I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 3 studies | 30% ± 12% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 3 studies | 30% ± 12% |
Insufficient scRNA-seq data for expression of CACNB3 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| uterus | 100% | 5062.09 | 170 / 170 | 100% | 17.73 | 457 / 459 |
| ovary | 100% | 5865.17 | 180 / 180 | 99% | 15.68 | 425 / 430 |
| breast | 99% | 1318.20 | 455 / 459 | 100% | 23.82 | 1113 / 1118 |
| bladder | 100% | 1883.38 | 21 / 21 | 99% | 19.89 | 497 / 504 |
| intestine | 100% | 2106.15 | 966 / 966 | 98% | 12.23 | 519 / 527 |
| prostate | 100% | 2006.99 | 245 / 245 | 98% | 9.52 | 493 / 502 |
| lung | 100% | 1700.11 | 577 / 578 | 98% | 14.27 | 1133 / 1155 |
| esophagus | 100% | 2427.86 | 1445 / 1445 | 98% | 11.22 | 179 / 183 |
| thymus | 100% | 1434.26 | 650 / 653 | 98% | 12.79 | 593 / 605 |
| skin | 99% | 1386.82 | 1796 / 1809 | 90% | 8.69 | 427 / 472 |
| brain | 94% | 4212.31 | 2478 / 2642 | 96% | 11.61 | 674 / 705 |
| stomach | 91% | 863.77 | 327 / 359 | 96% | 10.44 | 274 / 286 |
| kidney | 99% | 1259.21 | 88 / 89 | 87% | 9.28 | 783 / 901 |
| adrenal gland | 40% | 242.47 | 103 / 258 | 78% | 15.27 | 179 / 230 |
| pancreas | 19% | 116.26 | 63 / 328 | 97% | 16.45 | 172 / 178 |
| ureter | 0% | 0 | 0 / 0 | 100% | 4.36 | 1 / 1 |
| adipose | 98% | 1264.81 | 1185 / 1204 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 11.49 | 44 / 45 |
| blood vessel | 97% | 1400.88 | 1301 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 95% | 794.47 | 230 / 241 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 89% | 7.00 | 71 / 80 |
| heart | 60% | 383.51 | 515 / 861 | 0% | 0 | 0 / 0 |
| liver | 3% | 15.49 | 6 / 226 | 15% | 1.62 | 59 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 14% | 0.54 | 4 / 29 |
| peripheral blood | 12% | 70.05 | 111 / 929 | 0% | 0 | 0 / 0 |
| muscle | 8% | 45.33 | 62 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0072659 | Biological process | protein localization to plasma membrane |
| GO_0050852 | Biological process | T cell receptor signaling pathway |
| GO_0061577 | Biological process | calcium ion transmembrane transport via high voltage-gated calcium channel |
| GO_1901385 | Biological process | regulation of voltage-gated calcium channel activity |
| GO_0007528 | Biological process | neuromuscular junction development |
| GO_0007268 | Biological process | chemical synaptic transmission |
| GO_1901843 | Biological process | positive regulation of high voltage-gated calcium channel activity |
| GO_0060402 | Biological process | calcium ion transport into cytosol |
| GO_0098903 | Biological process | regulation of membrane repolarization during action potential |
| GO_0006816 | Biological process | calcium ion transport |
| GO_1990454 | Cellular component | L-type voltage-gated calcium channel complex |
| GO_0016020 | Cellular component | membrane |
| GO_0005891 | Cellular component | voltage-gated calcium channel complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0045202 | Cellular component | synapse |
| GO_0005246 | Molecular function | calcium channel regulator activity |
| GO_0005245 | Molecular function | voltage-gated calcium channel activity |
| GO_0008331 | Molecular function | high voltage-gated calcium channel activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | CACNB3 |
| Protein name | Calcium voltage-gated channel auxiliary subunit beta 3 Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3) Voltage-dependent L-type calcium channel subunit beta-3 (Calcium channel voltage-dependent subunit beta 3) |
| Synonyms | CACNLB3 |
| Description | FUNCTION: Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents . Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). . |
| Accessions | ENST00000548874.5 ENST00000540990.5 [P54284-3] F8VNV8 ENST00000550064.5 ENST00000548279.5 ENST00000550391.5 ENST00000547392.5 ENST00000551544.5 F8VWK1 ENST00000301050.7 [P54284-1] F8W1N3 P54284 H0YHK1 ENST00000536187.6 [P54284-4] F8VUW8 H0YHY2 ENST00000547230.5 [P54284-5] ENST00000550190.1 ENST00000547818.5 F8VU10 F8W0F8 ENST00000550483.5 F8VV14 |
