YBX1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051781Biological processpositive regulation of cell division
GO_0010468Biological processregulation of gene expression
GO_2000767Biological processpositive regulation of cytoplasmic translation
GO_0050658Biological processRNA transport
GO_0008544Biological processepidermis development
GO_0006397Biological processmRNA processing
GO_1990428Biological processmiRNA transport
GO_0001701Biological processin utero embryonic development
GO_0098761Biological processcellular response to interleukin-7
GO_1903608Biological processprotein localization to cytoplasmic stress granule
GO_2000773Biological processnegative regulation of cellular senescence
GO_0048255Biological processmRNA stabilization
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0008380Biological processRNA splicing
GO_0048598Biological processembryonic morphogenesis
GO_0070934Biological processCRD-mediated mRNA stabilization
GO_0051154Biological processnegative regulation of striated muscle cell differentiation
GO_0006355Biological processregulation of DNA-templated transcription
GO_1900152Biological processnegative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO_0051031Biological processtRNA transport
GO_0017148Biological processnegative regulation of translation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0005689Cellular componentU12-type spliceosomal complex
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0000932Cellular componentP-body
GO_0071204Cellular componenthistone pre-mRNA 3'end processing complex
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0070937Cellular componentCRD-mediated mRNA stability complex
GO_1990904Cellular componentribonucleoprotein complex
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0003676Molecular functionnucleic acid binding
GO_0003682Molecular functionchromatin binding
GO_0062153Molecular functionC5-methylcytidine-containing RNA reader activity
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0003690Molecular functiondouble-stranded DNA binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0051020Molecular functionGTPase binding
GO_0003729Molecular functionmRNA binding
GO_0003723Molecular functionRNA binding
GO_0035198Molecular functionmiRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameYBX1
Protein nameY-box-binding protein 1 (Y-box transcription factor)
YBX1 protein
Y-box-binding protein 1 (YB-1) (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor)
SynonymsYB1
NSEP1
DescriptionFUNCTION: DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation . Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) . Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay . Component of the CRD-mediated complex that promotes MYC mRNA stability . Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs . Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs . Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs . Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection . Binds to TSC22D1 transcripts, thereby inhibiting their translation and negatively regulating TGF-beta-mediated transcription of COL1A2 (By similarity). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' . Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes . Promotes separation of DNA strands that contain mismatches or are modified by cisplatin . Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair . The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation . .

AccessionsENST00000321358.12
Q6PKI6
ENST00000332220.10
P67809
C9J5V9
A0JLU4
H0Y449
ENST00000436427.1