FLRT2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2001222Biological processregulation of neuron migration
GO_0061343Biological processcell adhesion involved in heart morphogenesis
GO_0008150Biological processbiological_process
GO_0050919Biological processnegative chemotaxis
GO_0071711Biological processbasement membrane organization
GO_0051965Biological processpositive regulation of synapse assembly
GO_0003007Biological processheart morphogenesis
GO_0007411Biological processaxon guidance
GO_0008543Biological processfibroblast growth factor receptor signaling pathway
GO_0005615Cellular componentextracellular space
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0070062Cellular componentextracellular exosome
GO_0031012Cellular componentextracellular matrix
GO_0043005Cellular componentneuron projection
GO_0005925Cellular componentfocal adhesion
GO_0005911Cellular componentcell-cell junction
GO_0045202Cellular componentsynapse
GO_0005104Molecular functionfibroblast growth factor receptor binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0045499Molecular functionchemorepellent activity

IV. Literature review

[source]
Gene nameFLRT2
Protein nameLeucine-rich repeat transmembrane protein FLRT2 (Fibronectin-like domain-containing leucine-rich transmembrane protein 2)
Fibronectin leucine rich transmembrane protein 2
SynonymsUNQ232/PRO265
KIAA0405
DescriptionFUNCTION: Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis. .

AccessionsENST00000682132.1
ENST00000330753.6
ENST00000554746.1
ENST00000683129.1
ENST00000684303.1
A0A804HKH2
O43155