RASGRP2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	31 studies	31% ± 13%	Explore
natural killer cell	20 studies	24% ± 6%	Explore
memory B cell	19 studies	31% ± 9%	Explore
non-classical monocyte	19 studies	34% ± 16%	Explore
naive B cell	18 studies	34% ± 8%	Explore
CD4-positive, alpha-beta T cell	18 studies	28% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	29% ± 11%	Explore
CD8-positive, alpha-beta T cell	13 studies	27% ± 7%	Explore
plasmacytoid dendritic cell	12 studies	26% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	30% ± 7%	Explore
classical monocyte	12 studies	27% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	30% ± 11%	Explore
platelet	10 studies	34% ± 9%	Explore
mature NK T cell	10 studies	22% ± 6%	Explore
regulatory T cell	10 studies	27% ± 9%	Explore
pericyte	9 studies	21% ± 5%	Explore
T cell	8 studies	26% ± 6%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	27% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	25% ± 4%	Explore
mucosal invariant T cell	6 studies	20% ± 3%	Explore
smooth muscle cell	6 studies	21% ± 6%	Explore
gamma-delta T cell	6 studies	28% ± 9%	Explore
hematopoietic precursor cell	5 studies	31% ± 9%	Explore
plasmablast	5 studies	41% ± 19%	Explore
monocyte	5 studies	23% ± 6%	Explore
endothelial cell	5 studies	21% ± 5%	Explore
precursor B cell	5 studies	30% ± 11%	Explore
pro-B cell	5 studies	40% ± 7%	Explore
hematopoietic stem cell	4 studies	26% ± 12%	Explore
megakaryocyte	4 studies	41% ± 18%	Explore
immature B cell	4 studies	45% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	35% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	29% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	32% ± 4%	Explore
common myeloid progenitor	3 studies	39% ± 5%	Explore
double negative thymocyte	3 studies	24% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	14 studies	31% ± 12%	Explore
bone marrow	3 studies	27% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	98%	2594.18	239 / 245	96%	4.56	484 / 502
brain	91%	2039.69	2417 / 2642	100%	9.20	704 / 705
lung	100%	3775.05	577 / 578	83%	3.62	954 / 1155
uterus	99%	3262.86	169 / 170	75%	3.03	344 / 459
breast	99%	2090.12	453 / 459	74%	2.88	825 / 1118
kidney	88%	1714.36	78 / 89	85%	4.55	763 / 901
thymus	83%	1401.23	543 / 653	88%	7.79	533 / 605
intestine	98%	4718.55	951 / 966	68%	2.56	359 / 527
bladder	100%	2650.29	21 / 21	65%	2.35	328 / 504
adrenal gland	81%	903.99	208 / 258	75%	2.53	172 / 230
stomach	82%	1489.39	294 / 359	72%	2.54	205 / 286
esophagus	86%	2659.81	1246 / 1445	55%	1.88	101 / 183
liver	40%	364.82	91 / 226	76%	3.19	308 / 406
lymph node	0%	0	0 / 0	100%	42.56	29 / 29
spleen	100%	16572.26	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	1.20	1 / 1
blood vessel	100%	5029.18	1334 / 1335	0%	0	0 / 0
adipose	99%	2740.21	1196 / 1204	0%	0	0 / 0
heart	99%	1709.20	853 / 861	0%	0	0 / 0
pancreas	5%	43.32	18 / 328	90%	7.23	160 / 178
skin	31%	311.27	559 / 1809	64%	4.60	304 / 472
ovary	53%	851.33	96 / 180	40%	0.94	173 / 430
peripheral blood	93%	12060.62	863 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	78%	4.31	35 / 45
muscle	46%	398.47	367 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	20%	0.41	16 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007165	Biological process	signal transduction
GO_0007265	Biological process	Ras protein signal transduction
GO_0001558	Biological process	regulation of cell growth
GO_0043547	Biological process	positive regulation of GTPase activity
GO_0071277	Biological process	cellular response to calcium ion
GO_0032587	Cellular component	ruffle membrane
GO_0005829	Cellular component	cytosol
GO_0045202	Cellular component	synapse
GO_0005886	Cellular component	plasma membrane
GO_0043005	Cellular component	neuron projection
GO_0005085	Molecular function	guanyl-nucleotide exchange factor activity
GO_0019992	Molecular function	diacylglycerol binding
GO_0005509	Molecular function	calcium ion binding
GO_0008289	Molecular function	lipid binding

IV. Literature review

[source]

Gene name	RASGRP2
Protein name	RASGRP2 protein RAS guanyl-releasing protein 2 (Calcium and DAG-regulated guanine nucleotide exchange factor I) (CalDAG-GEFI) (Cdc25-like protein) (hCDC25L) (F25B3.3 kinase-like protein) RAS guanyl releasing protein 2
Synonyms	CDC25L MCG7
Description	FUNCTION: Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. .
Accessions	E7EWQ7 ENST00000394430.5 ENST00000354024.7 [Q7LDG7-1] ENST00000377494.5 [Q7LDG7-4] ENST00000430645.1 ENST00000377487.5 C9JZ82 ENST00000377489.5 ENST00000394428.5 ENST00000441258.5 Q7LDG7 E7EMB4 Q2YDB1 ENST00000377486.7 ENST00000394432.8 [Q7LDG7-1] ENST00000377485.5 A6NJ28 ENST00000445445.5 A8MVK8 C9JKH6 ENST00000419843.1 ENST00000421556.5 A0A4Y6EZ54 ENST00000377497.7 [Q7LDG7-1] A6NHE2 ENST00000431822.5 E7EM78 ENST00000394429.5 A8MTF9

RASGRP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review