EZH2 | OmnibusX

Name	Number of supported studies	Average coverage
interneuron	5 studies	25% ± 4%	Explore
epithelial cell	5 studies	25% ± 8%	Explore
CD8-positive, alpha-beta T cell	5 studies	22% ± 5%	Explore
B cell	4 studies	20% ± 3%	Explore
CD4-positive, alpha-beta T cell	4 studies	24% ± 6%	Explore
pro-B cell	4 studies	28% ± 7%	Explore
natural killer cell	4 studies	24% ± 6%	Explore
plasmablast	3 studies	39% ± 9%	Explore
hematopoietic precursor cell	3 studies	27% ± 7%	Explore
oligodendrocyte precursor cell	3 studies	20% ± 2%	Explore
plasma cell	3 studies	30% ± 9%	Explore
glutamatergic neuron	3 studies	23% ± 7%	Explore
neural progenitor cell	3 studies	33% ± 2%	Explore
transit amplifying cell	3 studies	48% ± 23%	Explore
GABAergic neuron	3 studies	26% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	3 studies	25% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	99%	498.74	178 / 180	97%	20.93	417 / 430
breast	98%	446.88	450 / 459	98%	22.13	1093 / 1118
skin	100%	1739.47	1809 / 1809	95%	21.96	448 / 472
lung	99%	721.98	574 / 578	94%	21.95	1089 / 1155
uterus	89%	393.33	152 / 170	99%	42.13	455 / 459
pancreas	99%	523.27	326 / 328	88%	10.83	157 / 178
stomach	84%	478.21	303 / 359	98%	23.49	279 / 286
bladder	81%	251.05	17 / 21	97%	25.22	489 / 504
intestine	72%	696.84	700 / 966	98%	25.58	515 / 527
esophagus	60%	783.73	874 / 1445	100%	23.26	183 / 183
liver	88%	360.65	200 / 226	61%	7.81	247 / 406
prostate	90%	360.80	221 / 245	52%	4.22	261 / 502
kidney	74%	287.64	66 / 89	48%	4.07	433 / 901
adrenal gland	95%	358.26	244 / 258	27%	2.87	61 / 230
brain	32%	170.89	854 / 2642	85%	18.84	600 / 705
thymus	75%	230.43	491 / 653	36%	9.89	215 / 605
lymph node	0%	0	0 / 0	100%	49.91	29 / 29
spleen	100%	1178.98	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	41.88	45 / 45
ureter	0%	0	0 / 0	100%	8.75	1 / 1
adipose	96%	378.19	1154 / 1204	0%	0	0 / 0
muscle	85%	305.67	679 / 803	0%	0	0 / 0
peripheral blood	78%	1530.29	721 / 929	0%	0	0 / 0
blood vessel	42%	118.67	561 / 1335	0%	0	0 / 0
heart	42%	111.03	361 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	26%	1.82	21 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006325	Biological process	chromatin organization
GO_0045814	Biological process	negative regulation of gene expression, epigenetic
GO_0030216	Biological process	keratinocyte differentiation
GO_0032355	Biological process	response to estradiol
GO_0070314	Biological process	G1 to G0 transition
GO_0021766	Biological process	hippocampus development
GO_1902808	Biological process	positive regulation of cell cycle G1/S phase transition
GO_0032259	Biological process	methylation
GO_0043547	Biological process	positive regulation of GTPase activity
GO_0014898	Biological process	cardiac muscle hypertrophy in response to stress
GO_0021695	Biological process	cerebellar cortex development
GO_0031048	Biological process	regulatory ncRNA-mediated heterochromatin formation
GO_1900016	Biological process	negative regulation of cytokine production involved in inflammatory response
GO_0034244	Biological process	negative regulation of transcription elongation by RNA polymerase II
GO_1904772	Biological process	response to tetrachloromethane
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0048387	Biological process	negative regulation of retinoic acid receptor signaling pathway
GO_0042752	Biological process	regulation of circadian rhythm
GO_0031507	Biological process	heterochromatin formation
GO_0035984	Biological process	cellular response to trichostatin A
GO_0043406	Biological process	positive regulation of MAP kinase activity
GO_0045617	Biological process	negative regulation of keratinocyte differentiation
GO_0070301	Biological process	cellular response to hydrogen peroxide
GO_0031509	Biological process	subtelomeric heterochromatin formation
GO_0097421	Biological process	liver regeneration
GO_0030335	Biological process	positive regulation of cell migration
GO_1900006	Biological process	positive regulation of dendrite development
GO_0036211	Biological process	protein modification process
GO_0036333	Biological process	hepatocyte homeostasis
GO_0140718	Biological process	facultative heterochromatin formation
GO_0090183	Biological process	regulation of kidney development
GO_0051154	Biological process	negative regulation of striated muscle cell differentiation
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_2000737	Biological process	negative regulation of stem cell differentiation
GO_0014013	Biological process	regulation of gliogenesis
GO_0071168	Biological process	protein localization to chromatin
GO_0010718	Biological process	positive regulation of epithelial to mesenchymal transition
GO_2000134	Biological process	negative regulation of G1/S transition of mitotic cell cycle
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0051932	Biological process	synaptic transmission, GABAergic
GO_0048863	Biological process	stem cell differentiation
GO_0048511	Biological process	rhythmic process
GO_0071902	Biological process	positive regulation of protein serine/threonine kinase activity
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0030183	Biological process	B cell differentiation
GO_0014834	Biological process	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
GO_0000082	Biological process	G1/S transition of mitotic cell cycle
GO_0045120	Cellular component	pronucleus
GO_0005654	Cellular component	nucleoplasm
GO_0005677	Cellular component	chromatin silencing complex
GO_0035098	Cellular component	ESC/E(Z) complex
GO_0045202	Cellular component	synapse
GO_0005721	Cellular component	pericentric heterochromatin
GO_0005694	Cellular component	chromosome
GO_0000781	Cellular component	chromosome, telomeric region
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_1990841	Molecular function	promoter-specific chromatin binding
GO_0003682	Molecular function	chromatin binding
GO_0043021	Molecular function	ribonucleoprotein complex binding
GO_0003714	Molecular function	transcription corepressor activity
GO_0001222	Molecular function	transcription corepressor binding
GO_0046976	Molecular function	histone H3K27 methyltransferase activity
GO_0140951	Molecular function	histone H3K27 trimethyltransferase activity
GO_0042054	Molecular function	histone methyltransferase activity
GO_0106222	Molecular function	lncRNA binding
GO_0016279	Molecular function	protein-lysine N-methyltransferase activity
GO_0031490	Molecular function	chromatin DNA binding
GO_0140938	Molecular function	histone H3 methyltransferase activity
GO_0070878	Molecular function	primary miRNA binding
GO_0005515	Molecular function	protein binding
GO_0000979	Molecular function	RNA polymerase II core promoter sequence-specific DNA binding

IV. Literature review

[source]

Gene name	EZH2
Protein name	Enhancer of zeste 2 polycomb repressive complex 2 subunit Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) [histone H3]-lysine(27) N-trimethyltransferase (EC 2.1.1.356) Alternative protein EZH2 Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6) EZH2 protein Enhancer of zeste 2 polycomb repressive complex 2 subunit (Enhancer of zeste homolog 2 (Drosophila), isoform CRA_b)
Synonyms	KMT6 hCG_15497 tcag7.507
Description	FUNCTION: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 . Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription. .
Accessions	A0A090N8E9 A0A804HJH1 A0A804HLB8 ENST00000476773.5 [Q15910-5] Q6R125 F2YMM1 ENST00000483012.1 E9PDH6 ENST00000350995.6 [Q15910-3] Q15910 ENST00000683744.1 L0R855 ENST00000684300.1 ENST00000682317.1 G3XAL2 ENST00000320356.7 [Q15910-2] ENST00000478654.5 [Q15910-5] Q75MP9 S4S3R8 ENST00000492143.5 ENST00000460911.5 [Q15910-1] Q75MQ0 ENST00000483967.5 [Q15910-4] ENST00000683292.1

EZH2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review