TF report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042327Biological processpositive regulation of phosphorylation
GO_0030316Biological processosteoclast differentiation
GO_0034756Biological processregulation of iron ion transport
GO_0019731Biological processantibacterial humoral response
GO_2000147Biological processpositive regulation of cell motility
GO_0006826Biological processiron ion transport
GO_0048260Biological processpositive regulation of receptor-mediated endocytosis
GO_0070371Biological processERK1 and ERK2 cascade
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006879Biological processintracellular iron ion homeostasis
GO_0007015Biological processactin filament organization
GO_0071281Biological processcellular response to iron ion
GO_0045780Biological processpositive regulation of bone resorption
GO_0031647Biological processregulation of protein stability
GO_0045178Cellular componentbasal part of cell
GO_0016324Cellular componentapical plasma membrane
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0030139Cellular componentendocytic vesicle
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0055037Cellular componentrecycling endosome
GO_0005769Cellular componentearly endosome
GO_0070062Cellular componentextracellular exosome
GO_0030669Cellular componentclathrin-coated endocytic vesicle membrane
GO_0009925Cellular componentbasal plasma membrane
GO_0034774Cellular componentsecretory granule lumen
GO_0072562Cellular componentblood microparticle
GO_0009986Cellular componentcell surface
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005770Cellular componentlate endosome
GO_1990712Cellular componentHFE-transferrin receptor complex
GO_0010008Cellular componentendosome membrane
GO_0005905Cellular componentclathrin-coated pit
GO_0031982Cellular componentvesicle
GO_1990459Molecular functiontransferrin receptor binding
GO_0034986Molecular functioniron chaperone activity
GO_0008198Molecular functionferrous iron binding
GO_0008199Molecular functionferric iron binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTF
Protein nameTransferrin
Serotransferrin (Beta-1 metal-binding globulin) (Siderophilin)
TF protein
Serotransferrin (Transferrin) (Beta-1 metal-binding globulin) (Siderophilin)
Transferrin, isoform CRA_c (cDNA FLJ54029, highly similar to Serotransferrin)
SynonymsPRO1400
hCG_2023558
DescriptionFUNCTION: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.; FUNCTION: (Microbial infection) Serves as an iron source for Neisseria species, which capture the protein and extract its iron for their own use. .; FUNCTION: (Microbial infection) Serves as an iron source for parasite T.brucei (strain 427), which capture TF via its own transferrin receptor ESAG6:ESAG7 and extract its iron for its own use. .

FUNCTION: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. .

AccessionsENST00000482271.5
F8WEK9
H7C5E8
ENST00000414694.5
A0PJA6
C9JB55
C9JVG0
F8WC57
ENST00000494430.5
ENST00000461695.1
Q06AH7
B4DHZ6
ENST00000485977.1
F8WCI6
ENST00000466911.5
P02787
ENST00000402696.9