GNAQ report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009649Biological processentrainment of circadian clock
GO_0006469Biological processnegative regulation of protein kinase activity
GO_0007213Biological processG protein-coupled acetylcholine receptor signaling pathway
GO_0010543Biological processregulation of platelet activation
GO_0060158Biological processphospholipase C-activating dopamine receptor signaling pathway
GO_0007596Biological processblood coagulation
GO_0007603Biological processphototransduction, visible light
GO_0050821Biological processprotein stabilization
GO_0007189Biological processadenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0001508Biological processaction potential
GO_0007215Biological processglutamate receptor signaling pathway
GO_0060828Biological processregulation of canonical Wnt signaling pathway
GO_0005886Cellular componentplasma membrane
GO_0001750Cellular componentphotoreceptor outer segment
GO_0070062Cellular componentextracellular exosome
GO_0005794Cellular componentGolgi apparatus
GO_0045202Cellular componentsynapse
GO_0005737Cellular componentcytoplasm
GO_0005834Cellular componentheterotrimeric G-protein complex
GO_0031965Cellular componentnuclear membrane
GO_0005765Cellular componentlysosomal membrane
GO_0031683Molecular functionG-protein beta/gamma-subunit complex binding
GO_0005096Molecular functionGTPase activator activity
GO_0001664Molecular functionG protein-coupled receptor binding
GO_0005525Molecular functionGTP binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameGNAQ
Protein nameGuanine nucleotide binding protein
Guanine nucleotide-binding protein G(q) subunit alpha (Guanine nucleotide-binding protein alpha-q)
G protein subunit alpha q
SynonymsGAQ
DescriptionFUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Required for platelet activation. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) . Together with GNA11, required for heart development (By similarity). .

AccessionsP50148
B1AM21
ENST00000286548.9
ENST00000411677.1
G9FP35
G9FP37
G9FP38