I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| hepatocyte | 5 studies | 68% ± 12% | |
| erythrocyte | 5 studies | 43% ± 13% | |
| glutamatergic neuron | 3 studies | 20% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| hepatocyte | 5 studies | 68% ± 12% | |
| erythrocyte | 5 studies | 43% ± 13% | |
| glutamatergic neuron | 3 studies | 20% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| liver | 5 studies | 38% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 47139.27 | 226 / 226 | 98% | 358.23 | 398 / 406 |
| brain | 92% | 535.68 | 2438 / 2642 | 75% | 3.26 | 530 / 705 |
| stomach | 75% | 951.50 | 271 / 359 | 77% | 4.31 | 219 / 286 |
| skin | 81% | 125.59 | 1467 / 1809 | 53% | 2.05 | 248 / 472 |
| adrenal gland | 88% | 130.43 | 226 / 258 | 38% | 2.26 | 87 / 230 |
| lung | 49% | 45.47 | 284 / 578 | 74% | 3.20 | 857 / 1155 |
| esophagus | 36% | 33.97 | 516 / 1445 | 84% | 5.67 | 154 / 183 |
| intestine | 35% | 42.60 | 337 / 966 | 83% | 4.18 | 439 / 527 |
| bladder | 38% | 33.86 | 8 / 21 | 77% | 3.28 | 387 / 504 |
| spleen | 100% | 319.94 | 241 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 97% | 436.15 | 903 / 929 | 0% | 0 | 0 / 0 |
| pancreas | 28% | 21.98 | 92 / 328 | 56% | 1.99 | 100 / 178 |
| uterus | 4% | 3.41 | 7 / 170 | 77% | 4.67 | 353 / 459 |
| breast | 15% | 14.88 | 71 / 459 | 63% | 2.59 | 705 / 1118 |
| lymph node | 0% | 0 | 0 / 0 | 76% | 1.91 | 22 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 76% | 3.36 | 34 / 45 |
| ovary | 6% | 6.06 | 10 / 180 | 67% | 2.45 | 287 / 430 |
| kidney | 9% | 8.07 | 8 / 89 | 29% | 1.45 | 261 / 901 |
| thymus | 26% | 24.05 | 172 / 653 | 6% | 0.09 | 34 / 605 |
| adipose | 25% | 28.04 | 306 / 1204 | 0% | 0 | 0 / 0 |
| prostate | 16% | 12.90 | 40 / 245 | 2% | 0.03 | 9 / 502 |
| heart | 15% | 14.39 | 128 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 12% | 10.98 | 165 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 9% | 0.15 | 7 / 80 |
| muscle | 0% | 0.40 | 4 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0010039 | Biological process | response to iron ion |
| GO_0006953 | Biological process | acute-phase response |
| GO_0006898 | Biological process | receptor-mediated endocytosis |
| GO_0140298 | Biological process | endocytic iron import into cell |
| GO_0045807 | Biological process | positive regulation of endocytosis |
| GO_0060586 | Biological process | multicellular organismal-level iron ion homeostasis |
| GO_0099072 | Biological process | regulation of postsynaptic membrane neurotransmitter receptor levels |
| GO_0006826 | Biological process | iron ion transport |
| GO_0090277 | Biological process | positive regulation of peptide hormone secretion |
| GO_1903319 | Biological process | positive regulation of protein maturation |
| GO_0006879 | Biological process | intracellular iron ion homeostasis |
| GO_0071281 | Biological process | cellular response to iron ion |
| GO_0033572 | Biological process | transferrin transport |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0031410 | Cellular component | cytoplasmic vesicle |
| GO_0098794 | Cellular component | postsynapse |
| GO_1990712 | Cellular component | HFE-transferrin receptor complex |
| GO_0004998 | Molecular function | transferrin receptor activity |
| GO_0039706 | Molecular function | co-receptor binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | TFR2 |
| Protein name | Transferrin receptor protein 2 (TfR2) Transferrin receptor 2 TFR2 protein |
| Synonyms | |
| Description | FUNCTION: Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. |
| Accessions | ENST00000431692.5 E7ET36 H7C544 ENST00000462107.1 [Q9UP52-1] A7E248 ENST00000490084.5 ENST00000223051.8 [Q9UP52-1] Q9UP52 |
