I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| retinal bipolar neuron | 4 studies | 22% ± 4% | |
| glutamatergic neuron | 4 studies | 28% ± 12% | |
| GABAergic neuron | 3 studies | 28% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| retinal bipolar neuron | 4 studies | 22% ± 4% | |
| glutamatergic neuron | 4 studies | 28% ± 12% | |
| GABAergic neuron | 3 studies | 28% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 3 studies | 27% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 96% | 2012.33 | 2534 / 2642 | 84% | 5.57 | 592 / 705 |
| prostate | 89% | 465.40 | 217 / 245 | 65% | 2.17 | 327 / 502 |
| ovary | 99% | 1931.22 | 179 / 180 | 26% | 1.00 | 110 / 430 |
| uterus | 96% | 1461.99 | 163 / 170 | 21% | 2.43 | 97 / 459 |
| ureter | 0% | 0 | 0 / 0 | 100% | 1.09 | 1 / 1 |
| skin | 79% | 258.37 | 1424 / 1809 | 3% | 0.16 | 16 / 472 |
| breast | 68% | 405.00 | 310 / 459 | 14% | 0.32 | 159 / 1118 |
| thymus | 42% | 89.57 | 274 / 653 | 12% | 0.53 | 74 / 605 |
| adipose | 54% | 284.21 | 647 / 1204 | 0% | 0 | 0 / 0 |
| heart | 51% | 486.87 | 437 / 861 | 0% | 0 | 0 / 0 |
| lung | 37% | 96.15 | 211 / 578 | 6% | 0.19 | 68 / 1155 |
| intestine | 37% | 91.41 | 357 / 966 | 1% | 0.08 | 7 / 527 |
| adrenal gland | 9% | 24.09 | 24 / 258 | 20% | 1.13 | 47 / 230 |
| stomach | 21% | 59.99 | 75 / 359 | 2% | 0.16 | 7 / 286 |
| esophagus | 19% | 39.13 | 272 / 1445 | 2% | 0.06 | 3 / 183 |
| blood vessel | 14% | 32.42 | 190 / 1335 | 0% | 0 | 0 / 0 |
| bladder | 10% | 22.71 | 2 / 21 | 3% | 0.17 | 17 / 504 |
| pancreas | 1% | 0.91 | 2 / 328 | 7% | 0.16 | 12 / 178 |
| eye | 0% | 0 | 0 / 0 | 3% | 0.27 | 2 / 80 |
| tonsil | 0% | 0 | 0 / 0 | 2% | 0.03 | 1 / 45 |
| kidney | 1% | 1.30 | 1 / 89 | 1% | 0.22 | 9 / 901 |
| spleen | 1% | 2.21 | 3 / 241 | 0% | 0 | 0 / 0 |
| liver | 0% | 0 | 0 / 226 | 1% | 0.02 | 4 / 406 |
| peripheral blood | 1% | 1.56 | 8 / 929 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0.43 | 2 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0086015 | Biological process | SA node cell action potential |
| GO_0042391 | Biological process | regulation of membrane potential |
| GO_0086027 | Biological process | AV node cell to bundle of His cell signaling |
| GO_0086002 | Biological process | cardiac muscle cell action potential involved in contraction |
| GO_0086016 | Biological process | AV node cell action potential |
| GO_0098703 | Biological process | calcium ion import across plasma membrane |
| GO_0086046 | Biological process | membrane depolarization during SA node cell action potential |
| GO_0070509 | Biological process | calcium ion import |
| GO_0086018 | Biological process | SA node cell to atrial cardiac muscle cell signaling |
| GO_0007268 | Biological process | chemical synaptic transmission |
| GO_0060371 | Biological process | regulation of atrial cardiac muscle cell membrane depolarization |
| GO_0086045 | Biological process | membrane depolarization during AV node cell action potential |
| GO_0086091 | Biological process | regulation of heart rate by cardiac conduction |
| GO_0003163 | Biological process | sinoatrial node development |
| GO_0010045 | Biological process | response to nickel cation |
| GO_0070588 | Biological process | calcium ion transmembrane transport |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005891 | Cellular component | voltage-gated calcium channel complex |
| GO_0045202 | Cellular component | synapse |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0086059 | Molecular function | voltage-gated calcium channel activity involved SA node cell action potential |
| GO_0086056 | Molecular function | voltage-gated calcium channel activity involved in AV node cell action potential |
| GO_0097110 | Molecular function | scaffold protein binding |
| GO_0008332 | Molecular function | low voltage-gated calcium channel activity |
| GO_0008331 | Molecular function | high voltage-gated calcium channel activity |
| Gene name | CACNA1G |
| Protein name | Voltage-dependent T-type calcium channel subunit alpha-1G (Cav3.1c) (NBR13) (Voltage-gated calcium channel subunit alpha Cav3.1) Voltage-dependent T-type calcium channel alpha 1G subunit isoform B Voltage-dependent T-type calcium channel alpha 1G subunit isoform A Calcium voltage-gated channel subunit alpha1 G |
| Synonyms | KIAA1123 |
| Description | FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. . |
| Accessions | H0YAN0 ENST00000514181.5 [O43497-15] ENST00000515411.5 [O43497-16] ENST00000358244.9 [O43497-5] ENST00000505165.5 [O43497-18] ENST00000352832.9 [O43497-2] ENST00000513689.6 [O43497-25] ENST00000513964.5 [O43497-26] ENST00000570567.1 ENST00000511765.5 [O43497-30] ENST00000442258.6 [O43497-3] A0A0B4J1X2 ENST00000514079.5 [O43497-21] ENST00000507896.5 [O43497-19] ENST00000515765.5 [O43497-7] ENST00000512389.5 [O43497-6] X5D9G8 ENST00000506520.1 ENST00000514717.5 [O43497-22] O43497 ENST00000510366.5 [O43497-23] ENST00000416767.8 ENST00000511768.5 [O43497-28] ENST00000504076.5 [O43497-32] ENST00000510115.5 [O43497-8] ENST00000515165.5 [O43497-11] ENST00000354983.8 [O43497-33] ENST00000502264.5 [O43497-10] ENST00000507336.5 [O43497-20] ENST00000503436.5 [O43497-29] ENST00000506406.5 [O43497-31] ENST00000507609.5 [O43497-17] ENST00000359106.10 [O43497-1] ENST00000503485.5 [O43497-24] X5D9M1 ENST00000429973.6 [O43497-13] ENST00000507510.6 [O43497-12] ENST00000360761.8 [O43497-9] ENST00000503607.5 [O43497-27] I3L2W8 |
