MAGI2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0010976Biological processpositive regulation of neuron projection development
GO_0003402Biological processplanar cell polarity pathway involved in axis elongation
GO_0007165Biological processsignal transduction
GO_0038180Biological processnerve growth factor signaling pathway
GO_0032926Biological processnegative regulation of activin receptor signaling pathway
GO_0002092Biological processpositive regulation of receptor internalization
GO_0043113Biological processreceptor clustering
GO_0051898Biological processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0060395Biological processSMAD protein signal transduction
GO_1990090Biological processcellular response to nerve growth factor stimulus
GO_0072015Biological processpodocyte development
GO_0030336Biological processnegative regulation of cell migration
GO_0072583Biological processclathrin-dependent endocytosis
GO_0032516Biological processpositive regulation of phosphoprotein phosphatase activity
GO_0007399Biological processnervous system development
GO_0036057Cellular componentslit diaphragm
GO_0005886Cellular componentplasma membrane
GO_0001750Cellular componentphotoreceptor outer segment
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005813Cellular componentcentrosome
GO_0032991Cellular componentprotein-containing complex
GO_0001917Cellular componentphotoreceptor inner segment
GO_0030425Cellular componentdendrite
GO_0005814Cellular componentcentriole
GO_0005911Cellular componentcell-cell junction
GO_0045202Cellular componentsynapse
GO_0014069Cellular componentpostsynaptic density
GO_0005770Cellular componentlate endosome
GO_0005737Cellular componentcytoplasm
GO_0097546Cellular componentciliary base
GO_0005923Cellular componentbicellular tight junction
GO_0005634Cellular componentnucleus
GO_0070699Molecular functiontype II activin receptor binding
GO_0046332Molecular functionSMAD binding
GO_0019902Molecular functionphosphatase binding
GO_0031697Molecular functionbeta-1 adrenergic receptor binding
GO_0030159Molecular functionsignaling receptor complex adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMAGI2
Protein nameMembrane associated guanylate kinase, WW and PDZ domain containing 2
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Atrophin-1-interacting protein 1) (AIP-1) (Atrophin-1-interacting protein A) (Membrane-associated guanylate kinase inverted 2) (MAGI-2)
SynonymshCG_40263
AIP1
KIAA0705
ACVRINP1
DescriptionFUNCTION: Seems to act as a scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins (By similarity). Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth (By similarity). May play a role in regulating activin-mediated signaling in neuronal cells (By similarity). Enhances the ability of PTEN to suppress AKT1 activation . Plays a role in receptor-mediated clathrin-dependent endocytosis which is required for ciliogenesis (By similarity). .

AccessionsENST00000628361.1
A0A0D9SGF8
A0A0D9SF86
A0A0D9SFY9
ENST00000419488.5 [Q86UL8-2]
ENST00000519748.5
A0A1B0GVS6
ENST00000524268.1
ENST00000522342.3
ENST00000637585.1
ENST00000637282.1
A0A1B0GVS0
ENST00000522391.3
A0A0D9SEY4
ENST00000636178.1
A0A1B0GUF0
ENST00000636717.1
ENST00000637441.1
ENST00000629359.2
A0A0D9SFP3
A0A0U1RRH4
ENST00000634996.1
Q86UL8
A0A1B0GTH8
A0A1B0GUI9
A0A0D9SGF2
A0A0D9SET0
E7EWI0
ENST00000630991.2
ENST00000628781.1
A0A1B0GTC0
ENST00000637486.1
ENST00000354212.9 [Q86UL8-1]
ENST00000636039.1
ENST00000626691.2
A0A0D9SEZ7
A0A1B0GUV4