HFE | OmnibusX

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HFE at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	99%	500.16	88 / 89	99%	13.49	890 / 901
esophagus	100%	606.28	1442 / 1445	98%	7.36	179 / 183
lung	99%	565.86	571 / 578	99%	11.16	1138 / 1155
liver	100%	678.77	226 / 226	97%	11.90	394 / 406
intestine	100%	742.81	966 / 966	97%	7.26	511 / 527
breast	100%	758.76	458 / 459	97%	12.00	1081 / 1118
pancreas	99%	450.77	326 / 328	96%	8.41	171 / 178
bladder	100%	768.24	21 / 21	94%	9.55	476 / 504
stomach	99%	590.11	357 / 359	95%	6.54	271 / 286
thymus	100%	758.68	651 / 653	94%	10.18	571 / 605
uterus	100%	668.91	170 / 170	89%	6.93	410 / 459
prostate	100%	784.96	244 / 245	84%	4.75	420 / 502
ovary	99%	702.07	179 / 180	75%	3.23	324 / 430
skin	97%	805.87	1760 / 1809	74%	8.21	348 / 472
adrenal gland	100%	1359.12	258 / 258	60%	4.60	137 / 230
brain	60%	117.94	1581 / 2642	51%	3.39	358 / 705
spleen	100%	1118.56	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	4.21	1 / 1
adipose	100%	741.55	1200 / 1204	0%	0	0 / 0
blood vessel	99%	673.65	1327 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	7.53	43 / 45
heart	93%	360.43	805 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	69%	3.04	20 / 29
peripheral blood	62%	180.76	574 / 929	0%	0	0 / 0
muscle	48%	85.28	389 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	34%	2.00	27 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0002474	Biological process	antigen processing and presentation of peptide antigen via MHC class I
GO_0042446	Biological process	hormone biosynthetic process
GO_0010039	Biological process	response to iron ion
GO_0032435	Biological process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_2000059	Biological process	negative regulation of ubiquitin-dependent protein catabolic process
GO_0002725	Biological process	negative regulation of T cell cytokine production
GO_1900122	Biological process	positive regulation of receptor binding
GO_2000272	Biological process	negative regulation of signaling receptor activity
GO_0034756	Biological process	regulation of iron ion transport
GO_0002476	Biological process	antigen processing and presentation of endogenous peptide antigen via MHC class Ib
GO_0002486	Biological process	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
GO_2000273	Biological process	positive regulation of signaling receptor activity
GO_0032092	Biological process	positive regulation of protein binding
GO_0010628	Biological process	positive regulation of gene expression
GO_2000008	Biological process	regulation of protein localization to cell surface
GO_0060391	Biological process	positive regulation of SMAD protein signal transduction
GO_0060586	Biological process	multicellular organismal-level iron ion homeostasis
GO_0006826	Biological process	iron ion transport
GO_0090277	Biological process	positive regulation of peptide hormone secretion
GO_0065003	Biological process	protein-containing complex assembly
GO_0001916	Biological process	positive regulation of T cell mediated cytotoxicity
GO_1990641	Biological process	response to iron ion starvation
GO_0048260	Biological process	positive regulation of receptor-mediated endocytosis
GO_0030509	Biological process	BMP signaling pathway
GO_0006879	Biological process	intracellular iron ion homeostasis
GO_1904434	Biological process	positive regulation of ferrous iron binding
GO_0071281	Biological process	cellular response to iron ion
GO_1904437	Biological process	positive regulation of transferrin receptor binding
GO_1904283	Biological process	negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I
GO_0019882	Biological process	antigen processing and presentation
GO_1900121	Biological process	negative regulation of receptor binding
GO_2001186	Biological process	negative regulation of CD8-positive, alpha-beta T cell activation
GO_0045178	Cellular component	basal part of cell
GO_0005615	Cellular component	extracellular space
GO_0009897	Cellular component	external side of plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0055037	Cellular component	recycling endosome
GO_0005769	Cellular component	early endosome
GO_0005654	Cellular component	nucleoplasm
GO_0042612	Cellular component	MHC class I protein complex
GO_1990712	Cellular component	HFE-transferrin receptor complex
GO_0045177	Cellular component	apical part of cell
GO_0039706	Molecular function	co-receptor binding
GO_1990459	Molecular function	transferrin receptor binding
GO_0005102	Molecular function	signaling receptor binding
GO_0030881	Molecular function	beta-2-microglobulin binding
GO_0005515	Molecular function	protein binding
GO_0042605	Molecular function	peptide antigen binding

IV. Literature review

[source]

Gene name	HFE
Protein name	Hereditary hemochromatosis protein Hemochromatosis protein E1_2A_B016 Hemochromatosis splice variant 399-2283del,intron6ins Hemochromatosis protein E1_1D_B014 (Hemochromatosis protein E2_1D_B015) Hemochromatosis protein E1_2B_B018 (Hemochromatosis protein E2_2B_B019) Hemochromatosis splice variant 495-2314del HFE HFE protein (Homeostatic iron regulator) HFE protein (Hemochromatosis) (Hemochromatosis protein E1_1B_B012) (Hemochromatosis protein E2A_B011) (Hemochromatosis protein E2_1B_B013) Hemochromatosis protein E1_4A_B022 (Hemochromatosis protein E2_4A_B023) (Hereditary hemochromatosis protein) Hemochromatosis Hemochromatosis protein E1_3B_B020 (Hemochromatosis protein E2_3A_B038) Hemochromatosis splice variant 620-1530del MHC class I-like protein HFE Hemochromatosis splice variant 388-2283del,intron6ins Hemochromatosis protein E1_4B_B024 (Hemochromatosis protein E2_4B_B025) Hemochromatosis protein E2_2A_B017 Homeostatic iron regulator Hemochromatosis splice variant 861-2305del HFE (Hemochromatosis protein E1_6A_B028) (Hemochromatosis protein E1_6C_B030) (Hemochromatosis protein E2_6C_B031) Hemochromatosis protein E1_4C_B026 Hemochromatosis protein Hemochromatosis protein E2_6E_B035 Hereditary hemochromatosis protein (HLA-H) Hereditary haemochromatosis protein (Hereditary hemochromatosis protein) Hemochromatosis splice variant 838-2283del Hemochromatosis protein E2_C12_B037 Hereditary hemochromatosis protein HLA-H Hemochromatosis splice variant delE3,intron3ins,intron4ins Hemochromatosis protein E2_4C_B027
Synonyms	HLAH
Description	FUNCTION: Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. . FUNCTION: Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. . FUNCTION: Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. . FUNCTION: Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. . FUNCTION: Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. . FUNCTION: Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. . FUNCTION: Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. . FUNCTION: Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. . FUNCTION: Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. .
Accessions	ENST00000317896.11 [Q30201-7] Q9TQ79 I1VA71 I1VA56 A0A097CKB2 ENST00000397022.7 [Q30201-5] ENST00000357618.10 [Q30201-1] A0A097CK82 H2E8T5 I1VA57 Q86WL1 Q9HC69 G3LGQ6 H2E8T8 G3LGR1 ENST00000470149.5 Q9BXI5 ENST00000352392.8 [Q30201-11] F8W7W8 Q9HC72 H2E8T4 H7C4K4 H2EQK2 I1VA66 G3LGQ4 G3LGQ7 I1VA70 Q9HC71 ENST00000485729.2 K0I859 Q9HC65 I1VA54 Q30201 ENST00000349999.8 [Q30201-2] Q8MH46 Q9UK37 ENST00000336625.12 [Q30201-10] Q9HC66 ENST00000353147.9 [Q30201-6] J9QF30 A0A097CK74 I1VA72 G3LGQ9 A0A097CK88 Q6B0J5 G3LGR0 H2E8T7 I1VA55 A0A097CK87 F5B2M9 G3LGQ5 K0IIP4 Q9HC63 ENST00000461397.5 [Q30201-3] ENST00000488199.5 [Q30201-4] I1VA65 A0A097CKA4 I1VA63 Q9HC67 ENST00000309234.10

HFE report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review