TFRC | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	33 studies	32% ± 13%	Explore
myeloid cell	12 studies	34% ± 13%	Explore
monocyte	11 studies	29% ± 11%	Explore
non-classical monocyte	10 studies	29% ± 8%	Explore
classical monocyte	10 studies	23% ± 5%	Explore
endothelial cell	9 studies	41% ± 14%	Explore
dendritic cell	9 studies	23% ± 4%	Explore
astrocyte	9 studies	24% ± 7%	Explore
alveolar macrophage	8 studies	63% ± 5%	Explore
erythrocyte	8 studies	63% ± 17%	Explore
epithelial cell	7 studies	36% ± 13%	Explore
conventional dendritic cell	6 studies	26% ± 11%	Explore
regulatory T cell	6 studies	20% ± 6%	Explore
mononuclear phagocyte	5 studies	25% ± 5%	Explore
retinal ganglion cell	5 studies	39% ± 28%	Explore
erythroblast	5 studies	60% ± 26%	Explore
plasmacytoid dendritic cell	5 studies	29% ± 14%	Explore
basal cell	5 studies	30% ± 15%	Explore
transit amplifying cell	4 studies	36% ± 18%	Explore
microglial cell	4 studies	17% ± 1%	Explore
retinal cone cell	4 studies	24% ± 5%	Explore
abnormal cell	4 studies	20% ± 3%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	49% ± 24%	Explore
B cell	3 studies	18% ± 3%	Explore
T cell	3 studies	31% ± 14%	Explore
hematopoietic precursor cell	3 studies	53% ± 15%	Explore
placental villous trophoblast	3 studies	49% ± 22%	Explore
mesothelial cell	3 studies	22% ± 1%	Explore
tissue-resident macrophage	3 studies	33% ± 10%	Explore
ciliated cell	3 studies	25% ± 8%	Explore
GABAergic neuron	3 studies	38% ± 2%	Explore
glutamatergic neuron	3 studies	44% ± 5%	Explore
goblet cell	3 studies	17% ± 1%	Explore
leukocyte	3 studies	21% ± 2%	Explore
fibroblast	3 studies	24% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	7 studies	20% ± 6%	Explore
liver	5 studies	37% ± 22%	Explore
brain	5 studies	30% ± 8%	Explore
bone marrow	4 studies	25% ± 8%	Explore
peripheral blood	3 studies	18% ± 3%	Explore
placenta	3 studies	32% ± 9%	Explore
eye	3 studies	21% ± 5%	Explore
intestine	3 studies	19% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	3864.24	21 / 21	95%	130.46	481 / 504
lung	99%	13730.53	574 / 578	95%	205.42	1096 / 1155
esophagus	95%	5589.55	1374 / 1445	99%	192.59	181 / 183
uterus	97%	4140.78	165 / 170	94%	134.81	433 / 459
intestine	94%	6821.66	912 / 966	97%	163.71	510 / 527
ovary	100%	21899.70	180 / 180	89%	67.33	382 / 430
breast	99%	4047.29	454 / 459	89%	78.89	996 / 1118
stomach	91%	3836.77	328 / 359	96%	133.81	275 / 286
skin	100%	10637.55	1802 / 1809	85%	71.19	399 / 472
pancreas	83%	2028.92	273 / 328	88%	49.65	156 / 178
brain	94%	3501.87	2481 / 2642	66%	35.44	467 / 705
liver	93%	3416.19	211 / 226	62%	28.97	250 / 406
kidney	97%	3486.15	86 / 89	54%	28.49	491 / 901
thymus	92%	3159.98	604 / 653	39%	12.74	236 / 605
adrenal gland	99%	6065.23	256 / 258	31%	16.90	71 / 230
prostate	92%	3292.28	225 / 245	22%	6.95	111 / 502
spleen	100%	3724.87	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	182.00	45 / 45
adipose	99%	7299.13	1188 / 1204	0%	0	0 / 0
blood vessel	97%	5390.06	1292 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	208.21	28 / 29
heart	86%	4917.92	743 / 861	0%	0	0 / 0
muscle	79%	4410.63	633 / 803	0%	0	0 / 0
peripheral blood	70%	12610.03	653 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	15%	4.30	12 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007584	Biological process	response to nutrient
GO_0042102	Biological process	positive regulation of T cell proliferation
GO_0010039	Biological process	response to iron ion
GO_0031623	Biological process	receptor internalization
GO_0071466	Biological process	cellular response to xenobiotic stimulus
GO_0006953	Biological process	acute-phase response
GO_0010042	Biological process	response to manganese ion
GO_0001558	Biological process	regulation of cell growth
GO_0030316	Biological process	osteoclast differentiation
GO_0045830	Biological process	positive regulation of isotype switching
GO_0150104	Biological process	transport across blood-brain barrier
GO_0033138	Biological process	positive regulation of peptidyl-serine phosphorylation
GO_0010628	Biological process	positive regulation of gene expression
GO_1990830	Biological process	cellular response to leukemia inhibitory factor
GO_0001934	Biological process	positive regulation of protein phosphorylation
GO_0006826	Biological process	iron ion transport
GO_0031334	Biological process	positive regulation of protein-containing complex assembly
GO_0051092	Biological process	positive regulation of NF-kappaB transcription factor activity
GO_0046718	Biological process	symbiont entry into host cell
GO_0035556	Biological process	intracellular signal transduction
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0006879	Biological process	intracellular iron ion homeostasis
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0001666	Biological process	response to hypoxia
GO_0030890	Biological process	positive regulation of B cell proliferation
GO_0033572	Biological process	transferrin transport
GO_1900182	Biological process	positive regulation of protein localization to nucleus
GO_0010637	Biological process	negative regulation of mitochondrial fusion
GO_0032526	Biological process	response to retinoic acid
GO_0046688	Biological process	response to copper ion
GO_0045780	Biological process	positive regulation of bone resorption
GO_0042127	Biological process	regulation of cell population proliferation
GO_0016323	Cellular component	basolateral plasma membrane
GO_0005615	Cellular component	extracellular space
GO_0009897	Cellular component	external side of plasma membrane
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0016020	Cellular component	membrane
GO_0055037	Cellular component	recycling endosome
GO_0005769	Cellular component	early endosome
GO_0070062	Cellular component	extracellular exosome
GO_0055038	Cellular component	recycling endosome membrane
GO_1903561	Cellular component	extracellular vesicle
GO_0030669	Cellular component	clathrin-coated endocytic vesicle membrane
GO_0072562	Cellular component	blood microparticle
GO_0009986	Cellular component	cell surface
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_1990712	Cellular component	HFE-transferrin receptor complex
GO_0010008	Cellular component	endosome membrane
GO_0005905	Cellular component	clathrin-coated pit
GO_0005768	Cellular component	endosome
GO_0042470	Cellular component	melanosome
GO_0004998	Molecular function	transferrin receptor activity
GO_0042803	Molecular function	protein homodimerization activity
GO_0044877	Molecular function	protein-containing complex binding
GO_0019901	Molecular function	protein kinase binding
GO_0042802	Molecular function	identical protein binding
GO_0001618	Molecular function	virus receptor activity
GO_0030544	Molecular function	Hsp70 protein binding
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding
GO_0003725	Molecular function	double-stranded RNA binding

IV. Literature review

[source]

Gene name	TFRC
Protein name	Transferrin receptor Transferrin receptor protein 1 Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)]
Synonyms	hCG_22086
Description	FUNCTION: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes . Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake . Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway . When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion . When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 . .; FUNCTION: (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. . FUNCTION: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway. . FUNCTION: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway. . FUNCTION: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway. . FUNCTION: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway. . FUNCTION: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway. . FUNCTION: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway. . FUNCTION: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway. .
Accessions	G3V0E5 ENST00000698283.1 ENST00000698282.1 F8WBE5 ENST00000698291.1 ENST00000698288.1 ENST00000421258.1 ENST00000698285.1 ENST00000698294.1 P02786 A0A8V8TM41 ENST00000698274.1 ENST00000698286.1 ENST00000392396.7 A0A8V8TLK4 A0A8V8TLK7 A0A8V8TLN0 ENST00000360110.9 ENST00000698290.1 ENST00000420415.5 A0A8V8TND0 A0A8V8TM46 ENST00000698295.1 ENST00000698280.1 A0A8V8TLM6 ENST00000698281.1 A0A8V8TN37

TFRC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review