I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| retinal cone cell | 5 studies | 48% ± 23% | |
| neuron | 4 studies | 65% ± 28% | |
| retinal pigment epithelial cell | 3 studies | 34% ± 12% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| retinal cone cell | 5 studies | 48% ± 23% | |
| neuron | 4 studies | 65% ± 28% | |
| retinal pigment epithelial cell | 3 studies | 34% ± 12% |
Insufficient scRNA-seq data for expression of CHRNA3 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| intestine | 100% | 924.75 | 962 / 966 | 32% | 1.16 | 167 / 527 |
| adrenal gland | 55% | 1210.80 | 142 / 258 | 73% | 325.79 | 169 / 230 |
| ureter | 0% | 0 | 0 / 0 | 100% | 3.54 | 1 / 1 |
| stomach | 48% | 426.56 | 172 / 359 | 34% | 2.31 | 98 / 286 |
| pancreas | 13% | 9.62 | 43 / 328 | 57% | 2.95 | 101 / 178 |
| brain | 52% | 182.74 | 1378 / 2642 | 17% | 0.55 | 118 / 705 |
| esophagus | 51% | 142.73 | 732 / 1445 | 17% | 0.35 | 31 / 183 |
| uterus | 38% | 48.43 | 64 / 170 | 26% | 1.72 | 120 / 459 |
| skin | 51% | 63.72 | 922 / 1809 | 10% | 0.38 | 46 / 472 |
| bladder | 38% | 26.90 | 8 / 21 | 22% | 0.83 | 113 / 504 |
| thymus | 41% | 33.03 | 269 / 653 | 13% | 8.36 | 80 / 605 |
| prostate | 36% | 35.98 | 87 / 245 | 10% | 0.29 | 49 / 502 |
| eye | 0% | 0 | 0 / 0 | 30% | 1.62 | 24 / 80 |
| heart | 27% | 30.70 | 233 / 861 | 0% | 0 | 0 / 0 |
| ovary | 10% | 10.84 | 18 / 180 | 10% | 0.27 | 41 / 430 |
| lung | 3% | 2.92 | 15 / 578 | 17% | 0.91 | 191 / 1155 |
| tonsil | 0% | 0 | 0 / 0 | 18% | 0.58 | 8 / 45 |
| breast | 10% | 10.16 | 46 / 459 | 6% | 0.22 | 62 / 1118 |
| spleen | 15% | 8.82 | 36 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 9% | 25.55 | 87 / 929 | 0% | 0 | 0 / 0 |
| muscle | 9% | 5.20 | 71 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 4% | 3.18 | 53 / 1335 | 0% | 0 | 0 / 0 |
| liver | 0% | 0 | 0 / 226 | 3% | 0.19 | 14 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.04 | 1 / 29 |
| adipose | 3% | 2.77 | 39 / 1204 | 0% | 0 | 0 / 0 |
| kidney | 0% | 0 | 0 / 89 | 1% | 0.05 | 10 / 901 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0042391 | Biological process | regulation of membrane potential |
| GO_0051899 | Biological process | membrane depolarization |
| GO_0007171 | Biological process | activation of transmembrane receptor protein tyrosine kinase activity |
| GO_0048814 | Biological process | regulation of dendrite morphogenesis |
| GO_0060079 | Biological process | excitatory postsynaptic potential |
| GO_0007165 | Biological process | signal transduction |
| GO_0034220 | Biological process | monoatomic ion transmembrane transport |
| GO_0006811 | Biological process | monoatomic ion transport |
| GO_0095500 | Biological process | acetylcholine receptor signaling pathway |
| GO_0006940 | Biological process | regulation of smooth muscle contraction |
| GO_0035095 | Biological process | behavioral response to nicotine |
| GO_0060084 | Biological process | synaptic transmission involved in micturition |
| GO_0014056 | Biological process | regulation of acetylcholine secretion, neurotransmission |
| GO_1905144 | Biological process | response to acetylcholine |
| GO_0035094 | Biological process | response to nicotine |
| GO_0007626 | Biological process | locomotory behavior |
| GO_0007399 | Biological process | nervous system development |
| GO_0007271 | Biological process | synaptic transmission, cholinergic |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0016607 | Cellular component | nuclear speck |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0043005 | Cellular component | neuron projection |
| GO_0030425 | Cellular component | dendrite |
| GO_0044853 | Cellular component | plasma membrane raft |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0045202 | Cellular component | synapse |
| GO_0014069 | Cellular component | postsynaptic density |
| GO_0045211 | Cellular component | postsynaptic membrane |
| GO_0005892 | Cellular component | acetylcholine-gated channel complex |
| GO_0015464 | Molecular function | acetylcholine receptor activity |
| GO_0015276 | Molecular function | ligand-gated monoatomic ion channel activity |
| GO_0042166 | Molecular function | acetylcholine binding |
| GO_0022848 | Molecular function | acetylcholine-gated monoatomic cation-selective channel activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | CHRNA3 |
| Protein name | Cholinergic receptor nicotinic alpha 3 subunit Neuronal acetylcholine receptor subunit alpha-3 Neuronal nicotinic acetylcholine receptor, alpha3 subunit |
| Synonyms | NACHRA3 |
| Description | FUNCTION: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. . |
| Accessions | H0YNF9 P32297 Q6EWN2 ENST00000559080.1 ENST00000559658.5 [P32297-2] ENST00000326828.6 [P32297-2] ENST00000348639.7 [P32297-3] |
