heart	4 studies	32% ± 9%	Explore
lung	4 studies	21% ± 5%	Explore
adipose	3 studies	32% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3308.62	1445 / 1445	100%	14.17	183 / 183
prostate	100%	3301.53	245 / 245	100%	17.21	500 / 502
ovary	100%	3168.28	180 / 180	99%	13.90	425 / 430
breast	100%	2533.71	459 / 459	99%	13.67	1103 / 1118
lung	99%	1937.37	574 / 578	99%	10.39	1144 / 1155
stomach	100%	2670.69	358 / 359	98%	11.42	280 / 286
brain	98%	1236.39	2586 / 2642	100%	16.24	703 / 705
intestine	100%	4597.18	966 / 966	98%	9.34	514 / 527
bladder	100%	3514.57	21 / 21	97%	9.03	491 / 504
uterus	100%	3793.01	170 / 170	97%	11.11	444 / 459
thymus	100%	3911.35	653 / 653	97%	17.35	585 / 605
adrenal gland	99%	1609.53	255 / 258	96%	8.69	221 / 230
kidney	99%	1172.53	88 / 89	93%	8.28	840 / 901
pancreas	93%	896.53	305 / 328	99%	9.15	176 / 178
skin	100%	2160.48	1806 / 1809	90%	9.71	424 / 472
liver	77%	561.66	173 / 226	64%	3.90	259 / 406
blood vessel	100%	5199.32	1335 / 1335	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	5.79	1 / 1
adipose	100%	2408.12	1203 / 1204	0%	0	0 / 0
muscle	98%	1394.04	786 / 803	0%	0	0 / 0
heart	95%	1797.09	814 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	91%	6.97	41 / 45
spleen	88%	780.49	211 / 241	0%	0	0 / 0
eye	0%	0	0 / 0	66%	4.40	53 / 80
lymph node	0%	0	0 / 0	52%	2.57	15 / 29
peripheral blood	18%	262.95	170 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0030324	Biological process	lung development
GO_0014912	Biological process	negative regulation of smooth muscle cell migration
GO_2000772	Biological process	regulation of cellular senescence
GO_0002062	Biological process	chondrocyte differentiation
GO_0042733	Biological process	embryonic digit morphogenesis
GO_1905292	Biological process	regulation of neural crest cell differentiation
GO_0003203	Biological process	endocardial cushion morphogenesis
GO_0030509	Biological process	BMP signaling pathway
GO_0006955	Biological process	immune response
GO_0002053	Biological process	positive regulation of mesenchymal cell proliferation
GO_0060021	Biological process	roof of mouth development
GO_0001707	Biological process	mesoderm formation
GO_1902895	Biological process	positive regulation of miRNA transcription
GO_0048589	Biological process	developmental growth
GO_0006468	Biological process	protein phosphorylation
GO_1904707	Biological process	positive regulation of vascular associated smooth muscle cell proliferation
GO_0007398	Biological process	ectoderm development
GO_1904414	Biological process	positive regulation of cardiac ventricle development
GO_0042475	Biological process	odontogenesis of dentin-containing tooth
GO_0050673	Biological process	epithelial cell proliferation
GO_0001525	Biological process	angiogenesis
GO_0003161	Biological process	cardiac conduction system development
GO_0003151	Biological process	outflow tract morphogenesis
GO_0071773	Biological process	cellular response to BMP stimulus
GO_0001701	Biological process	in utero embryonic development
GO_0010629	Biological process	negative regulation of gene expression
GO_0060928	Biological process	atrioventricular node cell development
GO_0003183	Biological process	mitral valve morphogenesis
GO_0001649	Biological process	osteoblast differentiation
GO_0010628	Biological process	positive regulation of gene expression
GO_0060391	Biological process	positive regulation of SMAD protein signal transduction
GO_0003223	Biological process	ventricular compact myocardium morphogenesis
GO_0045669	Biological process	positive regulation of osteoblast differentiation
GO_0048352	Biological process	paraxial mesoderm structural organization
GO_0050679	Biological process	positive regulation of epithelial cell proliferation
GO_0001880	Biological process	Mullerian duct regression
GO_0060412	Biological process	ventricular septum morphogenesis
GO_0003215	Biological process	cardiac right ventricle morphogenesis
GO_0048568	Biological process	embryonic organ development
GO_0003148	Biological process	outflow tract septum morphogenesis
GO_0048368	Biological process	lateral mesoderm development
GO_0060045	Biological process	positive regulation of cardiac muscle cell proliferation
GO_0021953	Biological process	central nervous system neuron differentiation
GO_0071363	Biological process	cellular response to growth factor stimulus
GO_0009950	Biological process	dorsal/ventral axis specification
GO_0048382	Biological process	mesendoderm development
GO_0035912	Biological process	dorsal aorta morphogenesis
GO_0001756	Biological process	somitogenesis
GO_0032915	Biological process	positive regulation of transforming growth factor beta2 production
GO_0003186	Biological process	tricuspid valve morphogenesis
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0035019	Biological process	somatic stem cell population maintenance
GO_0048378	Biological process	regulation of lateral mesodermal cell fate specification
GO_0060914	Biological process	heart formation
GO_0003272	Biological process	endocardial cushion formation
GO_1905285	Biological process	fibrous ring of heart morphogenesis
GO_0051148	Biological process	negative regulation of muscle cell differentiation
GO_0010665	Biological process	regulation of cardiac muscle cell apoptotic process
GO_0014032	Biological process	neural crest cell development
GO_0009953	Biological process	dorsal/ventral pattern formation
GO_0021998	Biological process	neural plate mediolateral regionalization
GO_0035137	Biological process	hindlimb morphogenesis
GO_0060043	Biological process	regulation of cardiac muscle cell proliferation
GO_0021983	Biological process	pituitary gland development
GO_0061626	Biological process	pharyngeal arch artery morphogenesis
GO_0003222	Biological process	ventricular trabecula myocardium morphogenesis
GO_0007179	Biological process	transforming growth factor beta receptor signaling pathway
GO_0030501	Biological process	positive regulation of bone mineralization
GO_0050768	Biological process	negative regulation of neurogenesis
GO_0003171	Biological process	atrioventricular valve development
GO_0043025	Cellular component	neuronal cell body
GO_0030425	Cellular component	dendrite
GO_0009897	Cellular component	external side of plasma membrane
GO_0043235	Cellular component	receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_1990712	Cellular component	HFE-transferrin receptor complex
GO_0005901	Cellular component	caveola
GO_0005524	Molecular function	ATP binding
GO_0098821	Molecular function	BMP receptor activity
GO_0004675	Molecular function	transmembrane receptor protein serine/threonine kinase activity
GO_0046872	Molecular function	metal ion binding
GO_0046332	Molecular function	SMAD binding
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0036122	Molecular function	BMP binding
GO_0005025	Molecular function	transforming growth factor beta receptor activity, type I
GO_0005515	Molecular function	protein binding
GO_0042803	Molecular function	protein homodimerization activity

Gene name	BMPR1A
Protein name	Bone morphogenetic protein receptor type 1A Bone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292) receptor protein serine/threonine kinase (EC 2.7.11.30)
Synonyms	ALK3 ACVRLK3
Description	FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. May promote the expression of HAMP, potentially via its interaction with BMP2 (By similarity). .
Accessions	ENST00000480152.3 ENST00000480152.2 ENST00000638429.1 ENST00000372037.8 ENST00000636056.2 P36894 A0A087X0P8 B5BUG9 ENST00000635816.2

BMPR1A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review