NDFIP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051224Biological processnegative regulation of protein transport
GO_0032410Biological processnegative regulation of transporter activity
GO_0002761Biological processregulation of myeloid leukocyte differentiation
GO_0010629Biological processnegative regulation of gene expression
GO_0035739Biological processCD4-positive, alpha-beta T cell proliferation
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0030001Biological processmetal ion transport
GO_0002829Biological processnegative regulation of type 2 immune response
GO_0045732Biological processpositive regulation of protein catabolic process
GO_0050728Biological processnegative regulation of inflammatory response
GO_0006879Biological processintracellular iron ion homeostasis
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0032713Biological processnegative regulation of interleukin-4 production
GO_0045619Biological processregulation of lymphocyte differentiation
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0007034Biological processvacuolar transport
GO_0048294Biological processnegative regulation of isotype switching to IgE isotypes
GO_0048302Biological processregulation of isotype switching to IgG isotypes
GO_2000562Biological processnegative regulation of CD4-positive, alpha-beta T cell proliferation
GO_0005576Cellular componentextracellular region
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0030425Cellular componentdendrite
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0045202Cellular componentsynapse
GO_0005938Cellular componentcell cortex
GO_0010008Cellular componentendosome membrane
GO_0050699Molecular functionWW domain binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNDFIP1
Protein nameNEDD4 family-interacting protein 1 (Breast cancer-associated protein SGA-1M) (NEDD4 WW domain-binding protein 5) (Putative MAPK-activating protein PM13) (Putative NF-kappa-B-activating protein 164) (Putative NFKB and MAPK-activating protein)
SynonymsN4WBP5
PSEC0192
PSEC0223
DescriptionFUNCTION: Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cell-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity). Promotes pancreatic beta cell death through degradation of JUNB and inhibition of the unfolded protein response, leading to reduction of insulin secretion . Restricts the production of pro-inflammatory cytokines in effector Th17 T-cells by promoting ITCH-mediated ubiquitination and degradation of RORC (By similarity). Together with NDFIP2, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (By similarity). Regulates peripheral T-cell tolerance to self and foreign antigens, forcing the exit of naive CD4+ T-cells from the cell cycle before they become effector T-cells (By similarity). Negatively regulates RLR-mediated antiviral response by promoting SMURF1-mediated ubiquitination and subsequent degradation of MAVS . Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus where it mediates KCNH2 degradation . In cortical neurons, mediates the ubiquitination of the divalent metal transporter SLC11A2/DMT1 by NEDD4L, leading to its down-regulation and protection of the cells from cobalt and iron toxicity . Important for normal development of dendrites and dendritic spines in cortex (By similarity). Enhances the ubiquitination of BRAT1 mediated by: NEDD4, NEDD4L and ITCH and is required for the nuclear localization of ubiquitinated BRAT1 . Enhances the ITCH-mediated ubiquitination of MAP3K7 by recruiting E2 ubiquitin-conjugating enzyme UBE2L3 to ITCH (By similarity). Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate . Inhibits cell proliferation by promoting PTEN nuclear localization and changing its signaling specificity . .

AccessionsENST00000253814.6 [Q9BT67-1]
Q9BT67