EIF6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000377Biological processregulation of reactive oxygen species metabolic process
GO_0000054Biological processribosomal subunit export from nucleus
GO_1902626Biological processassembly of large subunit precursor of preribosome
GO_0035278Biological processmiRNA-mediated gene silencing by inhibition of translation
GO_0032868Biological processresponse to insulin
GO_0045652Biological processregulation of megakaryocyte differentiation
GO_0006413Biological processtranslational initiation
GO_0006110Biological processregulation of glycolytic process
GO_0042304Biological processregulation of fatty acid biosynthetic process
GO_0035195Biological processmiRNA-mediated post-transcriptional gene silencing
GO_0045727Biological processpositive regulation of translation
GO_0042256Biological processcytosolic ribosome assembly
GO_0000460Biological processmaturation of 5.8S rRNA
GO_0000470Biological processmaturation of LSU-rRNA
GO_0005730Cellular componentnucleolus
GO_0005638Cellular componentlamin filament
GO_0030687Cellular componentpreribosome, large subunit precursor
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003743Molecular functiontranslation initiation factor activity
GO_0043022Molecular functionribosome binding
GO_0043023Molecular functionribosomal large subunit binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEIF6
Protein nameEukaryotic translation initiation factor 6 (eIF-6) (B(2)GCN homolog) (B4 integrin interactor) (CAB) (p27(BBP))
Eukaryotic translation initiation factor 6
SynonymsOK/SW-cl.27
EIF3A
ITGB4BP
DescriptionFUNCTION: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm . Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity . In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (By similarity). Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC . Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth (By similarity). .

AccessionsP56537
ENST00000456600.1
ENST00000440766.5
ENST00000415116.1
ENST00000374450.8 [P56537-1]
F8WDS6
ENST00000374443.7 [P56537-2]
B7ZBH1
ENST00000447927.6
F8WD20
A0A0B4J1Y7
ENST00000374436.7 [P56537-1]
ENST00000675032.1 [P56537-1]